Hemoglobin subunit zeta

{{Short description|Mammalian protein found in Homo sapiens}}

{{Infobox_gene}}

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.{{cite journal | vauthors = Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ | title = A review of the molecular genetics of the human alpha-globin gene cluster | journal = Blood | volume = 73 | issue = 5 | pages = 1081–104 | date = April 1989 | pmid = 2649166 | doi = 10.1182/blood.V73.5.1081.1081| doi-access = free }}{{cite web | title = Entrez Gene: HBZ hemoglobin, zeta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3050}}

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.

References

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Further reading

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  • {{cite journal | vauthors = Giardina B, Messana I, Scatena R, Castagnola M | title = The multiple functions of hemoglobin | journal = Critical Reviews in Biochemistry and Molecular Biology | volume = 30 | issue = 3 | pages = 165–96 | year = 1995 | pmid = 7555018 | doi = 10.3109/10409239509085142 }}
  • {{cite journal | vauthors = Proudfoot NJ, Brownlee GG | title = 3' non-coding region sequences in eukaryotic messenger RNA | journal = Nature | volume = 263 | issue = 5574 | pages = 211–4 | date = September 1976 | pmid = 822353 | doi = 10.1038/263211a0 | bibcode = 1976Natur.263..211P | s2cid = 4211839 }}
  • {{cite journal | vauthors = Fougerousse F, Meloni R, Roudaut C, Beckmann JS | title = Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1) | journal = Nucleic Acids Research | volume = 20 | issue = 5 | pages = 1165 | date = March 1992 | pmid = 1549498 | pmc = 312136 | doi = 10.1093/nar/20.5.1165 }}
  • {{cite journal | vauthors = Hess J, Perez-Stable C, Wu GJ, Weir B, Tinoco I, Shen CK | title = End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication | journal = Journal of Molecular Biology | volume = 184 | issue = 1 | pages = 7–21 | date = July 1985 | pmid = 2411938 | doi = 10.1016/0022-2836(85)90039-7 }}
  • {{cite journal | vauthors = Marotta CA, Forget BG, Weissman SM, Verma IM, McCaffrey RP, Baltimore D | title = Nucleotide sequences of human globin messenger RNA | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 71 | issue = 6 | pages = 2300–4 | date = June 1974 | pmid = 4135409 | pmc = 388440 | doi = 10.1073/pnas.71.6.2300 | bibcode = 1974PNAS...71.2300M | doi-access = free }}
  • {{cite journal | vauthors = Perez-Stable C, Ayres TM, Shen CK | title = Distinctive sequence organization and functional programming of an Alu repeat promoter | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 81 | issue = 17 | pages = 5291–5 | date = September 1984 | pmid = 6089189 | pmc = 391689 | doi = 10.1073/pnas.81.17.5291 | bibcode = 1984PNAS...81.5291P | doi-access = free }}
  • {{cite journal | vauthors = Clegg JB, Gagnon J | title = Structure of the zeta chain of human embryonic hemoglobin | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 78 | issue = 10 | pages = 6076–80 | date = October 1981 | pmid = 6171809 | pmc = 348980 | doi = 10.1073/pnas.78.10.6076 | bibcode = 1981PNAS...78.6076C | doi-access = free }}
  • {{cite journal | vauthors = Aschauer H, Schäfer W, Sanguansermsri T, Braunitzer G | title = [Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)] | journal = Hoppe-Seyler's Zeitschrift für Physiologische Chemie | volume = 362 | issue = 12 | pages = 1657–9 | date = December 1981 | pmid = 6172357 }}
  • {{cite journal | vauthors = Aschauer H, Sanguansermsri T, Braunitzer G | title = [Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)] | journal = Hoppe-Seyler's Zeitschrift für Physiologische Chemie | volume = 362 | issue = 8 | pages = 1159–62 | date = August 1981 | pmid = 6179844 }}
  • {{cite journal | vauthors = Proudfoot NJ, Gil A, Maniatis T | title = The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene | journal = Cell | volume = 31 | issue = 3 Pt 2 | pages = 553–63 | date = December 1982 | pmid = 6297773 | doi = 10.1016/0092-8674(82)90311-7 | s2cid = 36907055 }}
  • {{cite journal | vauthors = Goodbourn SE, Higgs DR, Clegg JB, Weatherall DJ | title = Molecular basis of length polymorphism in the human zeta-globin gene complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 80 | issue = 16 | pages = 5022–6 | date = August 1983 | pmid = 6308667 | pmc = 384180 | doi = 10.1073/pnas.80.16.5022 | bibcode = 1983PNAS...80.5022G | doi-access = free }}
  • {{cite journal | vauthors = Cohen-Solal MM, Authier B, deRiel JK, Murnane MJ, Forget BG | title = Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA | journal = DNA | volume = 1 | issue = 4 | pages = 355–63 | year = 1983 | pmid = 6963223 | doi = 10.1089/dna.1982.1.355 }}
  • {{cite journal | vauthors = Orkin SH, Michelson A | title = Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia | journal = Nature | volume = 286 | issue = 5772 | pages = 538–40 | date = July 1980 | pmid = 7402334 | doi = 10.1038/286538a0 | bibcode = 1980Natur.286..538O | s2cid = 4251647 }}
  • {{cite journal | vauthors = Flint J, Thomas K, Micklem G, Raynham H, Clark K, Doggett NA, King A, Higgs DR | title = The relationship between chromosome structure and function at a human telomeric region | journal = Nature Genetics | volume = 15 | issue = 3 | pages = 252–7 | date = March 1997 | pmid = 9054936 | doi = 10.1038/ng0397-252 | s2cid = 20630444 }}
  • {{cite journal | vauthors = Luo HY, Liang XL, Frye C, Wonio M, Hankins GD, Chui DH, Alter BP | title = Embryonic hemoglobins are expressed in definitive cells | journal = Blood | volume = 94 | issue = 1 | pages = 359–61 | date = July 1999 | pmid = 10381533 | doi = 10.1182/blood.V94.1.359.413a29_359_361}}
  • {{cite journal | vauthors = Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR | title = Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 | journal = Human Molecular Genetics | volume = 10 | issue = 4 | pages = 339–52 | date = February 2001 | pmid = 11157797 | doi = 10.1093/hmg/10.4.339 | doi-access = free }}
  • {{cite journal | vauthors = Lau ET, Kwok YK, Chui DH, Wong HS, Luo HY, Tang MH | title = Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures | journal = Prenatal Diagnosis | volume = 21 | issue = 7 | pages = 529–39 | date = July 2001 | pmid = 11494285 | doi = 10.1002/pd.81 | s2cid = 11841129 }}

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{{Hemeproteins}}

Category:Hemoglobins

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