HEPPS (buffer)

{{chembox

| verifiedrevid = 443851591

| Name = HEPPS

| ImageFile = 3-(4-(2-hydroxyethyl)piperazin-1-yl)propane-1-sulfonic acid 200.svg

| ImageSize = 200px

| ImageName = HEPPS

| PIN = 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid

| OtherNames = HEPPS, EPPS

|Section1={{Chembox Identifiers

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 76886

| PubChem = 85255

| InChI = 1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)

| InChIKey = OWXMKDGYPWMGEB-UHFFFAOYAP

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = OWXMKDGYPWMGEB-UHFFFAOYSA-N

| CASNo = 16052-06-5

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 8JN5PQW99C

| ChEBI_Ref = {{ebicite|correct|EBI}}

| ChEBI = 42298

| SMILES = O=S(=O)(O)CCCN1CCN(CCO)CC1

}}

|Section2={{Chembox Properties

| C=9|H=20|N=2|O=4|S=1

| Density =

| MeltingPt = (decomposes)

}}

}}

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.{{Cite journal | pmid = 5942950| year = 1966| last1 = Good| first1 = N. E| title = Hydrogen ion buffers for biological research| journal = Biochemistry| volume = 5| issue = 2| pages = 467–77| last2 = Winget| first2 = G. D| last3 = Winter| first3 = W| last4 = Connolly| first4 = T. N| last5 = Izawa| first5 = S| last6 = Singh| first6 = R. M| doi=10.1021/bi00866a011}}

Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.{{cite magazine|title=Small Molecule Breaks Up Amyloid Aggregates In Mice |url=http://cen.acs.org/articles/93/web/2015/12/Small-Molecule-Breaks-Amyloid-Aggregates.html|magazine = Chemical & Engineering News |access-date=14 December 2015}}{{cite journal|last1=Kim|first1=Hye Yun|last2=Kim|first2=Hyunjin Vincent|last3=Jo|first3=Seonmi|last4=Lee|first4=C. Justin|last5=Choi|first5=Seon Young|last6=Kim|first6=Dong Jin|last7=Kim|first7=YoungSoo|title=EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques|journal=Nature Communications|date=8 December 2015|volume=6|pages=8997|doi=10.1038/ncomms9997|pmid=26646366|pmc=4686862|bibcode=2015NatCo...6.8997K}}{{cite web | url = http://medicalxpress.com/news/2015-12-chemical-alzheimer-protein-memory-mice.html | publisher = MedicalXpress | title = Chemical clears Alzheimer's protein and restores memory in mice | access-date = December 10, 2015}} HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.{{Cite journal|last1=Kim|first1=YoungSoo|last2=Yoo|first2=Yong Kyoung|last3=Kim|first3=Hye Yun|last4=Roh|first4=Jee Hoon|last5=Kim|first5=Jinsik|last6=Baek|first6=Seungyeop|last7=Lee|first7=Jinny Claire|last8=Kim|first8=Hye Jin|last9=Chae|first9=Myung-Sic|last10=Jeong|first10=Dahye|last11=Park|first11=Dongsung|date=2019-04-01|title=Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system|journal=Science Advances|language=en|volume=5|issue=4|pages=eaav1388|doi=10.1126/sciadv.aav1388|pmid=31001580|pmc=6469948|bibcode=2019SciA....5.1388K|issn=2375-2548|doi-access=free}}{{Cite web|url=https://www.technologynetworks.com/analysis/news/blood-test-for-detecting-pre-symptomatic-alzheimers-disease-is-refined-318368|title=Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined|website=Analysis & Separations from Technology Networks|language=en|access-date=2019-09-30}}{{Cite web|url=https://medicalxpress.com/news/2019-04-blood-early-stage-alzheimer-disease.html|title=A possible blood test for early-stage Alzheimer's disease|website=medicalxpress.com|language=en-us|access-date=2019-09-30}}