HLA-DR12

The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215

There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common

on the West Pacific Rim and particularly Indochina and the South Pacific.

DR12 is associated with vulval lichen sclerosus,{{cite journal |vauthors=Gao X, Barnardo M, Winsey S, Ahmad T, Cook J, Agudelo J, Zhai N, Powell J, Fuggle S, Wojnarowska F | title = The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus. | journal = J Invest Dermatol | volume = 125 | issue = 5 | pages = 895–9 | year = 2005 | pmid = 16297186 | doi = 10.1111/j.0022-202X.2005.23905.x| doi-access = free }} and undifferentiated spondyloarthritis.{{cite journal |vauthors=Liao HT, Lin KC, Chen CH, etal | title = Human Leukocyte Antigens in Undifferentiated Spondyloarthritis | journal = Seminars in Arthritis and Rheumatism| volume = 37| issue = 3| pages = 198–201| year = 2007 | pmid = 17604825 | doi = 10.1016/j.semarthrit.2007.04.004}}

DRB1*1201 is associated with iritis in juvenile arthritis,{{cite journal |vauthors=Cerna M, Vavrincova P, Havelka S, Ivaskova E, Stastny P | title = Class II alleles in juvenile arthritis in Czech children. | journal = J Rheumatol | volume = 21 | issue = 1 | pages = 159–64 | year = 1994 | pmid = 8151573}} primary antiphospholipid syndrome,{{cite journal |vauthors=Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D | title = Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients. | journal = Arthritis Rheum | volume = 38 | issue = 9 | pages = 1340–1 | year = 1995 | pmid = 7575732 | doi = 10.1002/art.1780380925| doi-access = }} tiopronin intolerance in rheumatoid arthritis,{{cite journal |vauthors=Ju LY, Paolozzi L, Delecoeuillerie G, etal | title = A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis | journal = Clin. Exp. Rheumatol. | volume = 12 | issue = 3 | pages = 249–54 | year = 1994 | pmid = 7915222 }} adult chronic articular Still's disease{{cite journal |vauthors=Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M, Suwa A, Hirakata M, Mimori T | title = Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease. | journal = Rheumatology (Oxford) | volume = 40 | issue = 12 | pages = 1398–404 | year = 2001 | pmid = 11752512 | doi = 10.1093/rheumatology/40.12.1398| doi-access = free }}

DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population,{{cite journal |vauthors=Himmunngan P, Sangwatanaroj S, Petmitr S, Viroonudomphol D, Siriyong P, Patmasiriwat P | title = HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families) | journal = Southeast Asian J. Trop. Med. Public Health | volume = 37 | issue = 2 | pages = 357–65 | year = 2006 | pmid = 17124999 }} and narcolepsy in the Japanese population.

DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease{{cite journal | doi = 10.1111/j.1399-0039.1992.tb01965.x |vauthors=Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P | title = HLA class II alleles associated with celiac disease susceptibility in a southern European population. | journal = Tissue Antigens | volume = 40 | issue = 2 | pages = 90–7 | year = 1992 | pmid = 1357780}}

DRB1*1201:DRB3*01/03: colorectal cancer{{cite journal |vauthors=Bidwell J, Soong T, Raymond P, Doherty D, Hui K | title = HLA genotyping of colorectal carcinoma in the Chinese population. | journal = Hum Immunol | volume = 34 | issue = 1 | pages = 19–23 | year = 1992 | pmid = 1356954 | doi = 10.1016/0198-8859(92)90080-7}}

HLA-DR12 is genetically linked to DR52{{cite journal |vauthors=Song EY, Park H, Roh EY, Park MH |title=HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004 |pmid=15041167 |doi=10.1016/j.humimm.2003.12.005}} and HLA-DQ7 serotypes.

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{{DR serotypes}}

{{DEFAULTSORT:Hla-Dr12}}

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