HLA-DR52
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| align="center" colspan="3" | Image:DR Illustration.PNG | |
| align="center" colspan="2" | major histocompatibility complex, class II, DR53 | |
| bgcolor="#e7dcc3" | Haplotypes groups
| bgcolor="#eeeeee" | DRA*01:DRB3*01 DRA*01:DRB3*02 DRA*01:DRB3*03 | |
| colspan="2" bgcolor="#dddddd" | Structure (See HLA-DR) | |
| style="background:#f8f8f8"
| bgcolor="#dddddd" | Identifiers | align="center" | alpha *01:01 |
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC4947 HLA-DRA]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRA*0101 DRA*01:01] | |
| style="background:#f8f8f8"
| bgcolor="#dddddd" | Identifiers | align="center" | beta 3 *01 *02 *03 |
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4952 HLA-DRB3]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB3*01 DRB3*01] | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB3*02 DRB3*02] | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB3*03 DRB3*03] {{Webarchive|url=https://web.archive.org/web/20110515163311/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB3*03 |date=2011-05-15 }} | |
| colspan="2" bgcolor="#dddddd" | Shared data | |
| bgcolor="#e7dcc3" | Locus
| bgcolor="#eeeeee" | chr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31] |
HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.
DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution,{{cite journal |vauthors=Gorski J, Rollini P, Mach B |title=Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic |journal=Immunogenetics |volume=25 |issue=6 |pages=397–402 |year=1987 |pmid=3596674 |doi= 10.1007/BF00396106|s2cid=25853147 }} having diverged from DRB1 around 4 million years ago.{{cite journal |vauthors=Gongora R, Figueroa F, Klein J | title = The HLA-DRB9 gene and the origin of HLA-DR haplotypes | journal = Hum. Immunol. | volume = 51 | issue = 1 | pages = 23–31 | year = 1996 | pmid = 8911994 | doi =10.1016/S0198-8859(96)00189-9 | doi-access = free }}
The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
Alleles
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|+ DR52 recognition of some DRB3* alleles[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA] | |||
| style="background:#f0f0ff"
| style="width:60px" | DRB3* | style="width:60px" | DR52
| style="width:60px" | ? | style="width:60px" | Sample | |
| style="background:#f0f0ff"
| allele | % | % | size (N) |
| style = "background:#e8e8f8" | 01:01 | 95 | 62 | |
| style = "background:#e8e8f8" | 01:02 | 99 | 1 | |
| style = "background:#e8e8f8" | 02:01 | 99 | 2 | |
| style = "background:#e8e8f8" | 02:02 | 95 | 100 | |
| style = "background:#e8e8f8" | 02:03 | 95 | 1 | |
| style = "background:#e8e8f8" | 03:01 | 95 | 36 |
Associated diseases
DR52 serotype is positively associated with systemic sclerosis,{{cite journal |vauthors=Kuwana M, Kaburaki J, Okano Y, Inoko H, Tsuji K | title = The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma) | journal = J. Clin. Invest. | volume = 92 | issue = 3 | pages = 1296–301 | year = 1993 | pmid = 7690776 | doi =10.1172/JCI116703 | pmc = 288271 }} inflammatory myopathies,{{cite journal | author = Garlepp MJ | title = Immunogenetics of inflammatory myopathies | journal = Baillière's Clinical Neurology | volume = 2 | issue = 3 | pages = 579–97 | year = 1993 | pmid = 8156144 }} inclusion body myositis,{{cite journal |vauthors=Garlepp MJ, Laing B, Zilko PJ, Ollier W, Mastaglia FL | title = HLA associations with inclusion body myositis | journal = Clin. Exp. Immunol. | volume = 98 | issue = 1 | pages = 40–5 | year = 1994 | pmid = 7923882 | doi = 10.1111/j.1365-2249.1994.tb06604.x| pmc = 1534165 }}
DRB3*01 is positively associated with sarcoidosis,{{cite journal |vauthors=Ishihara M, Ishida T, Mizuki N, Inoko H, Ando H, Ohno S | title = Clinical features of sarcoidosis in relation to HLA distribution and HLA-DRB3 genotyping by PCR-RFLP | journal = The British Journal of Ophthalmology | volume = 79 | issue = 4 | pages = 322–5 | year = 1995 | pmid = 7742275 | doi =10.1136/bjo.79.4.322 | pmc = 505093 }} Grave's Disease,{{cite journal |vauthors=Smikie M, Pascoe R, Barton E, Morgan O, Christian N, Dowe G, Roye-Green K, Bailey V, James O | title = HLA-DRB3*0101 is associated with Graves' disease in Jamaicans | journal = Clin. Endocrinol. | volume = 55 | issue = 6 | pages = 805–8 | year = 2001 | pmid = 11895223 | doi = 10.1046/j.1365-2265.2001.01414.x| s2cid = 27420443 }}{{cite journal |vauthors=Chen Q, Huang W, She J, Baxter F, Volpe R, Maclaren N | title = HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective | journal = J. Clin. Endocrinol. Metab. | volume = 84 | issue = 9 | pages = 3182–6 | year = 1999 | doi = 10.1210/jcem.84.9.5991 | pmid = 10487684 | s2cid = 45571883 | doi-access = free }} pulmonary sarcoidosis,{{cite journal |vauthors=Grunewald J, Berlin M, Olerup O, Eklund A | title = Lung T-helper cells expressing T-cell receptor AV2S3 associate with clinical features of pulmonary sarcoidosis | journal = Am. J. Respir. Crit. Care Med. | volume = 161 | issue = 3 Pt 1 | pages = 814–8 | year = 2000 | pmid = 10712327 | doi=10.1164/ajrccm.161.3.9906001}}
DRB3*01:01:DRB1*03:01 is linked to Lofgren's syndrome{{cite journal |vauthors=Bogunia-Kubik K, Tomeczko J, Suchnicki K, Lange A | title = HLA-DRB1*03, DRB1*11 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis | journal = Tissue Antigens | volume = 57 | issue = 1 | pages = 87–90 | year = 2001 | pmid = 11169267 | doi = 10.1034/j.1399-0039.2001.057001087.x}}
DRB3*02:02 is also linked to Grave's disease, serum IgG antibodies to Chlamydia pneumoniae with essential hypertension,{{cite journal |vauthors=Zabay J, Marco J, Soler J, Contu L, Cappai L, Carcassi C, Gómez G, Mulet J, Munar M, Viader C | title = Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain) | journal = J. Hum. Hypertens. | volume = 19 | issue = 8 | pages = 615–22 | year = 2005 | pmid = 15905891 | doi = 10.1038/sj.jhh.1001872| s2cid = 22045082 | doi-access = }} acute necrotizing encephalopathy{{cite journal |vauthors=Oh H, Kwon S, Kim C, Choe B, Ko C, Jung H, Suh J, Lee J | title = Molecular analysis of HLA class II-associated susceptibility to neuroinflammatory diseases in Korean children | journal = J. Korean Med. Sci. | volume = 19 | issue = 3 | pages = 426–30 | year = 2004 | pmid = 15201511 | doi = 10.3346/jkms.2004.19.3.426 | pmc = 2816846}}
DRB3*03:01 is weakly associated with anticardiolipin antibodies in SLE{{cite journal | author = Galeazzi M | title = HLA class II alleles associations of anticardiolipin and antibeta2GPI antibodies in a large series of European patients with systemic lupus erythematosus | journal = Lupus | volume = 9 | issue = 1 | pages = 47–55 | year = 2000 | pmid = 10715100 | doi = 10.1177/096120330000900109 | author2 = Sebastiani G | author3 = Tincani A | last4 = Piette | first4 = J.-C. | last5 = Allegri | first5 = F. | last6 = Morozzi | first6 = G. | last7 = Bellisai | first7 = F. | last8 = Scorza | first8 = R. | last9 = Ferrara | first9 = G. B.| s2cid = 208624924 }}
DRB3*03:01:DRB1*13:02 may be associated with Crohn's disease{{cite journal | doi = 10.1136/gut.43.2.210 | author = Cariappa A | title = Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease | journal = Gut | volume = 43 | issue = 2 | pages = 210–5 | year = 1998 | pmid = 10189846 | pmc = 1727213 | author2 = Sands B | author3 = Forcione D | last4 = Finkelstein | first4 = D | last5 = Podolsky | first5 = D K | last6 = Pillai | first6 = S}}
=DRB1 linkage=
HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups:
HLA-DR3 - DRB1*03
HLA-DR5 -
HLA-DR6 -
Rarely HLA-DR8 - DRB1*08{{cite journal |last1=Smith |first1=AG |last2=Nelson |first2=JL |last3=Regen |first3=L |last4=Guthrie |first4=LA |last5=Donadi |first5=E |last6=Mickelson |first6=EM |last7=Hansen |first7=JA |title=Six new DR52-associated DRB1 alleles, three of DR8, two of DR11, and one of DR6, reflect a variety of mechanisms which generate polymorphism in the MHC. |journal=Tissue Antigens |date=August 1996 |volume=48 |issue=2 |pages=118–26 |doi=10.1111/j.1399-0039.1996.tb02616.x |pmid=8883301}}
HLA-DR52 - Sjögren syndrome