HLA-DR51
| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="240px" | |
| align="center" colspan="2" | Image:DR Illustration.PNG | |
| align="center" colspan="2" | major histocompatibility complex, class II, DR51 | |
| bgcolor="#e7dcc3" | Haplotypes groups
| bgcolor="#eeeeee" | DRA*01:DRB5*01 DRA*01:DRB5*02 | |
| colspan="2" bgcolor="#dddddd" | Structure (See HLA-DR) | |
| style="background:#f8f8f8"
| bgcolor="#dddddd" | Identifiers | align="center" | alpha *0101 |
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC4947 HLA-DRA]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRA*0101 DRA*0101] | |
| style="background:#f8f8f8"
| bgcolor="#dddddd" | Identifiers | align="center" | beta 5 *01 *02 |
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4953 HLA-DRB5]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB5*01 DRB5*01] | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB5*02 DRB5*02] {{Webarchive|url=https://web.archive.org/web/20110515163737/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB5*02 |date=2011-05-15 }} | |
| colspan="2" bgcolor="#dddddd" | Shared data | |
| bgcolor="#e7dcc3" | Locus
| bgcolor="#eeeeee" | chr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31] |
HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution,{{cite journal |vauthors=Gorski J, Rollini P, Mach B |title=Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic |journal=Immunogenetics |volume=25 |issue=6 |pages=397–402 |year=1987 |pmid=3596674 |doi= 10.1007/BF00396106|s2cid=25853147 }} having diverged from DRB1 approximately 4 million years ago.{{cite journal | vauthors = Gongora R, Figueroa F, Klein J | title = The HLA-DRB9 gene and the origin of HLA-DR haplotypes | journal = Hum. Immunol. | volume = 51 | issue = 1 | pages = 23–31 | year = 1996 | pmid = 8911994 | doi =10.1016/S0198-8859(96)00189-9 | doi-access = free }}
DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5.
Alleles
| border="0" cellspacing="0" cellpadding="0" align="left" style="text-align:center; background:#ffffff; margin-right: 2em; border:2px #e0e0ff solid;"
|+ DR52 recognition of some DRB3* alleles[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA] | |||
| style="background:#f0f0ff"
| style="width:60px" | DRB5* | style="width:60px" | DR51
| style="width:60px" | ? | style="width:60px" | Sample | |
| style="background:#f0f0ff"
| allele | % | % | size (N) |
| style = "background:#e8e8f8" | 0101 | >71 | 28 | |
| style = "background:#e8e8f8" | 0102 | >86 | 8 | |
| style = "background:#e8e8f8" | 0202 | >86 | 13 |
DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.
DRB5*01 allele group
- 14 Alleles: 11 proteins, 2 Nulls
- DR51 Serotype: *0101, *0102
- Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
- Nulls: *0108N, *0110N
DRB5*02 allele group
- 4 Alleles: 4 proteins
- DR51 Serotype: *0202,
- Serotype unknown: *0203 to *0205
Associated diseases
DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:
DRB5*0101:DRB1*1501 Multiple sclerosis,{{cite journal | vauthors = Sospedra M, Muraro P, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R | title = Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype. | journal = J Immunol | volume = 176 | issue = 3 | pages = 1951–61 | year = 2006 | pmid = 16424227 | pmc = 2746197 | doi=10.4049/jimmunol.176.3.1951}} leprosy{{cite journal | vauthors = Joko S, Numaga J, Kawashima H, Namisato M, Maeda H | title = Human leukocyte antigens in forms of leprosy among Japanese patients. | journal = Int J Lepr Other Mycobact Dis | volume = 68 | issue = 1 | pages = 49–56 | year = 2000 | pmid = 10834069}}