HLA-DR16

DR16 is associated with Chaga's cardiomyopathy,{{cite journal |vauthors=Cruz-Robles D, Reyes P, Monteón-Padilla V, Ortiz-Muñiz A, Vargas-Alarcón G | title = MHC class I and class II genes in Mexican patients with Chagas disease. | journal = Hum Immunol | volume = 65 | issue = 1 | pages = 60–5 | year = 2004 | pmid = 14700597 | doi = 10.1016/j.humimm.2003.10.008}} rheumatic heart disease,{{cite journal |vauthors=Hernández-Pacheco G, Aguilar-García J, Flores-Domínguez C, Rodríguez-Pérez J, Pérez-Hernández N, Alvarez-Leon E, Reyes P, Vargas-Alarcón G | title = MHC class II alleles in Mexican patients with rheumatic heart disease. | journal = Int J Cardiol | volume = 92 | issue = 1 | pages = 49–54 | year = 2003 | pmid = 14602216 | doi = 10.1016/S0167-5273(03)00040-8}} coronary artery ectasia,{{cite journal |vauthors=Akdemir R, Ozhan H, Gunduz H, Erbilen E, Yazici M, Duran S, Orkunoglu F, Albayrak S, Imirzalioglu N, Uyan C | title = HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia. | journal = Acta Cardiol | volume = 59 | issue = 5 | pages = 499–502 | year = 2004 | pmid = 15529553 | doi = 10.2143/AC.59.5.2005222| s2cid = 25040717 | hdl = 20.500.12684/6176 | hdl-access = free }} and chronic discoid lupus erythematosus.{{cite journal |vauthors=López-Tello A, Rodríguez-Carreón AA, Jurado F, etal | title = Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients | journal = Clin. Exp. Dermatol. | volume = 32 | issue = 4 | pages = 435–8 | year = 2007 | pmid = 17376212 | doi = 10.1111/j.1365-2230.2007.02391.x| s2cid = 19569740 }}

DRB1*1601 is associated with tuberculosis risk{{cite journal |vauthors=Dubaniewicz A, Moszkowska G, Szczerkowska Z | title = Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report. | journal = Tuberculosis (Edinb) | volume = 85 | issue = 4 | pages = 259–67 | year = 2005 | pmid = 15958261 | doi = 10.1016/j.tube.2004.12.003}}

DRB1*1602: Juvenile rheumatoid arthritis,{{cite journal |vauthors=Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D | title = HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos. | journal = Hum Immunol | volume = 65 | issue = 4 | pages = 359–65 | year = 2004 | pmid = 15120191 | doi = 10.1016/j.humimm.2004.01.016}} rheumatic heart disease, [http://www.takayasus.org/aboutta.htm Takayasu arteritis] {{Webarchive|url=https://web.archive.org/web/20070807054228/http://www.takayasus.org/aboutta.htm |date=2007-08-07 }},{{cite journal |vauthors=Salazar M, Varela A, Ramirez L, Uribe O, Vasquez G, Egea E, Yunis E, Iglesias-Gamarra A | title = Association of HLA-DRB1*1602 and DRB1*1001 with in Colombian mestizos as markers of Amerindian ancestry. | journal = Int J Cardiol | volume = 75 | pages = S113–6 | year = 2000| issue = Suppl 1 | doi = 10.1016/s0167-5273(00)00181-9 | pmid = 10980348}} systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody,{{cite journal |vauthors=Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T | title = Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. | journal = Arthritis Rheum | volume = 42 | issue = 3 | pages = 465–74 | year = 1999 | pmid = 10088769 | doi = 10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y| doi-access = free }}{{cite journal |vauthors=Tan F, Stivers D, Arnett F, Chakraborty R, Howard R, Reveille J | title = HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis). | journal = Tissue Antigens | volume = 53 | issue = 1 | pages = 74–80 | year = 1999 | pmid = 10082433 | doi = 10.1034/j.1399-0039.1999.530108.x| doi-access = free }} melioidosis (Burkholderia pseudomallei infection){{cite journal |vauthors=Dharakul T, Vejbaesya S, Chaowagul W, Luangtrakool P, Stephens H, Songsivilai S | title = HLA-DR and -DQ associations with melioidosis. | journal = Hum Immunol | volume = 59 | issue = 9 | pages = 580–6 | year = 1998 | pmid = 9757914 | doi = 10.1016/S0198-8859(98)00052-4}}

DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk

• *1602:DQA1*0102:DQB1*0502 haplotype: graves disease,{{cite journal |vauthors=Wongsurawat T, Nakkuntod J, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N | title = The association between HLA class II haplotype with Graves' disease in Thai population. | journal = Tissue Antigens | volume = 67 | issue = 1 | pages = 79–83 | year = 2006 | pmid = 16451208 | doi = 10.1111/j.1399-0039.2005.00498.x}}{{cite journal |vauthors=Park M, Park Y, Song E, Park H, Kim T, Park D, Park K, Cho B | title = Association of HLA-DR and -DQ genes with Graves disease in Koreans. | journal = Hum Immunol | volume = 66 | issue = 6 | pages = 741–7 | year = 2005 | pmid = 15993720 | doi = 10.1016/j.humimm.2005.03.001}} cervical cancer (human papilloma virus infection),{{cite journal |vauthors=Cervantes J, Lema C, Valentina Hurtado L, Andrade R, Hurtado Gomez L, Torrico L, Zegarra L, Quiroga G, Asturizaga D, Dulon A, Prada R, Panoso W, Yashiki S, Fujiyoshi T, Sonoda S | title = HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women. | journal = Hum Immunol | volume = 64 | issue = 9 | pages = 890–5 | year = 2003 | pmid = 12941545 | doi = 10.1016/S0198-8859(03)00163-0}} scleroderma
• *1602:DQA1*05:DQB1*0301 haplotype: rheumatic heart disease, systemic sclerosis{{cite journal | vauthors = Arnett F, Howard R, Tan F, Moulds J, Bias W, Durban E, Cameron H, Paxton G, Hodge T, Weathers P, Reveille J | title = Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype. | journal = Arthritis Rheum | volume = 39 | issue = 8 | pages = 1362–70 | year = 1996 | pmid = 8702445 | doi = 10.1002/art.1780390814| doi-access = }}

HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.

{{reflist}}

{{DR serotypes}}

{{DEFAULTSORT:Hla-Dr16}}

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