HLA-DR53

DR53 reactive alleles: DRB4*0101, *0103

Unknown reactivity: *0102, *0104 to *0107

Null alleles: *0101102N, *01030102N, *0201N, *0301N

DRB4*01 is positively associated with Erythema multiforme,{{cite journal |vauthors=Lepage V, Douay C, Mallet C, etal |title=Erythema multiforme is associated to HLA-Aw33 and DRw53 |journal=Tissue Antigens |volume=32 |issue=3 |pages=170–5 |year=1988 |pmid=3217933 |doi= 10.1111/j.1399-0039.1988.tb01654.x}} Crohn's disease,{{cite journal |vauthors=Kobayashi K, Atoh M, Yagita A, etal |title=Crohn's disease in the Japanese is associated with the HLA-DRw53 |journal=Exp. Clin. Immunogenet. |volume=7 |issue=2 |pages=101–8 |year=1990 |pmid=2322470 }} myasthenia gravis,{{cite journal |vauthors=Morita K, Moriuchi J, Inoko H, Tsuji K, Arimori S |title=HLA class II antigens and DNA restriction fragment length polymorphism in myasthenia gravis in Japan |journal=Ann. Neurol. |volume=29 |issue=2 |pages=168–74 |year=1991 |pmid=1672809 |doi=10.1002/ana.410290209|s2cid=45699820 }} rheumatoid arthritis{{cite journal |vauthors=Morling N, Andersen V, Fugger L, etal |title=Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome: DNA polymorphism of HLA class II genes |journal=Dis. Markers |volume=9 |issue=5 |pages=289–96 |year=1991 |pmid=1686751 }} Hashimoto's thyroiditis,{{cite journal |vauthors=Terauchi M, Yanagawa T, Ishikawa N, Ito K, Fukazawa T, Maruyama H, Saruta T | title = Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population. | journal = J Endocrinol Invest | volume = 26 | issue = 12 | pages = 1208–12 | year = 2003 | pmid = 15055474 | doi=10.1007/bf03349159| s2cid = 2344535 }} vitiligo,{{cite journal |vauthors=Zamani M, Spaepen M, Sghar S, Huang C, Westerhof W, Nieuweboer-Krobotova L, Cassiman J | title = Linkage and association of HLA class II genes with vitiligo in a Dutch population. | journal = Br J Dermatol | volume = 145 | issue = 1 | pages = 90–4 | year = 2001 | pmid = 11453913 | doi = 10.1046/j.1365-2133.2001.04288.x| s2cid = 25942367 }} primary biliary cirrhosis,{{cite journal |vauthors=Shimoda S, Nakamura M, Ishibashi H, Hayashida K, Niho Y | title = HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases. | journal = J Exp Med | volume = 181 | issue = 5 | pages = 1835–45 | year = 1995 | pmid = 7536796 | doi = 10.1084/jem.181.5.1835 | pmc = 2191998}} clozapine-induced agranulocytosis,{{cite journal |vauthors=Corzo D, Yunis J, Salazar M, Lieberman J, Howard A, Awdeh Z, Alper C, Yunis E | title = The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups. | journal = Blood | volume = 86 | issue = 10 | pages = 3835–40 | year = 1995 | doi = 10.1182/blood.V86.10.3835.bloodjournal86103835 | pmid = 7579351| doi-access = free }} Vogt–Koyanagi–Harada disease,{{cite journal |vauthors=Kobayashi H, Kokubo T, Takahashi M, Sato K, Miyokawa N, Kimura S, Kinouchi R, Katagiri M | title = Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient. | journal = Immunogenetics | volume = 47 | issue = 5 | pages = 398–403 | year = 1998 | pmid = 9510558 | doi = 10.1007/s002510050375| s2cid = 1592923 }}

HLA-DR53 serotypes (HLA-DRB4) is linked to the following HLADR serotypes (HLA-DRB1) allele groups:

HLA-DR4 - DRB1*04

HLA-DR7 - DRB1*07

HLA-DR9 - DRB1*09

{{reflist}}

{{DR serotypes}}

{{DEFAULTSORT:Hla-Dr53}}

Category:HLA-DR haplotypes