HORMA domain

{{Infobox protein family

| Symbol = HORMA

| Name = HORMA domain

| image = PDB 1go4 EBI.jpg

| width =

| caption = crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20.

| Pfam = PF02301

| Pfam_clan =

| InterPro = IPR003511

| SMART =

| PROSITE =

| MEROPS =

| SCOP = 1duj

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins. Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.{{cite journal|vauthors=He X, Patterson TE, Sazer S | title=The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. | journal=Proc Natl Acad Sci U S A | year= 1997 | volume= 94 | issue= 15 | pages= 7965–70 | pmid=9223296 | doi= 10.1073/pnas.94.15.7965| pmc=21538 | bibcode=1997PNAS...94.7965H | doi-access=free }}{{cite journal|vauthors=Aravind L, Koonin EV | title=The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. | journal=Trends Biochem Sci | year= 1998 | volume= 23 | issue= 8 | pages= 284–6 | pmid=9757827 | doi= 10.1016/S0968-0004(98)01257-2}}