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HOXB7

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.

Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.

Interactions

HOXB7 has been shown to interact with PBX1 and CREB-binding protein.

See also

References

{{reflist|refs=

{{cite web | title = Entrez Gene: HOXB7 homeobox B7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3217}}

{{cite journal | vauthors = Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V | title = CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein | journal = Oncogene | volume = 18 | issue = 27 | pages = 4007–4014 | date = July 1999 | pmid = 10435624 | doi = 10.1038/sj.onc.1202776| doi-access = free }}

{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–553 | date = December 1992 | pmid = 1358459 | doi = 10.1016/0092-8674(92)90588-4| s2cid = 13370372 }}

{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = August 1990 | pmid = 1973146 | doi = 10.1016/0888-7543(90)90186-X}}

{{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes Dev. | volume = 9 | issue = 6 | pages = 663–674 | date = March 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663| doi-access = free }}

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Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Baier LJ, Hannibal MC, Hanley EW, Nabel GJ | title = Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain | journal = Blood | volume = 78 | issue = 4 | pages = 1047–1055 | year = 1991 | pmid = 1678287 | doi = 10.1182/blood.V78.4.1047.1047| doi-access = free }}
  • {{cite journal | vauthors = Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A | title = Expression of HOX homeogenes in human neuroblastoma cell culture lines | journal = Differentiation | volume = 45 | issue = 1 | pages = 61–69 | year = 1990 | pmid = 1981366 | doi = 10.1111/j.1432-0436.1990.tb00458.x }}
  • {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation | volume = 40 | issue = 3 | pages = 191–197 | year = 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x | hdl = 11380/1249645 | hdl-access = free }}
  • {{cite journal | vauthors = Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ | title = Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | issue = 21 | pages = 8536–8540 | year = 1989 | pmid = 2573064 | pmc = 298317 | doi = 10.1073/pnas.86.21.8536 | bibcode = 1989PNAS...86.8536S | doi-access = free }}
  • {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Res. | volume = 17 | issue = 24 | pages = 10385–10402 | year = 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
  • {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–756 | year = 1989 | pmid = 2576652 | doi = 10.1139/g89-133 }}
  • {{cite journal | vauthors = Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E | title = Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 14 | pages = 4914–4918 | year = 1987 | pmid = 2885844 | pmc = 305217 | doi = 10.1073/pnas.84.14.4914 | bibcode = 1987PNAS...84.4914S | doi-access = free }}
  • {{cite journal | vauthors = Lill MC, Fuller JF, Herzig R, Crooks GM, Gasson JC | title = The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation | journal = Blood | volume = 85 | issue = 3 | pages = 692–697 | year = 1995 | pmid = 7530503 | doi = 10.1182/blood.V85.3.692.bloodjournal853692| doi-access = free }}
  • {{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes Dev. | volume = 9 | issue = 6 | pages = 663–674 | year = 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663 | doi-access = free }}
  • {{cite journal | vauthors = Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G | title = Nucleolar localisation of three Hox homeoproteins | journal = J. Cell Sci. | volume = 108 | issue = 1 | pages = 187–193 | year = 1995 | doi = 10.1242/jcs.108.1.187 | pmid = 7738096 | doi-access = free }}
  • {{cite journal | vauthors = Inamori K, Takeshita K, Chiba S, Yazaki Y, Hirai H | title = Identification of homeobox genes expressed in human T-lymphocytes | journal = Biochem. Biophys. Res. Commun. | volume = 196 | issue = 1 | pages = 203–208 | year = 1993 | pmid = 8105782 | doi = 10.1006/bbrc.1993.2235 }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM | title = Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 2 | pages = 900–905 | year = 1996 | pmid = 8570656 | pmc = 40155 | doi = 10.1073/pnas.93.2.900 | bibcode = 1996PNAS...93..900M | doi-access = free }}
  • {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenet. Cell Genet. | volume = 73 | issue = 1–2 | pages = 114–115 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
  • {{cite journal | vauthors = Caré A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C, Colombo MP | title = HOXB7 constitutively activates basic fibroblast growth factor in melanomas | journal = Mol. Cell. Biol. | volume = 16 | issue = 9 | pages = 4842–4851 | year = 1996 | pmid = 8756643 | pmc = 231486 | doi = 10.1128/mcb.16.9.4842}}
  • {{cite journal | vauthors = LeBrun DP, Matthews BP, Feldman BJ, Cleary ML | title = The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains | journal = Oncogene | volume = 15 | issue = 17 | pages = 2059–2067 | year = 1997 | pmid = 9366523 | doi = 10.1038/sj.onc.1201367 | doi-access = free }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison M, Largman C | title = HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development | journal = J. Invest. Dermatol. | volume = 110 | issue = 2 | pages = 110–115 | year = 1998 | pmid = 9457903 | doi = 10.1046/j.1523-1747.1998.00092.x | doi-access = free }}

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External links

  • {{MeshName|HOXB7+protein,+human}}

{{NLM content}}

{{PDB Gallery|geneid=3217}}

{{Transcription factors|g3}}

Category:Transcription factors

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