HSE

• Health and Safety Executive, regulation and enforcement of workplace health, safety and welfare agency in the UK
• Health Service Executive, provision of health and personal social services in the Republic of Ireland
• Health and Safety Executive for Northern Ireland, health body of Northern Ireland
• Holding Slovenske elektrarne, a Slovene power company

• Hamilton Southeastern Schools, the primary school system in Fishers, Indiana, US
• Hamilton Southeastern High School, a public high school
• Helsinki School of Economics, Finland
• National Research University – Higher School of Economics, Moscow, Russia

• Nasdaq Helsinki, formerly the Helsinki Stock Exchange
• Hyderabad Stock Exchange

• Half sphere exposure, a protein solvent exposure measure
• Heyd-Scuseria-Ernzerhof functional, in computational quantum mechanical modelling
• Hydrostatic equilibrium, in fluid mechanics
• Higher Speed Ethernet, in computer networking
• Highly Siderophile element, in planetary geology
• Hybrid search engine, a type of computer search engine

• Health, safety and environment, a discipline focused on regulation and enforcement of workplace health, safety, environmental issues, and welfare in some countries
• Health Survey for England, a statistical survey
• Herpes simplex encephalitis, a viral infection

• Human systems engineering, in systems psychology
• Billy Mitchell Airport, Cape Hatteras, North Carolina, United States, IATA and FAA LID code HSE
• High Specification Equipment, a trim level for Range Rover
• Home Sports Entertainment, a cable sports TV channel that was the forerunner of Fox Sports Southwest
• H.S.E (latin), abbreviation of "Hic Situs Est" (Here is placed)

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