Hanoch Senderowitz

Hanoch Senderowitz received his Ph.D. in 1993 from Tel Aviv University under the supervision of Prof. Benzion Fuchs. He then spent four years as a Post Doctorate Fulbright fellow at Columbia University, working with Prof. W. Clark Still. After returning to Israel in 1997, he joined the pharmaceutical industry, working first at Peptor Ltd. for six years and then at Epix Pharmaceuticals until 2008. In 2009, he joined Bar Ilan University as an associate professor at the Department of Chemistry leading the molecular modeling, computer-aided drug design and chemoinformatics lab.

Senderowitz's research focuses on the developing and application of new computational methods to design compounds (i.e., drugs, materials) with improved properties. This design strategy is multi-disciplinary in nature and consists of various levels of theory, different computational techniques, and different machine learning algorithms. Senderowitz is known for the following areas of research: (1) Research on CFTR (Cystic fibrosis transmembrane conductance regulator), the main protein implicated in the genetic disease Cystic fibrosis, both at the level of the full-length protein{{cite journal|last1=Mei-Zahav|first1=M.|last2=Stafler|first2=P.|last3=Senderowitz|first3=H.|last4=Bentur|first4=L.|last5=Livnat|first5=G.|last6=Shteinberg|first6=M.|last7=Orenstein|first7=N.|last8=Bazak|first8=L.|last9=Prais|first9=D.|last10=Levine|first10=H.|last11=Gur|first11=M.|last12=Khazanov|first12=N.|last13=Simhaev|first13=L.|last14=Eliyahu|first14=H.|last15=Cohen|first15=M.|last16=Wilschanski|first16=M.|last17=Blau|first17=H.|last18=Mussaffi|first18=H.|title=The Q359K/T360K mutation causes cystic fibrosis in Georgian Jews|journal=Journal of Cystic Fibrosis|volume=17|issue=5|year=2018|pages=e41–e45|issn=1569-1993|doi=10.1016/j.jcf.2018.06.008|pmid=30033373|doi-access=free}}{{cite journal|last1=Simhaev|first1=Luba|last2=McCarty|first2=Nael A.|last3=Ford|first3=Robert C.|last4=Senderowitz|first4=Hanoch|title=Molecular Dynamics Flexible Fitting Simulations Identify New Models of the Closed State of the Cystic Fibrosis Transmembrane Conductance Regulator Protein|journal=Journal of Chemical Information and Modeling|volume=57|issue=8|year=2017|pages=1932–1946|issn=1549-9596|doi=10.1021/acs.jcim.7b00091|pmid=28657312|url=https://www.research.manchester.ac.uk/portal/en/publications/molecular-dynamics-flexible-fitting-simulations-identify-new-models-of-the-closed-state-of-the-cystic-fibrosis-transmembrane-conductance-regulator-protein(949abdf2-c2fe-400b-a5b1-0c92cc9ee843).html}}{{cite journal|last1=Thibodeau|first1=Patrick H.|last2=Richardson|first2=John M.|last3=Wang|first3=Wei|last4=Millen|first4=Linda|last5=Watson|first5=Jarod|last6=Mendoza|first6=Juan L.|last7=Du|first7=Kai|last8=Fischman|first8=Sharon|last9=Senderowitz|first9=Hanoch|last10=Lukacs|first10=Gergely L.|last11=Kirk|first11=Kevin|last12=Thomas|first12=Philip J.|title=The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis|journal=Journal of Biological Chemistry|volume=285|issue=46|year=2010|pages=35825–35835|issn=0021-9258|doi=10.1074/jbc.M110.131623|pmid=20667826|pmc=2975206|doi-access=free}} and of its domains.{{cite journal|last1=Chen|first1=Xinying|last2=Zhu|first2=Siyu|last3=Zhenin|first3=Michael|last4=Xu|first4=Weiyi|last5=Bose|first5=Samuel J.|last6=Wong|first6=Molly Pik-Fan|last7=Leung|first7=George P. H.|last8=Senderowitz|first8=Hanoch|last9=Chen|first9=Jeng-Haur|title=A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis–causing mutation|journal=The FASEB Journal|volume=33|issue=4|year=2019|pages=5126–5142|issn=0892-6638|doi=10.1096/fj.201801218RR|pmid=30668920|url=https://research-information.bris.ac.uk/ws/files/183665645/201801218RR_Merged_PDF.pdf|doi-access=free}}{{cite journal|last1=Zhenin|first1=Michael|last2=Noy|first2=Efrat|last3=Senderowitz|first3=Hanoch|title=REMD Simulations Reveal the Dynamic Profile and Mechanism of Action of Deleterious, Rescuing, and Stabilizing Perturbations to NBD1 from CFTR|journal=Journal of Chemical Information and Modeling|volume=55|issue=11|year=2015|pages=2349–2364|issn=1549-9596|doi=10.1021/acs.jcim.5b00312|pmid=26418372}} His basic research focuses on understanding the dynamics of the protein and on the mechanism of action of deleterious, rescuing and stabilizing perturbations to its domains, while his translation research focuses on CFTR as a target for drug discovery. (2) Research on chemoinformatics and materials informatics, focusing on the development of new machine learning algorithms{{cite journal|last1=Kaspi|first1=Omer|last2=Yosipof|first2=Abraham|last3=Senderowitz|first3=Hanoch|title=RANdom SAmple Consensus (RANSAC) algorithm for material-informatics: application to photovoltaic solar cells|journal=Journal of Cheminformatics|volume=9|issue=1|year=2017|page=34|issn=1758-2946|doi=10.1186/s13321-017-0224-0|pmid=29086047|pmc=5461245|doi-access=free}}{{cite journal|last1=Nahum|first1=Oren E.|last2=Yosipof|first2=Abraham|last3=Senderowitz|first3=Hanoch|title=A Multi-Objective Genetic Algorithm for Outlier Removal|journal=Journal of Chemical Information and Modeling|volume=55|issue=12|year=2015|pages=2507–2518|issn=1549-9596|doi=10.1021/acs.jcim.5b00515|pmid=26553402}}{{cite journal|last1=Yosipof|first1=Abraham|last2=Senderowitz|first2=Hanoch|title=k-Nearest neighbors optimization-based outlier removal|journal=Journal of Computational Chemistry|volume=36|issue=8|year=2015|pages=493–506|issn=0192-8651|doi=10.1002/jcc.23803|pmid=25503870|s2cid=7086146}}{{cite journal|last1=Yosipof|first1=Abraham|last2=Senderowitz|first2=Hanoch|title=Optimization of Molecular Representativeness|journal=Journal of Chemical Information and Modeling|volume=54|issue=6|year=2014|pages=1567–1577|issn=1549-9596|doi=10.1021/ci400715n|pmid=24802762}} as well as on their application in various areas, for example, for the analysis and development of solar cells with improved photovoltaic properties.{{cite journal|last1=Kaspi|first1=Omer|last2=Yosipof|first2=Abraham|last3=Senderowitz|first3=Hanoch|title=Visualization of Solar Cell Library Space by Dimensionality Reduction Methods|journal=Journal of Chemical Information and Modeling|volume=58|issue=12|year=2018|pages=2428–2439|issn=1549-9596|doi=10.1021/acs.jcim.8b00552|pmid=30485100|s2cid=54102900}}{{cite journal|last1=Kaspi|first1=Omer|last2=Yosipof|first2=Abraham|last3=Senderowitz|first3=Hanoch|title=PV Analyzer: A Decision Support System for Photovoltaic Solar Cells Libraries|journal=Molecular Informatics|volume=37|issue=9–10|year=2018|pages=1800067|issn=1868-1743|doi=10.1002/minf.201800067|pmid=30022619|s2cid=51696788}}{{cite journal|last1=Yosipof|first1=Abraham|last2=Shimanovich|first2=Klimentiy|last3=Senderowitz|first3=Hanoch|title=Materials Informatics: Statistical Modeling in Material Science|journal=Molecular Informatics|volume=35|issue=11–12|year=2016|pages=568–579|issn=1868-1743|doi=10.1002/minf.201600047|pmid=27870246|s2cid=38316656}}{{cite journal|last1=Yosipof|first1=Abraham|last2=Nahum|first2=Oren E.|last3=Anderson|first3=Assaf Y.|last4=Barad|first4=Hannah-Noa|last5=Zaban|first5=Arie|last6=Senderowitz|first6=Hanoch|title=Data Mining and Machine Learning Tools for Combinatorial Material Science of All-Oxide Photovoltaic Cells|journal=Molecular Informatics|volume=34|issue=6–7|year=2015|pages=367–379|issn=1868-1743|doi=10.1002/minf.201400174|pmid=27490383|s2cid=3985537}} (3) Research on computational agriculture including plant disease biocontrol studying anti-bacterial peptides expressed on virus nanoparticles, design of new pesticides in the form of small molecules that inhibits the bacterial quorum sensing machinery, and the design of new sustainable pesticides in the form of peptide aptamers and small molecules that would interfere with cell building enzymes of bacteria.{{cite journal|last1=Joshi|first1=Janak Raj|last2=Khazanov|first2=Netaly|last3=Senderowitz|first3=Hanoch|last4=Burdman|first4=Saul|last5=Lipsky|first5=Alexander|last6=Yedidia|first6=Iris|title=Plant phenolic volatiles inhibit quorum sensing in pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins|journal=Scientific Reports|volume=6|issue=1|year=2016|page=38126|issn=2045-2322|doi=10.1038/srep38126|pmid=27905512|pmc=5131480|bibcode=2016NatSR...638126J|doi-access=free}} (4) Research on different drug discovery projects, in particular in the field of neurodegenerative diseases such as ALS, Alzheimer, familial dysautonomia and the vanishing white material disease{{cite journal|last1=Atzmon|first1=Andrea|last2=Herrero|first2=Melisa|last3=Sharet-Eshed|first3=Reut|last4=Gilad|first4=Yocheved|last5=Senderowitz|first5=Hanoch|last6=Elroy-Stein|first6=Orna|title=Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy|journal=Frontiers in Molecular Neuroscience|volume=11|year=2018|page=336|issn=1662-5099|doi=10.3389/fnmol.2018.00336|pmid=30279648|pmc=6153319|doi-access=free}} as well as diabetes,{{cite journal|last1=Munder|first1=Anna|last2=Israel|first2=Liron L.|last3=Kahremany|first3=Shirin|last4=Ben-Shabat-Binyamini|first4=Rina|last5=Zhang|first5=Charles|last6=Kolitz-Domb|first6=Michal|last7=Viskind|first7=Olga|last8=Levine|first8=Anna|last9=Senderowitz|first9=Hanoch|last10=Chessler|first10=Steven|last11=Lellouche|first11=Jean-Paul|last12=Gruzman|first12=Arie|title=Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy|journal=ACS Applied Materials & Interfaces|volume=9|issue=2|year=2017|pages=1189–1206|issn=1944-8244|doi=10.1021/acsami.6b10568|pmid=28045486|pmc=6035049}} and calcification-related diseases and autoimmune disease.{{cite journal|last1=Getter|first1=Tamar|last2=Margalit|first2=Raanan|last3=Kahremany|first3=Shirin|last4=Levy|first4=Laura|last5=Blum|first5=Eliav|last6=Khazanov|first6=Netaly|last7=Keshet-Levy|first7=Nimrod Y.|last8=Tamir|first8=Tigist Y.|last9=Ben Major|first9=M.|last10=Lahav|first10=Ron|last11=Zilber|first11=Sofia|last12=Senderowitz|first12=Hanoch|last13=Bradfield|first13=Paul|last14=Imhof|first14=Beat A.|last15=Alpert|first15=Evgenia|last16=Gruzman|first16=Arie|title=Novel inhibitors of leukocyte transendothelial migration|journal=Bioorganic Chemistry|volume=92|year=2019|pages=103250|issn=0045-2068|doi=10.1016/j.bioorg.2019.103250|pmid=31580982|s2cid=203374442}}{{cite journal|last1=Trifonov|first1=Lena|last2=Nudelman|first2=Vadim|last3=Zhenin|first3=Michael|last4=Matsree|first4=Erez|last5=Afri|first5=Michal|last6=Schmerling|first6=Bruria|last7=Cohen|first7=Guy|last8=Jozwiak|first8=Krzysztof|last9=Weitman|first9=Michal|last10=Korshin|first10=Edward|last11=Senderowitz|first11=Hanoch|last12=Shainberg|first12=Asher|last13=Hochhauser|first13=Edith|last14=Gruzman|first14=Arie|title=Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model|journal=Journal of Medicinal Chemistry|volume=61|issue=24|year=2018|pages=11309–11326|issn=0022-2623|doi=10.1021/acs.jmedchem.8b01471|pmid=30507195|s2cid=54562681}}{{cite journal|last1=Zelikman|first1=Vadim|last2=Pelletier|first2=Julie|last3=Simhaev|first3=Luba|last4=Sela|first4=Aviad|last5=Gendron|first5=Fernand-Pierre|last6=Arguin|first6=Guillaume|last7=Senderowitz|first7=Hanoch|last8=Sévigny|first8=Jean|last9=Fischer|first9=Bilha|title=Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5′-Pα,α-Dithiophosphate Analogues|journal=Journal of Medicinal Chemistry|volume=61|issue=9|year=2018|pages=3939–3951|issn=0022-2623|doi=10.1021/acs.jmedchem.7b01906|pmid=29681152}}

He has over 90 peer-reviewed articles, and has contributed to various book chapters.{{cite book|last1=Momic|first1=Tatjana|last2=Katzehendler|first2=Jehoshua|last3=Noy|first3=Efrat|last4=Senderowitz|first4=Hanoch|last5=A. Eble|first5=Johannes|last6=Marcinkiewicz|first6=Cezary|last7=Lazarovici|first7=Philip|editor7-first=Philip|editor7-last=Lazarovici|editor6-first=Cezary|editor6-last=Marcinkiewicz|editor5-first=Johannes|editor5-last=a. Eble|editor4-first=Hanoch|editor4-last=Senderowitz|editor3-first=Efrat|editor3-last=Noy|editor2-first=Jehoshua|editor2-last=Katzehendler|editor1-first=Tatjana|editor1-last=Momic|title=Anti-Angiogenesis Drug Discovery and Development|chapter=Disintegrin-Based, Synthetic Cyclic KTS Peptides as Novel Dual Antagonists of α1β1/α2β1 Integrins with Antiangiogenic Activity|year=2016|pages=16–45|doi=10.2174/9781681081557116030004|isbn=9781681081557}}{{cite book|last1=Yosipof|first1=Abraham|last2=Senderowitz|first2=Hanoch|title=Optimization Algorithms - Methods and Applications|chapter=Optimization Algorithms for Chemoinformatics and Material-informatics|year=2016|doi=10.5772/62483|isbn=978-953-51-2592-1|doi-access=free}}{{cite book|author1=Arup Ghose|author2=Vellerkad Viswanadhan|title=Combinatorial Library Design and Evaluation: Principles, Software, Tools, and Applications in Drug Discovery|url=https://books.google.com/books?id=1VifwQp_crIC|date=26 June 2001|publisher=CRC Press|isbn=978-0-8247-0487-2}}{{cite book | last = Patai | first = Saul | title = The chemistry of amino, nitroso, nitro, and related groups | publisher = Wiley | location = Chichester England New York | year = 1996 | isbn = 978-0-471-95171-1 }}

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Category:Living people

Category:Israeli chemists

Category:Jewish chemists

Category:1963 births

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Category:Tel Aviv University alumni

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