Hepatitis A virus cis-acting replication element

In molecular biology, the hepatitis A virus cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase in hepatitis A virus (HAV). It is larger than the CREs found in related Picornavirus species, but is thought to be functionally similar. It is thought to be involved in uridylylation of VPg.{{cite journal|last=Yang|first=Y|author2=Yi, M |author3=Evans, DJ |author4=Simmonds, P |author5= Lemon, SM |title=Identification of a conserved RNA replication element (cre) within the 3Dpol-coding sequence of hepatoviruses.|journal=Journal of Virology|date=October 2008|volume=82|issue=20|pages=10118–28|pmid=18684812|doi=10.1128/jvi.00787-08 |pmc=2566277}}