Hippocampal sulcus
{{Infobox brain
| Name = Hippocampal sulcus
| Latin = sulcus hippocampalis,
sulcus hippocampi
| Image = Hippocampus (brain).jpg
| Caption = Hippocampal sulcus labeled at center.
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The hippocampal sulcus, also known as the hippocampal fissure, is a sulcus that separates the dentate gyrus from the subiculum and the CA1 field in the hippocampus.
Structure
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Development
[[File:Hippocampal sulcus remnants - MRT T2 axial - 001.jpg|thumb|
Hippocampal sulcus remnants seen on T2-weighted axial MRI image.
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During human fetal development, the hippocampal sulcus first appears at approximately 10 weeks of gestational age. At this stage it exists as a broad shallow fissure along the surface of the dentate gyrus. Gradually, the fissure deepens and shifts toward the cornu ammonis. After about 18 weeks, the walls of the fissure fold into each other and begin to fuse. By 30 weeks, the hippocampal sulcus is normally obliterated except for its most medial part, leaving a shallow surface indentation.Humphrey, Tryphena. "The development of the human hippocampal fissure". Journal of anatomy. 1967 September; 101(Pt 4): 655–676.
Clinical significance
Enlargement of the hippocampal sulcus has been associated with medial temporal lobe atrophy occurring in Alzheimer's disease.{{cite journal|vauthors=Bastos-Leite AJ, van Waesberghe JH, Oen AL, van der Flier WM, Scheltens P, Barkhof F |title=Hippocampal sulcus width and cavities: comparison between patients with Alzheimer disease and nondemented elderly subjects |journal=American Journal of Neuroradiology |volume=27 |issue=10 |pages=2141–5 |year=2006 |pmid=17110684|pmc=7977199 }}
See also
References
External links
{{Commons category|Hippocampal sulcus}}
- [https://www.neuinfo.org/mynif/search.php?q=Hippocampal%20sulcus&t=data&s=cover&b=0&r=20 NIF Search - Hippocampal sulcus] via the Neuroscience Information Framework
{{Cerebral cortex}}
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