Human Biomolecular Atlas Program

File:HubMap - Figure 1.png

The Human Biomolecular Atlas Program (HuBMAP) is a program funded by the US National Institutes of Health to characterize the human body at single cell resolution, integrated to other efforts such as the Human Cell Atlas.{{cite journal | vauthors = Snyder MP, Lin S, Posgai A, Atkinson M, Regev A, Rood J, etal | collaboration = HuBMAP Consortium | title = The human body at cellular resolution: the NIH Human Biomolecular Atlas Program | language = English | journal = Nature | volume = 574 | issue = 7777 | pages = 187–192 | date = October 2019 | pmid = 31597973 | pmc = 6800388 | doi = 10.1038/S41586-019-1629-X | bibcode = 2019Natur.574..187H }} Among the products of the program is the Azimuth reference datasets for single-cell RNA seq data {{cite journal | vauthors = Hao Y, Hao S, Andersen-Nissen E, Mauck WM, Zheng S, Butler A, Lee MJ, Wilk AJ, Darby C, Zager M, Hoffman P, Stoeckius M, Papalexi E, Mimitou EP, Jain J, Srivastava A, Stuart T, Fleming LM, Yeung B, Rogers AJ, McElrath JM, Blish CA, Gottardo R, Smibert P, Satija R | display-authors = 6 | title = Integrated analysis of multimodal single-cell data | journal = Cell | volume = 184 | issue = 13 | pages = 3573–3587.e29 | date = June 2021 | pmid = 34062119 | pmc = 8238499 | doi = 10.1016/j.cell.2021.04.048 }}{{Cite web |title=Azimuth |url=https://azimuth.hubmapconsortium.org/ |access-date=2022-07-11 |website=azimuth.hubmapconsortium.org |language=en-us |archive-date=2022-07-06 |archive-url=https://web.archive.org/web/20220706053958/https://azimuth.hubmapconsortium.org/ |url-status=live }} and the ASCT+B Reporter, a visualization tool for anatomical structures, cell types and biomarkers.{{Cite web |title=ASCT+B Reporter |url=https://ccf-asctb-reporter-v2.netlify.app/ |archive-url=https://web.archive.org/web/20211022130858/https://ccf-asctb-reporter-v2.netlify.app/ |url-status=dead |archive-date=October 22, 2021 |access-date=2022-07-11 |website=ccf-asctb-reporter-v2.netlify.app |language=en }}{{Cite journal | vauthors = Boppana A, Lee S, Malhotra R, Halushka M, Quardokus EM, Herr BW, Börner K, Weber GM |date=2022-03-01 |title=Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature | journal = bioRxiv |doi = 10.1101/2022.02.28.482302 |s2cid=247231648 |doi-access=free }}

Millitomes are used to create uniformly sized tissue blocks that match the shape and size of organs from HuBMAP's 3D Reference Object Library.{{Cite web |last=HIVE MC-IU Team |title=HuBMAP: CCF Portal |url=https://hubmapconsortium.github.io/ccf/pages/ccf-3d-reference-library.html |access-date=2022-08-27 |website=hubmapconsortium.github.io |language=en}}

The HuBMAP received 27 million US dollars of funding from the NIH in 2020 and about 28.5 million in 2021.{{Cite web |title=NIH Common Fund CONGRESSIONAL JUSTIFICATION FY 2022 |url=https://commonfund.nih.gov/sites/default/files/Common-Fund-FY-2022-CJ-508.pdf |access-date=2022-07-11 |archive-date=2021-11-05 |archive-url=https://web.archive.org/web/20211105050741/https://commonfund.nih.gov/sites/default/files/Common-Fund-FY-2022-CJ-508.pdf |url-status=live }}

File:HubMap - Figure 3.png and spatial trancriptomics.]]