Hydroxyethylrutoside
Hydroxyethylrutosides (oxerutins, O-beta-hydroxyethyl-rutosides, HR, or HER) are hydroxyethyl derivatives of rutosides. Examples include:
Oxerutins are semisynthetic derivatives of plant constituents. Although they are closely related to the natural flavonoid rutin, hydroxyethylrutosides are not found in food. The only way to take them is in a supplement.[http://healthlibrary.epnet.com/GetContent.aspx?token=e0498803-7f62-4563-8d47-5fe33da65dd4&chunkiid=21772 Oxerutins on healthlibrary.epnet.com]
Health benefits
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Relvène (1967 French version), Venoruton (1962 Swiss version), and Paroven are mixtures of hydroxyethyl rutinosides. Hydroxyethylrutosides are used in the treatment of chronic venous insufficiency{{cite journal |pmid=10744007 |year=2000 |last1=Frick |first1=RW |title=Three treatments for chronic venous insufficiency: Escin, hydroxyethylrutoside, and Daflon |volume=51 |issue=3 |pages=197–205 |journal=Angiology |doi=10.1177/000331970005100303|s2cid=19421726 }} and hypertensive microangiopathy.{{cite journal |pmid=12011966 |year=2002 |last1=Incandela |first1=L |last2=Belcaro |first2=G |last3=Renton |first3=S |last4=Desanctis |first4=MT |last5=Cesarone |first5=MR |last6=Bavera |first6=P |last7=Ippolito |first7=E |last8=Bucci |first8=M |last9=Griffin |first9=M |last10=Geroulakos |first10=G |last11=Dugall |first11=M |last12=Golden |first12=G |last13=Acerbi |first13=G |title=HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: A prospective, placebo-controlled, randomized trial |volume=7 |pages=S7–S10 |journal=Journal of Cardiovascular Pharmacology and Therapeutics|issue=Suppl 1 |display-authors=8 |doi=10.1177/107424840200700103|s2cid=9720685 }} Oxerutins work by reducing leakage from the small blood vessels (capillaries).[http://www.netdoctor.co.uk/medicines/100002021.html Paroven on netdoctor.co.uk]
Hydroxyethylrutosides have been used as an alternative to horse chestnut preparations (venostasin) containing aescin. Typical doses are in the order of 1,000 mg/day.[https://books.google.com/books?id=2XZY5eD5dPIC&pg=PA847 The handbook of clinically tested herbal remedies, Volume 2 by Marilyn Barrett]
Effects of hydroxyethylrutosides against adriamycin-induced toxicity have been investigated in rats.{{cite journal |pmid=4004421 |year=1985 |last1=Gulati |first1=OP |last2=Nordmann |first2=H |last3=Aellig |first3=A |last4=Maignan |first4=MF |last5=McGinness |first5=J |title=Protective effects of O-(beta-hydroxyethyl)-rutosides (HR) against adriamycin-induced toxicity in rats |volume=273 |issue=2 |pages=323–34 |journal=Archives Internationales de Pharmacodynamie et de Thérapie}}