IFT81
{{Infobox_gene}}
Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene.{{cite web | title = Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28981}}{{cite journal |vauthors=Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T | title = Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene | journal = Mamm. Genome | volume = 11 | issue = 12 | pages = 1053–7 |date=December 2000 | pmid = 11130971 | doi = 10.1007/s003350010207| s2cid = 9319574 }} Together with IFT74/72 it forms a core complex to build IFT particles{{cite journal |vauthors=Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG | title = Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits | journal = J. Biol. Chem. | volume = 280 | issue = 30 | pages = 27688–96 |date=July 2005 | pmid = 15955805 | doi = 10.1074/jbc.M505062200 | doi-access = free }} which are required for cilium formation. Additionally, it interacts with basal body components as CEP170{{Cite thesis | title = Functional characterisation of the centrosomal protein Cep170 | url = http://edoc.ub.uni-muenchen.de/9783/ | last = Lamla | first = Stefan | year = 2009 | publisher = LMU München: Faculty of Biology }} which regulates the disassembly of the cilium.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Melzer D, Perry JR, Hernandez D, etal |title=A genome-wide association study identifies protein quantitative trait loci (pQTLs). |journal=PLOS Genet. |volume=4 |issue= 5 |pages= e1000072 |year= 2008 |pmid= 18464913 |doi= 10.1371/journal.pgen.1000072 |editor1-last=Cheung |editor1-first=Vivian G. |pmc=2362067 |doi-access=free }} {{open access}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Peng J, Yu L, Horiuchi M, etal |title=Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation |journal=Mol. Biol. Rep. |volume=29 |issue= 4 |pages= 353–62 |year= 2002 |pmid= 12549821 |doi= 10.1023/A:1021232518628 |s2cid=908688 }}
- {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 |pmc=515316}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{refend}}
{{gene-12-stub}}