IGBP1

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.

IGBP1 has been shown to interact with PPP4C,{{cite journal | vauthors = Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 43 | pages = 29273–84 | date = Oct 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 | doi-access = free }}{{cite journal | vauthors = Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R | title = A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 11 | pages = 1725–40 | date = Nov 2005 | pmid = 16085932 | doi = 10.1074/mcp.M500231-MCP200 | s2cid = 7531012 | doi-access = free }}{{cite journal | vauthors = Chen J, Peterson RT, Schreiber SL | title = Alpha 4 associates with protein phosphatases 2A, 4, and 6 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 827–32 | date = Jun 1998 | pmid = 9647778 | doi = 10.1006/bbrc.1998.8792 }} PPP6C and PPP2CA.{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Molecular & Cellular Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 | doi-access = free }}{{cite journal | vauthors = Chung H, Nairn AC, Murata K, Brautigan DL | title = Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2 | journal = Biochemistry | volume = 38 | issue = 32 | pages = 10371–6 | date = Aug 1999 | pmid = 10441131 | doi = 10.1021/bi990902g }}

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• {{cite journal | vauthors = Chen J, Peterson RT, Schreiber SL | title = Alpha 4 associates with protein phosphatases 2A, 4, and 6 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 827–32 | date = Jun 1998 | pmid = 9647778 | doi = 10.1006/bbrc.1998.8792 }}
• {{cite journal | vauthors = Chung H, Nairn AC, Murata K, Brautigan DL | title = Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2 | journal = Biochemistry | volume = 38 | issue = 32 | pages = 10371–6 | date = Aug 1999 | pmid = 10441131 | doi = 10.1021/bi990902g }}
• {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = International Journal of Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 | doi-access = free }}
• {{cite journal | vauthors = Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL | title = Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 12 | pages = 6650–5 | date = Jun 2001 | pmid = 11371618 | pmc = 34408 | doi = 10.1073/pnas.111154698 | bibcode = 2001PNAS...98.6650L | doi-access = free }}
• {{cite journal | vauthors = Short KM, Hopwood B, Yi Z, Cox TC | title = MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders | journal = BMC Cell Biology | volume = 3 | pages = 1 | year = 2002 | pmid = 11806752 | pmc = 64779 | doi = 10.1186/1471-2121-3-1 | doi-access = free }}
• {{cite journal | vauthors = Graham JM, Wheeler P, Tackels-Horne D, Lin AE, Hall BD, May M, Short KM, Schwartz CE, Cox TC | title = A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13 | journal = American Journal of Medical Genetics Part A | volume = 123A | issue = 1 | pages = 37–44 | date = Nov 2003 | pmid = 14556245 | doi = 10.1002/ajmg.a.20504 | s2cid = 26545089 }}
• {{cite journal | vauthors = Smetana JH, Oliveira CL, Jablonka W, Aguiar Pertinhez T, Carneiro FR, Montero-Lomeli M, Torriani I, Zanchin NI | title = Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42 | journal = Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | volume = 1764 | issue = 4 | pages = 724–34 | date = Apr 2006 | pmid = 16517231 | doi = 10.1016/j.bbapap.2006.01.018 }}

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