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IGF2BP1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.{{cite journal |vauthors=Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC | title = A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development | journal = Mol Cell Biol | volume = 19 | issue = 2 | pages = 1262–70 |date=Feb 1999 | pmid = 9891060 | pmc = 116055 | doi = 10.1128/MCB.19.2.1262}}{{cite journal |vauthors=Yaniv K, Yisraeli JK | title = The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis | journal = Gene | volume = 287 | issue = 1–2 | pages = 49–54 |date=May 2002 | pmid = 11992722 | doi =10.1016/S0378-1119(01)00866-6 | doi-access = free }}{{cite web | title = Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10642}}

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.

See also

References

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Further reading

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  • {{cite journal |vauthors=Perycz M, Urbanska AS, Krawczyk P, Parobczak K, Jaworski J |title=Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons |journal=J. Neurosci. |volume=31 |issue= 14 |pages= 5271–85 |year= 2011 |pmid= 21471362 |doi= 10.1523/JNEUROSCI.2387-10.2011 |pmc=6622686 |doi-access= free }}
  • {{cite journal | author=Yisraeli JK |title=VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins |journal=Biol. Cell |volume=97 |issue= 1 |pages= 87–96 |year= 2005 |pmid= 15601260 |doi= 10.1042/BC20040151 |s2cid=8767105 |doi-access=free }}
  • {{cite journal |vauthors=Prokipcak RD, Herrick DJ, Ross J |title=Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA |journal=J. Biol. Chem. |volume=269 |issue= 12 |pages= 9261–9 |year= 1994 |doi=10.1016/S0021-9258(17)37102-8 |pmid= 8132663 |doi-access=free }}
  • {{cite journal | author=Doyle GA |title=The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins |journal=Nucleic Acids Res. |volume=26 |issue= 22 |pages= 5036–44 |year= 1999 |pmid= 9801297 |doi=10.1093/nar/26.22.5036 | pmc=147974 |name-list-style=vanc| author2=Betz NA | author3=Leeds PF | display-authors=3 | last4=Fleisig | first4=AJ | last5=Prokipcak | first5=RD | last6=Ross | first6=J }}
  • {{cite journal | author=Runge S |title=H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29562–9 |year= 2000 |pmid= 10875929 |doi= 10.1074/jbc.M001156200 |name-list-style=vanc| author2=Nielsen FC | author3=Nielsen J | display-authors=3 | last4=Lykke-Andersen | first4=J | last5=Wewer | first5=UM | last6=Christiansen | first6=J | doi-access=free}}
  • {{cite journal | author=Nielsen FC |title=Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains |journal=J. Cell Sci. |volume=115 |issue= Pt 10 |pages= 2087–97 |year= 2003 |pmid= 11973350 |name-list-style=vanc| author2=Nielsen J | author3=Kristensen MA | display-authors=3 | last4=Koch | first4=G | last5=Christiansen | first5=J |doi=10.1242/jcs.115.10.2087 }}
  • {{cite journal |vauthors=Lemm I, Ross J |title=Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 3959–69 |year= 2002 |pmid= 12024010 |doi=10.1128/MCB.22.12.3959-3969.2002 | pmc=133878 }}
  • {{cite journal | author=Ioannidis P |title=8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas |journal=Int. J. Cancer |volume=104 |issue= 1 |pages= 54–9 |year= 2003 |pmid= 12532419 |doi= 10.1002/ijc.10794 |name-list-style=vanc| author2=Mahaira L | author3=Papadopoulou A | display-authors=3 | last4=Teixeira | first4=Manuel R. | last5=Heim | first5=Sverre | last6=Andersen | first6=Johan A. | last7=Evangelou | first7=Evangelos | last8=Dafni | first8=Urania | last9=Pandis | first9=Nikos |s2cid=45119038 | doi-access=free }}
  • {{cite journal | author=Nielsen J |title=Nuclear transit of human zipcode-binding protein IMP1 |journal=Biochem. J. |volume=376 |issue= Pt 2 |pages= 383–91 |year= 2003 |pmid= 12921532 |doi= 10.1042/BJ20030943 | pmc=1223771 |name-list-style=vanc| author2=Adolph SK | author3=Rajpert-De Meyts E | display-authors=3 | last4=Lykke-Andersen | first4=Jens | last5=Koch | first5=Grete | last6=Christiansen | first6=Jan | last7=Nielsen | first7=Finn C. }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal |vauthors=Gu L, Shigemasa K, Ohama K |title=Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer |journal=Int. J. Oncol. |volume=24 |issue= 3 |pages= 671–8 |year= 2004 |pmid= 14767552 |doi= 10.3892/ijo.24.3.671}}
  • {{cite journal | author=Hansen TV |title=Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice |journal=Mol. Cell. Biol. |volume=24 |issue= 10 |pages= 4448–64 |year= 2004 |pmid= 15121863 |doi=10.1128/MCB.24.10.4448-4464.2004 | pmc=400488 |name-list-style=vanc| author2=Hammer NA | author3=Nielsen J | display-authors=3 | last4=Madsen | first4=M. | last5=Dalbaeck | first5=C. | last6=Wewer | first6=U. M. | last7=Christiansen | first7=J. | last8=Nielsen | first8=F. C. }}
  • {{cite journal | author=Ioannidis P |title=Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors |journal=Cancer Lett. |volume=209 |issue= 2 |pages= 245–50 |year= 2004 |pmid= 15159028 |doi= 10.1016/j.canlet.2003.12.015 |name-list-style=vanc| author2=Kottaridi C | author3=Dimitriadis E | display-authors=3 | last4=Courtis | first4=Nelly | last5=Mahaira | first5=Louiza | last6=Talieri | first6=Maroulio | last7=Giannopoulos | first7=Andreas | last8=Iliadis | first8=Kosmas | last9=Papaioannou | first9=Dimitrios }}
  • {{cite journal |vauthors=Rackham O, Brown CM |title=Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs |journal=EMBO J. |volume=23 |issue= 16 |pages= 3346–55 |year= 2005 |pmid= 15282548 |doi= 10.1038/sj.emboj.7600341 | pmc=514514 }}
  • {{cite journal | author=Nielsen J |title=Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability |journal=Nucleic Acids Res. |volume=32 |issue= 14 |pages= 4368–76 |year= 2004 |pmid= 15314207 |doi= 10.1093/nar/gkh754 | pmc=514376 |name-list-style=vanc| author2=Kristensen MA | author3=Willemoës M | display-authors=3 | last4=Nielsen | first4=FC | last5=Christiansen | first5=J }}
  • {{cite journal | author=Suzuki Y |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |name-list-style=vanc| author2=Yamashita R | author3=Shirota M | display-authors=3 | last4=Sakakibara | first4=Y | last5=Chiba | first5=J | last6=Mizushima-Sugano | first6=J | last7=Nakai | first7=K | last8=Sugano | first8=S }}
  • {{cite journal | author=Liao B |title=Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 48716–24 |year= 2005 |pmid= 15355996 |doi= 10.1074/jbc.M405853200 |name-list-style=vanc| author2=Patel M | author3=Hu Y | display-authors=3 | last4=Charles | first4=S | last5=Herrick | first5=DJ | last6=Brewer | first6=G | doi-access=free}}

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