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IGF2BP2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.{{cite journal |vauthors=Zhang JY, Chan EK, Peng XX, Tan EM | title = A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma | journal = J Exp Med | volume = 189 | issue = 7 | pages = 1101–10 |date=May 1999 | pmid = 10190901 | pmc = 2193003 | doi =10.1084/jem.189.7.1101 }}{{cite journal |vauthors=Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC | title = A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development | journal = Mol Cell Biol | volume = 19 | issue = 2 | pages = 1262–70 |date=Feb 1999 | pmid = 9891060 | pmc = 116055 | doi = 10.1128/MCB.19.2.1262}}{{cite web | title = Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10644| accessdate = }}

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.{{cite web | title = Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10644| accessdate = }}

See also

References

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Further reading

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  • {{cite journal | author=Yisraeli JK |title=VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. |journal=Biol. Cell |volume=97 |issue= 1 |pages= 87–96 |year= 2005 |pmid= 15601260 |doi= 10.1042/BC20040151 |s2cid=8767105 |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Moraes KC, Quaresma AJ, Maehnss K, Kobarg J |title=Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D). |journal=Biol. Chem. |volume=384 |issue= 1 |pages= 25–37 |year= 2003 |pmid= 12674497 |doi=10.1515/BC.2003.004 |s2cid=30993043 }}
  • {{cite journal |vauthors=Brants JR, Ayoubi TA, Chada K, etal |title=Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. |journal=FEBS Lett. |volume=569 |issue= 1–3 |pages= 277–83 |year= 2004 |pmid= 15225648 |doi= 10.1016/j.febslet.2004.05.075 |s2cid=31167314 |doi-access=free }}
  • {{cite journal |vauthors=Ping S, Wang S, Zhang J, Peng X |title=Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells |journal=Int. J. Biochem. Cell Biol. |volume=37 |issue= 3 |pages= 616–27 |year= 2005 |pmid= 15618018 |doi= 10.1016/j.biocel.2004.08.007 }}
  • {{cite journal |vauthors=Hammer NA, Hansen TO, Byskov AG, etal |title=Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer |journal=Reproduction |volume=130 |issue= 2 |pages= 203–12 |year= 2005 |pmid= 16049158 |doi= 10.1530/rep.1.00664 |doi-access= free }}
  • {{cite journal |vauthors=Natkunam Y, Vainer G, Chen J, etal |title=Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms |journal=Haematologica |volume=92 |issue= 2 |pages= 176–83 |year= 2007 |pmid= 17296566 |doi=10.3324/haematol.10724 |doi-access=free }}
  • {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
  • {{cite journal |vauthors=Cleynen I, Brants JR, Peeters K, etal |title=HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB |journal=Mol. Cancer Res. |volume=5 |issue= 4 |pages= 363–72 |year= 2007 |pmid= 17426251 |doi= 10.1158/1541-7786.MCR-06-0331 |doi-access= |s2cid=21026667 }}

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