IGKC

{{Short description|Gene in the species Homo sapiens}}

{{Infobox_gene}}

Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains for antibodies.{{cite web | title = Entrez Gene: IGKC immunoglobulin kappa constant| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3514}} It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@.

References

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Further reading

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  • {{cite journal | author=Brady RL |title=Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells |journal=J. Mol. Biol. |volume=227 |issue= 1 |pages= 253–64 |year= 1992 |pmid= 1522589 |doi=10.1016/0022-2836(92)90695-G |name-list-style=vanc| author2=Edwards DJ | author3=Hubbard RE | display-authors=3 | last4=Jiang | first4=JS | last5=Lange | first5=G | last6=Roberts | first6=SM | last7=Todd | first7=RJ | last8=Adair | first8=JR | last9=Emtage | first9=JS }}
  • {{cite journal |vauthors=Titani K, Shinoda T, Putnam FW |title=The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges |journal=J. Biol. Chem. |volume=244 |issue= 13 |pages= 3550–60 |year= 1969 |doi=10.1016/S0021-9258(18)83405-6 |pmid= 4893682 |doi-access=free }}
  • {{cite journal |vauthors=Gall WE, Edelman GM |title=The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds |journal=Biochemistry |volume=9 |issue= 16 |pages= 3188–96 |year= 1971 |pmid= 4923144 |doi=10.1021/bi00818a011 }}
  • {{cite journal |vauthors=Suter L, Barnikol HU, Watanabe S, Hilschmann N |title=[Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production] |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=353 |issue= 2 |pages= 189–208 |year= 1972 |pmid= 5027703 }}
  • {{cite journal |vauthors=Kohler H, Shimizu A, Paul C, Putnam FW |title=Macroglobulin structure: variable sequence of light and heavy chains |journal=Science |volume=169 |issue= 3940 |pages= 56–9 |year= 1970 |pmid= 5447531 |doi=10.1126/science.169.3940.56 |bibcode=1970Sci...169...56K |s2cid=28925175 }}
  • {{cite journal |vauthors=Gottlieb PD, Cunningham BA, Rutishauser U, Edelman GM |title=The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain |journal=Biochemistry |volume=9 |issue= 16 |pages= 3155–61 |year= 1971 |pmid= 5489770 |doi=10.1021/bi00818a007 }}
  • {{cite journal | author=Hilschmann N |title=[The complete amino acid sequence of Bence Jones protein Cum (kappa-type)] |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=348 |issue= 12 |pages= 1718–22 |year= 1968 |pmid= 5586923 }}
  • {{cite journal |vauthors=Klobeck HG, Combriato G, Zachau HG |title=Immunoglobulin genes of the kappa light chain type from two human lymphoid cell lines are closely related |journal=Nucleic Acids Res. |volume=12 |issue= 18 |pages= 6995–7006 |year= 1984 |pmid= 6091049 |doi=10.1093/nar/12.18.6995 | pmc=320138 }}
  • {{cite journal |vauthors=Hieter PA, Maizel JV, Leder P |title=Evolution of human immunoglobulin kappa J region genes |journal=J. Biol. Chem. |volume=257 |issue= 3 |pages= 1516–22 |year= 1982 |doi=10.1016/S0021-9258(19)68223-2 |pmid= 6276389 |doi-access=free }}
  • {{cite journal | author=Emorine L |title=A conserved sequence in the immunoglobulin J kappa-C kappa intron: possible enhancer element |journal=Nature |volume=304 |issue= 5925 |pages= 447–9 |year= 1983 |pmid= 6308460 |doi=10.1038/304447a0 |name-list-style=vanc| author2=Kuehl M | author3=Weir L | display-authors=3 | last4=Leder | first4=Philip | last5=Max | first5=Edward E. |bibcode=1983Natur.304..447E |s2cid=4304624 }}
  • {{cite journal |vauthors=Bentley DL, Rabbitts TH |title=Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V kappa sequences have diverged by gene conversion |journal=Cell |volume=32 |issue= 1 |pages= 181–9 |year= 1983 |pmid= 6402305 |doi=10.1016/0092-8674(83)90508-1 |s2cid=21573834 }}
  • {{cite journal | author=Hieter PA |title=Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments |journal=Cell |volume=22 |issue= 1 Pt 1 |pages= 197–207 |year= 1981 |pmid= 6775818 |doi=10.1016/0092-8674(80)90168-3 |name-list-style=vanc| author2=Max EE | author3=Seidman JG | display-authors=3 | last4=Maizel | first4=Jacob V. | last5=Leder | first5=Philip |s2cid=24073515 }}
  • {{cite journal |vauthors=Bentley DL, Rabbits TH |title=Human immunoglobulin variable region genes--DNA sequences of two V kappa genes and a pseudogene |journal=Nature |volume=288 |issue= 5792 |pages= 730–3 |year= 1981 |pmid= 6779204 |doi=10.1038/288730a0 |s2cid=4321131 }}
  • {{cite journal | author=Huber C |title=The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line |journal=Eur. J. Immunol. |volume=23 |issue= 11 |pages= 2868–75 |year= 1993 |pmid= 8223863 |doi=10.1002/eji.1830231121 |name-list-style=vanc| author2=Schäble KF | author3=Huber E | display-authors=3 | last4=Klein | first4=Ralph | last5=Meindl | first5=Alfons | last6=Thiebe | first6=Rainer | last7=Lamm | first7=Rosemarie | last8=Zachau | first8=Hans G. |s2cid=85005411 }}
  • {{cite journal |vauthors=Olsen KE, Sletten K, Westermark P |title=Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 3 |pages= 713–6 |year= 1998 |pmid= 9588180 |doi= 10.1006/bbrc.1998.8515 }}
  • {{cite journal | author=Wally J |title=Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain |journal=Biochim. Biophys. Acta |volume=1454 |issue= 1 |pages= 49–56 |year= 1999 |pmid= 10354514 |doi= 10.1016/s0925-4439(99)00019-8|name-list-style=vanc| author2=Kica G | author3=Zhang Y | display-authors=3 | last4=Ericsson | first4=T | last5=Connors | first5=LH | last6=Benson | first6=MD | last7=Liepnieks | first7=JJ | last8=Murray | first8=J | last9=Skinner | first9=M | doi-access=free }}
  • {{cite journal | author=Hotta K |title=Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8 |journal=J. Mol. Biol. |volume=302 |issue= 5 |pages= 1213–25 |year= 2000 |pmid= 11183784 |doi= 10.1006/jmbi.2000.4503 |name-list-style=vanc| author2=Lange H | author3=Tantillo DJ | display-authors=3 | last4=Houk | first4=K.N. | last5=Hilvert | first5=Donald | last6=Wilson | first6=Ian A. }}
  • {{cite journal | author=Karpusas M |title=Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody |journal=Structure |volume=9 |issue= 4 |pages= 321–9 |year= 2001 |pmid= 11525169 |doi=10.1016/S0969-2126(01)00590-1 |name-list-style=vanc| author2=Lucci J | author3=Ferrant J | display-authors=3 | last4=Benjamin | first4=Christopher | last5=Taylor | first5=Frederick R. | last6=Strauch | first6=Kathy | last7=Garber | first7=Ellen | last8=Hsu | first8=Yen-Ming | doi-access=free }}
  • {{cite journal | author=Davis DP |title=Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain |journal=J. Mol. Biol. |volume=313 |issue= 5 |pages= 1021–34 |year= 2001 |pmid= 11700059 |doi= 10.1006/jmbi.2001.5092 |name-list-style=vanc| author2=Gallo G | author3=Vogen SM | display-authors=3 | last4=Dul | first4=JL | last5=Sciarretta | first5=KL | last6=Kumar | first6=A | last7=Raffen | first7=R | last8=Stevens | first8=FJ | last9=Argon | first9=Y }}
  • {{cite journal |vauthors=Pandey JP, Frederick M |title=TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis |journal=Hum. Immunol. |volume=63 |issue= 6 |pages= 485–91 |year= 2002 |pmid= 12039524 |doi=10.1016/S0198-8859(02)00399-3 }}

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Category:Proteins

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