IRF2

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.{{cite web | title = Entrez Gene: IRF2 interferon regulatory factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3660}}

• IRF1
• Interferon regulatory factors

IRF2 has been shown to interact with BRD7,{{cite journal | vauthors = Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ | title = Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 | journal = J. Cell. Physiol. | volume = 185 | issue = 2 | pages = 269–79 | date = November 2000 | pmid = 11025449 | doi = 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L | s2cid = 22932901 }} EP300{{cite journal | vauthors = Masumi A, Ozato K | title = Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 20973–80 | date = June 2001 | pmid = 11304541 | doi = 10.1074/jbc.M101707200 | doi-access = free }} and PCAF.{{cite journal | vauthors = Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K | title = The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 1810–20 | date = March 1999 | pmid = 10022868 | pmc = 83974 | doi = 10.1128/MCB.19.3.1810 }}

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• {{cite journal | vauthors = Harada H, Taniguchi T, Tanaka N | title = The role of interferon regulatory factors in the interferon system and cell growth control | journal = Biochimie | volume = 80 | issue = 8–9 | pages = 641–50 | year = 1999 | pmid = 9865486 | doi = 10.1016/S0300-9084(99)80017-0 }}
• {{cite journal | vauthors = Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA | title = Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth | journal = Biochimie | volume = 80 | issue = 8–9 | pages = 651–8 | year = 1999 | pmid = 9865487 | doi = 10.1016/S0300-9084(99)80018-2 | doi-access = free }}
• {{cite journal | vauthors = Itoh S, Harada H, Fujita T, Mimura T, Taniguchi T | title = Sequence of a cDNA coding for human IRF-2 | journal = Nucleic Acids Res. | volume = 17 | issue = 20 | pages = 8372 | year = 1989 | pmid = 2813069 | pmc = 334978 | doi = 10.1093/nar/17.20.8372 }}
• {{cite journal | vauthors = Harada H, Takahashi E, Itoh S, Harada K, Hori TA, Taniguchi T | title = Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system | journal = Mol. Cell. Biol. | volume = 14 | issue = 2 | pages = 1500–9 | year = 1994 | pmid = 7507207 | pmc = 358505 | doi = 10.1128/MCB.14.2.1500}}
• {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | year = 1995 | pmid = 7566098 | doi = | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf }}
• {{cite journal | vauthors = Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ | title = Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors | journal = J. Biol. Chem. | volume = 270 | issue = 22 | pages = 13063–9 | year = 1995 | pmid = 7768900 | doi = 10.1074/jbc.270.22.13063 | doi-access = free }}
• {{cite journal | vauthors = Cha Y, Deisseroth AB | title = Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region | journal = J. Biol. Chem. | volume = 269 | issue = 7 | pages = 5279–87 | year = 1994 | doi = 10.1016/S0021-9258(17)37685-8 | pmid = 8106512 | doi-access = free }}
• {{cite journal | vauthors = Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M, Taniguchi T | title = Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2 | journal = Science | volume = 259 | issue = 5097 | pages = 971–4 | year = 1993 | pmid = 8438157 | doi = 10.1126/science.8438157 | bibcode = 1993Sci...259..971H | s2cid = 41036818 }}
• {{cite journal | vauthors = Drew PD, Franzoso G, Carlson LM, Biddison WE, Siebenlist U, Ozato K | title = Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells | journal = J. Neuroimmunol. | volume = 63 | issue = 2 | pages = 157–62 | year = 1996 | pmid = 8550813 | doi = 10.1016/0165-5728(95)00140-9 | s2cid = 53166594 | url = https://zenodo.org/record/1258359 }}
• {{cite journal | vauthors = Birnbaum MJ, van Zundert B, Vaughan PS, Whitmarsh AJ, van Wijnen AJ, Davis RJ, Stein GS, Stein JL | title = Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo | journal = J. Cell. Biochem. | volume = 66 | issue = 2 | pages = 175–83 | year = 1997 | pmid = 9213219 | doi = 10.1002/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N | s2cid = 34485265 }}
• {{cite journal | vauthors = Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K | title = The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 1810–20 | year = 1999 | pmid = 10022868 | pmc = 83974 | doi = 10.1128/MCB.19.3.1810}}
• {{cite journal | vauthors = Li W, Nagineni CN, Hooks JJ, Chepelinsky AB, Egwuagu CE | title = Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors | journal = Invest. Ophthalmol. Vis. Sci. | volume = 40 | issue = 5 | pages = 976–82 | year = 1999 | pmid = 10102295 }}
• {{cite journal | vauthors = Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland HF, Biddison WE | title = Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays | journal = Ann. Neurol. | volume = 46 | issue = 3 | pages = 425–8 | year = 1999 | pmid = 10482277 | doi = 10.1002/1531-8249(199909)46:3<425::AID-ANA22>3.0.CO;2-O | s2cid = 85574347 }}
• {{cite journal | vauthors = Mild GC, Schmahl GE, Shayan P, Niemeyer CM | title = Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia | journal = Leuk. Lymphoma | volume = 35 | issue = 5–6 | pages = 507–11 | year = 2000 | pmid = 10609788 | doi = 10.1080/10428199909169615 }}
• {{cite journal | vauthors = Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ | title = Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 | journal = J. Cell. Physiol. | volume = 185 | issue = 2 | pages = 269–79 | year = 2000 | pmid = 11025449 | doi = 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L | s2cid = 22932901 }}
• {{cite journal | vauthors = Larrea E, Alberdi A, Castelruiz Y, Boya P, Civeira MP, Prieto J | title = Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5 | journal = J. Viral Hepat. | volume = 8 | issue = 2 | pages = 103–10 | year = 2001 | pmid = 11264730 | doi = 10.1046/j.1365-2893.2001.00273.x | s2cid = 55595193 }}
• {{cite journal | vauthors = Masumi A, Ozato K | title = Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 20973–80 | year = 2001 | pmid = 11304541 | doi = 10.1074/jbc.M101707200 | doi-access = free }}

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• {{Commonscatinline|Interferon regulatory factor-2, IRF-2}}
• {{MeshName|IRF2+protein,+human}}

{{NLM content}}

{{PDB Gallery|geneid=3660}}

{{Transcription factors|g3}}

{{JAK-STAT signaling pathway}}

Category:Transcription factors

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