Immunologic activation
{{Short description|Transition of leucocytes in immune system}}
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In immunology, activation is the transition of leucocytes and other cell types involved in the immune system. On the other hand, deactivation is the transition in the reverse direction.{{Cite journal |last1=Kane |first1=Barry A. |last2=Bryant |first2=Katherine J. |last3=McNeil |first3=H. Patrick |last4=Tedla |first4=Nicodemus T. |date=2014 |title=Termination of immune activation: an essential component of healthy host immune responses |journal=Journal of Innate Immunity |volume=6 |issue=6 |pages=727–738 |doi=10.1159/000363449 |issn=1662-8128 |pmc=6741560 |pmid=25033984}} This balance is tightly regulated, since a too small degree of activation causes susceptibility to infections, while, on the other hand, a too large degree of activation causes autoimmune diseases.
Factors
Activation and deactivation results from a variety of factors, including cytokines, soluble receptors, arachidonic acid metabolites, steroids, receptor antagonists, adhesion molecules, bacterial products and viral products.
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|+ Overview of activating and deactivating factors. ! !! Activation !! Deactivation |
| Cytokines
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| Soluble receptors
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| Arachidonic acid metabolites
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| Steroids
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| Receptor antagonists
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| Adhesion molecules
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| Bacterial products
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| Viral products
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See also
References
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