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Integrin alpha 3

{{Short description|Mammalian protein found in Homo sapiens}}

{{Refimprove|date=January 2008}}

{{Infobox_gene}}

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.{{cite journal | vauthors = Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME | title = Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen | journal = J Cell Biol | volume = 115 | issue = 1 | pages = 257–66 | date = October 1991 | pmid = 1655803 | pmc = 2289928 | doi = 10.1083/jcb.115.1.257 }}{{cite journal | vauthors = Jones SD, van der Flier A, Sonnenberg A | title = Genomic organization of the human alpha 3 integrin subunit gene | journal = Biochem Biophys Res Commun | volume = 248 | issue = 3 | pages = 896–8 | date = September 1998 | pmid = 9704023 | doi = 10.1006/bbrc.1998.9071 }}

ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').{{cite web | title = Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3675}}

Interactions

CD49c has been shown to interact with:

  • CD9{{cite journal | vauthors = Park KR, Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S | title = CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1) | journal = Mol. Hum. Reprod. | volume = 6 | issue = 3 | pages = 252–7 | date = March 2000 | pmid = 10694273 | doi = 10.1093/molehr/6.3.252| doi-access = free }}{{cite journal | vauthors = Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S | title = CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5 | journal = Mol. Hum. Reprod. | volume = 5 | issue = 2 | pages = 162–7 | date = February 1999 | pmid = 10065872 | doi = 10.1093/molehr/5.2.162| doi-access = free }}
  • FHL2,{{cite journal | vauthors = Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M | title = The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes | journal = J. Biol. Chem. | volume = 275 | issue = 43 | pages = 33669–78 | date = October 2000 | pmid = 10906324 | doi = 10.1074/jbc.M002519200 | doi-access = free }}
  • LGALS8,{{cite journal | vauthors = Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y | title = Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis | journal = J. Cell Sci. | volume = 113 | issue = 13| pages = 2385–97 | date = July 2000 | doi = 10.1242/jcs.113.13.2385 | pmid = 10852818 }} and
  • TSPAN4.{{cite journal | vauthors = Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME | title = NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins | journal = J. Biol. Chem. | volume = 272 | issue = 46 | pages = 29181–9 | date = November 1997 | pmid = 9360996 | doi = 10.1074/jbc.272.46.29181| doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Bosman FT | title = Integrins: cell adhesives and modulators of cell function. | journal = Histochem. J. | volume = 25 | issue = 7 | pages = 469–77 | year = 1993 | pmid = 8407358 | doi = 10.1007/BF00159282 | s2cid = 19661102 }}
  • {{cite journal | vauthors = Fornaro M, Languino LR | title = Alternatively spliced variants: a new view of the integrin cytoplasmic domain. | journal = Matrix Biol. | volume = 16 | issue = 4 | pages = 185–93 | year = 1998 | pmid = 9402008 | doi = 10.1016/S0945-053X(97)90007-X | doi-access = free }}

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External links

  • {{MeshName|CD49c+antigen}}
  • [https://archive.today/20130414110534/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=3675 ITGA3] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway] {{Webarchive|url=https://web.archive.org/web/20141211173306/http://www.cellmigration.org/index.shtml |date=2014-12-11 }}
  • {{UCSC gene info|ITGA3}}

{{Clusters of differentiation}}

{{Integrins}}

Category:Integrins

Category:Clusters of differentiation

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