Integrin alpha 6

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.{{cite web | title = Entrez Gene: ITGA6 integrin, alpha 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655}} Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.{{cite journal | vauthors = De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, Méchine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E | display-authors = 6 | title = Hemidesmosome integrity protects the colon against colitis and colorectal cancer | journal = Gut | volume = 66 | issue = 10 | pages = 1748–1760 | date = October 2017 | pmid = 27371534 | pmc = 5595104 | doi = 10.1136/gutjnl-2015-310847 }}

ITGA6 has been shown to interact with TSPAN4{{cite journal | vauthors = Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME | title = NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins | journal = The Journal of Biological Chemistry | volume = 272 | issue = 46 | pages = 29181–9 | date = November 1997 | pmid = 9360996 | doi = 10.1074/jbc.272.46.29181 | doi-access = free }} and GIPC1.{{cite journal | vauthors = Tani TT, Mercurio AM | title = PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B | journal = The Journal of Biological Chemistry | volume = 276 | issue = 39 | pages = 36535–42 | date = September 2001 | pmid = 11479315 | doi = 10.1074/jbc.M105785200 | doi-access = free }}

• Cluster of differentiation
• Integrins

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• {{cite journal | vauthors = Lipscomb EA, Mercurio AM | title = Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression | journal = Cancer and Metastasis Reviews | volume = 24 | issue = 3 | pages = 413–23 | date = September 2005 | pmid = 16258729 | doi = 10.1007/s10555-005-5133-4 | s2cid = 26150860 }}

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• {{MeshName|CD49f+Antigen}}
• [https://archive.today/20130414105620/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=3655 ITGA6] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway] {{Webarchive|url=https://web.archive.org/web/20141211173306/http://www.cellmigration.org/index.shtml |date=11 December 2014 }}

{{Clusters of differentiation}}

{{Integrins}}

{{DEFAULTSORT:Integrin alpha 6}}

Category:Integrins

Category:Clusters of differentiation

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