James Briscoe
{{Short description|Senior group leader at the Francis Crick Institute in London}}
{{For|the footballers|Jim Briscoe|Jimmy Briscoe}}
{{Infobox scientist
| name = James Briscoe
| honorific_suffix = {{post-nominals|country=GBR|FRS|FMedSci|size=100%}}
| native_name =
| native_name_lang =
| image =
| image_size =
| image_upright =
| alt =
| caption =
| birth_name =
| birth_date =
| birth_place =
| fields = Developmental biology{{Google scholar id}}
| workplaces = Francis Crick Institute
Columbia University
National Institute for Medical Research
| patrons =
| education =
| alma_mater = University of Warwick
King's College London
| thesis_title = JAKs, STATs and signal transduction in response to the interferons and interleukin-6
| thesis_url = https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336443
| thesis_year = 1996
| doctoral_advisor = Ian M. Kerr
| academic_advisors =
| doctoral_students =
| notable_students =
| known_for =
| awards = EMBO Gold Medal (2008)
EMBO Member (2009)
| spouse =
| partner =
| children =
| website = {{URL|https://briscoelab.org/james-briscoe/}}
}}
James Briscoe is a British scientist who is a senior group leader at the Francis Crick Institute in London{{cite journal|last1=Brown|first1=Katherine|title=An interview with James Briscoe|journal=Development|volume=145|issue=6|year=2018|pages=dev165274|issn=0950-1991|doi=10.1242/dev.165274|pmid= 29588292|doi-access=free}} and editor-in-chief of the journal Development.
Education
Briscoe was educated at the University of Warwick and King's College London where he was awarded a PhD in 1996 for research on Janus kinases (JAKS), Signal Transducers and Activators of Transcriptions (STATs) and signal transduction in response to the interferons and Interleukin-6{{cite thesis|degree=PhD|publisher=King's College London (University of London)|url=https://discover.libraryhub.jisc.ac.uk/search?author=james%20briscoe&document-type=thesis&rn=1|title=JAKs, STATs and signal transduction in response to the interferons and interleukin-6|first= James|last=Briscoe|date=1996|id={{EThOS|uk.bl.ethos.336443}}|website=jisc.ac.uk|oclc=940139742}} supervised by Ian M. Kerr.{{cite web|title=Dr James Briscoe|archiveurl=https://web.archive.org/web/20190424061526/https://royalsociety.org/people/james-briscoe-14081/|archivedate=2019-04-24|url=https://royalsociety.org/people/james-briscoe-14081/|website=royalsociety.org|publisher=Royal Society|location=London|author=Anon|year=2019}} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{blockquote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{Webarchive|url=https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/|title=Royal Society Terms, conditions and policies|date=2016-11-11}}}}
Research and career
Briscoe was a postdoctoral researcher at Columbia University with Thomas Jessell.{{Cite journal|last1=Briscoe|first1=James|last2=Arber|first2=Silvia|date=2019|title=Thomas M. Jessell (1951–2019)|journal=Development|language=en|volume=146|issue=10|doi=10.1242/dev.180505|issn=0950-1991|pmid=31126924|doi-access=free}} In 2000 he moved to the National Institute for Medical Research to establish his own research group and in 2001 he was elected an EMBO Young Investigator.
His research interests include the molecular and cellular mechanisms of embryonic development with a particular focus on the developing spinal cord with a particular interest in how sonic hedgehog gradients and the hedgehog signaling pathway{{cite journal|last1=Briscoe|first1=James|last2=Thérond|first2=Pascal P.|title=The mechanisms of Hedgehog signalling and its roles in development and disease|journal=Nature Reviews Molecular Cell Biology|volume=14|issue=7|year=2013|pages=416–429|issn=1471-0072|doi=10.1038/nrm3598|pmid= 23719536|s2cid=25137907 }} regulate the development of this tissue.{{cite journal|last1=Briscoe|first1=James|last2=Pierani|first2=Alessandra|last3=Jessell|first3=Thomas M|last4=Ericson|first4=Johan|title=A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube|journal=Cell|volume=101|issue=4|year=2000|pages=435–445|issn=0092-8674|doi=10.1016/S0092-8674(00)80853-3|pmid= 10830170|doi-access=free}}{{cite journal|last1=Ericson|first1=J|last2=Rashbass|first2=P|last3=Schedl|first3=A|last4=Brenner-Morton|first4=S|last5=Kawakami|first5=A|last6=van Heyningen|first6=V|last7=Jessell|first7=T.M|last8=Briscoe|first8=J|title=Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling|journal=Cell|volume=90|issue=1|year=1997|pages=169–180|issn=0092-8674|doi=10.1016/S0092-8674(00)80323-2|pmid= 9230312|doi-access=free}} To address these questions, he uses a range of experimental biology and computational biology techniques with model systems that include laboratory mouse and chick embryos as well as embryonic stem cells.
=Awards and honours=
Briscoe was awarded the EMBO Gold Medal in 2008 and elected a member of the European Molecular Biology Organization (EMBO) in 2009. In 2018 he became editor-in-chief of the journal Development. He was elected a Fellow of the Royal Society (FRS) in 2019 and is a Fellow of the Academy of Medical Sciences (FMedSci).
References
{{reflist}}
{{FRS 2019}}
{{Authority control}}
{{DEFAULTSORT:Briscoe, James}}
Category:Alumni of King's College London
Category:Alumni of the University of Warwick
Category:Fellows of the Royal Society
Category:Fellows of the Academy of Medical Sciences (United Kingdom)