Jason Sheltzer

Sheltzer received a BA in molecular biology from Princeton University and a PhD in biology from the Massachusetts Institute of Technology.{{Cite web|last=Austin|first=Jim|date=2014-07-08|title=A Young Tag Team Detects a Major Pipeline Leak|url=https://www.science.org/content/article/young-tag-team-detects-major-pipeline-leak|access-date=2020-06-06|website=Science {{!}} AAAS|language=en}}{{Cite web|title=AACR-Bayer Innovation and Discovery Grants {{!}} American Association for Cancer Research|url=https://www.aacr.org/professionals/research-funding/independent-investigator-grant-recipients/aacr-bayer-innovation-and-discovery-grants/|access-date=2020-06-06|website=American Association for Cancer Research (AACR)|language=en}} At MIT, Sheltzer performed his PhD research with Angelika Amon on the consequences of aneuploidy.{{Cite web|date=2016-10-06|title=McKinley and Sheltzer to Receive 2016 Bernfield and Gilula Awards|url=https://www.ascb.org/member-news/mckinley-sheltzer-receive-2016-bernfield-gilula-awards/|access-date=2020-06-06|website=ASCB|language=en-US}} Sheltzer then established his own research group as an independent fellow at Cold Spring Harbor Laboratory.{{Cite web|last=Ricks|first=Delthia|date=2018-12-25|title=Researcher aims to take uncertainty out of cancer diagnosis|url=https://www.newsday.com/news/health/cancer-gene-cold-spring-harbor-1.24781725|access-date=2020-06-06|website=Newsday|language=en}} In 2021 Sheltzer was recruited to move his lab to Yale University.{{Cite web|last=Smith|first=Cecelia|title=Geneticist and Diversity Champion Jason Sheltzer Brings Award-Winning Research Lab to Yale Surgery|url=https://medicine.yale.edu/news-article/geneticist-jason-sheltzer-brings-award-winning-lab-to-yale/|access-date=2021-12-26|website=medicine.yale.edu|language=en}}

Sheltzer uses CRISPR/Cas9 technology to study aneuploidy and cancer genomics.{{Cite web|date=2018-09-20|title=Fox 5 (New York): Modifying Cancer Cell Genomes [The Big Idea]|website=YouTube |url=https://www.youtube.com/watch?v=xypH32pDcV8}}{{Cite web|last=Kaiser|first=Jocelyn|date=2019-09-11|title=Some cancer drugs miss their target. CRISPR could improve their aim|url=https://www.science.org/content/article/some-cancer-drugs-miss-their-target-crispr-could-improve-their-aim|access-date=2020-06-20|website=Science {{!}} AAAS|language=en}} Through the use of chromosome engineering, he has constructed cancer cells with different degrees of aneuploidy, and he has found how aneuploidy affects tumor development and metastasis.{{Cite journal|last=Seton-Rogers|first=Sarah|s2cid=41054562|date=March 2017|title=Fitness penalties of aneuploidy|url=https://www.nature.com/articles/nrc.2017.9|journal=Nature Reviews Cancer|language=en|volume=17|issue=3|pages=142–143|doi=10.1038/nrc.2017.9|pmid=28184042|issn=1474-1768|url-access=subscription}}{{Cite journal|last=Seton-Rogers|first=Sarah|s2cid=214718880|date=2020-03-31|title=Weighing up effects of extra chromosomes|journal=Nature Reviews Cancer|language=en|volume=20|issue=5|pages=259|doi=10.1038/s41568-020-0257-y|pmid=32235903|issn=1474-175X|doi-access=free}}{{Cite news |last=Johnson |first=Carolyn Y. |date=2023-07-06 |title=Gene editing helped crack a 100-year-old mystery about cancer |language=en-US |newspaper=Washington Post |url=https://www.washingtonpost.com/science/2023/07/06/cancer-cells-extra-chromosomes/ |access-date=2023-07-16 |issn=0190-8286}} In 2019, he discovered a set of copy number alteration biomarkers that can be used to predict cancer patient outcomes.{{Cite web|last=Thomas|first=Uduak Grace|date=2018-12-18|title=Cancer Genetic Studies Explore Prognostic Value of Copy Number Alterations, Other Biomarkers|url=https://www.genomeweb.com/cancer/cancer-genetic-studies-explore-prognostic-value-copy-number-alterations-other-biomarkers|access-date=2020-06-06|website=GenomeWeb|language=en-us}}{{Cite web|last=Dunaief|first=Daniel|title=CSHL's Jason Sheltzer and Google's Joan Smith team up in cancer study {{!}} TBR News Media|url=https://tbrnewsmedia.com/cshls-jason-sheltzer-and-googles-joan-smith-team-up-in-cancer-study/|access-date=2020-06-20|language=en-US}} His research has questioned whether anti-cancer drugs could be acting through alternate mechanisms.{{Cite news|last=Zimmer|first=Carl|date=2019-09-11|title=Why Aren't Cancer Drugs Better? The Targets Might Be Wrong|language=en-US|work=The New York Times|url=https://www.nytimes.com/2019/09/11/health/cancer-drugs-proteins.html|access-date=2020-06-06|issn=0362-4331}}{{Cite web|last=Belluz|first=Julia|date=2019-09-16|title=Most cancer drugs fail in testing. This might be a big reason why.|url=https://www.vox.com/2019/9/16/20864066/cancer-studies-fail|access-date=2020-06-06|website=Vox|language=en}}{{Cite web|last=Preidt|first=Robert|date=2019-09-11|title=Cancer Drugs Sometimes Work in Unexpected Ways: Study|url=https://www.usnews.com/news/health-news/articles/2019-09-11/cancer-drugs-sometimes-work-in-unexpected-ways-study|website=U.S. News & World Report}} He is a co-founder of Meliora Therapeutics.{{Cite web |last=Gormley |first=Brian |title=Biotech Meliora Therapeutics Gets $11 Million Seed Financing for Cancer Treatments |url=https://www.wsj.com/articles/biotech-meliora-therapeutics-gets-11-million-seed-financing-for-cancer-treatments-11664445603 |access-date=2023-07-16 |website=WSJ |language=en-US}}

Sheltzer also studies gender disparities in biology research. He discovered that some faculty members, like Nobel Prize winners, tended to hire very few female students in their labs, which could contribute to the gender gap in STEM.{{Cite news|last=McGregor|first=Jenna|date=2014-07-17|title=Study: Top labs run by men tend to hire fewer women|newspaper=The Washington Post|url=https://www.washingtonpost.com/news/on-leadership/wp/2014/07/17/study-top-labs-run-by-men-tend-to-hire-fewer-women/}}{{Cite magazine|last=Dockterman|first=Eliana|date=2014-07-09|title=Study: Male Scientists Employ Fewer Women in Labs|url=https://time.com/2969814/women-male-scientists/|access-date=2020-06-06|magazine=Time|language=en}}{{Cite web|last=Hu|first=Jane C.|date=2014-06-30|title=Male Professors Rarely Train Female Scientists|url=https://slate.com/human-interest/2014/06/women-in-science-a-new-study-on-how-male-professors-discriminate-against-women-in-scientific-labs.html|access-date=2020-06-06|website=Slate Magazine|language=en}}

• Forbes Magazine, 30 under 30 in Science{{Cite web|title=Jason Sheltzer, 28|url=https://www.forbes.com/pictures/ggik45ekh/jason-sheltzer-28/|access-date=2020-06-06|website=Forbes|language=en}}
• American Society for Cell Biology, Gilula Prize{{Cite web|date=2016-11-07|title=McKinley and Sheltzer to Receive 2016 Bernfield and Gilula Awards|url=https://www.ascb.org/member-news/mckinley-sheltzer-receive-2016-bernfield-gilula-awards-november-december-2016-newsletter/|access-date=2020-09-17|website=ASCB|language=en-US}}
• White House Office of Science and Technology, Presidential Early-Career Science and Engineering Award{{Cite web|title=President Donald J. Trump Announces Recipients of the Presidential Early Career Award for Scientists and Engineers|url=https://trumpwhitehouse.archives.gov/briefings-statements/president-donald-j-trump-announces-recipients-presidential-early-career-award-scientists-engineers/|access-date=2020-06-06|via=National Archives|work=whitehouse.gov|language=en-US}}

{{reflist}}

{{authority control}}

{{DEFAULTSORT:Sheltzer, Jason}}

Category:Cancer researchers

Category:Year of birth missing (living people)

Category:Living people

Category:21st-century American biologists

Category:Massachusetts Institute of Technology School of Science alumni

Category:Princeton University alumni

Category:Recipients of the Presidential Early Career Award for Scientists and Engineers