Jeffrey Siewerdsen
{{Infobox scientist
| name = Jeffrey H. Siewerdsen
| image =
| image_size =
| alt =
| caption = Jeffrey Siewerdsen in 2014.
| birth_date = {{Birth year and age|1969}}
| birth_place =
| death_date =
| death_place =
| residence =
| citizenship =
| nationality =
| fields =
| workplaces = Johns Hopkins University
University of Toronto
William Beaumont Hospital
University of Michigan
University of Minnesota
| alma_mater = University of Michigan
University of Minnesota
| thesis_title = Signal, Noise, and Detective Quantum Efficiency of a-Si:H Flat-Panel Imagers
| thesis_url = https://deepblue.lib.umich.edu/handle/2027.42/131326
| thesis_year = 1998
| doctoral_advisor = Larry E. Antonuk
| academic_advisors =
| known_for = Image-guided surgery
| author_abbrev_bot =
| author_abbrev_zoo =
| influences =
| influenced =
| awards = Moses and Sylvia Greenfield Award (2015)
Sylvia Fedoruk Award (2005)
Farrington-Daniels Award (2002)
Sylvia Sorkin Greenfield Award (2001)
| signature =
| signature_alt =
| website = [http://istar.jhu.edu The I-STAR Lab]
[http://carnegie.jhu.edu The Carnegie Center for Surgical Innovation]
| footnotes =
| spouse =
}}
Jeffrey Harold Siewerdsen (born 1969) is an American physicist and biomedical engineer who is a Professor of Imaging Physics at The University of Texas MD Anderson Cancer Center as well as Biomedical Engineering, Computer Science, Radiology, and Neurosurgery at Johns Hopkins University.He is among the original inventors of cone-beam CT-guided radiotherapy{{Cite journal|last1=Jaffray|first1=David A|last2=Siewerdsen|first2=Jeffrey H|last3=Wong|first3=John W|last4=Martinez|first4=Alvaro A|title=Flat-panel cone-beam computed tomography for image-guided radiation therapy|journal=International Journal of Radiation Oncology, Biology, Physics|volume=53|issue=5|pages=1337–1349|doi=10.1016/s0360-3016(02)02884-5|pmid=12128137|year=2002}} as well as weight-bearing cone-beam CT{{Cite journal|last1=Zbijewski|first1=W.|last2=De Jean|first2=P.|last3=Prakash|first3=P.|last4=Ding|first4=Y.|last5=Stayman|first5=J. W.|last6=Packard|first6=N.|last7=Senn|first7=R.|last8=Yang|first8=D.|last9=Yorkston|first9=J.|date=2011-08-01|title=A dedicated cone-beam CT system for musculoskeletal extremities imaging: Design, optimization, and initial performance characterization|journal=Medical Physics|language=en|volume=38|issue=8|pages=4700–4713|doi=10.1118/1.3611039|pmid=21928644|issn=2473-4209|pmc=3172864|bibcode=2011MedPh..38.4700Z}}{{Cite journal|last1=Carrino|first1=John A.|last2=Al Muhit|first2=Abdullah|last3=Zbijewski|first3=Wojciech|last4=Thawait|first4=Gaurav K.|last5=Stayman|first5=J. Webster|last6=Packard|first6=Nathan|last7=Senn|first7=Robert|last8=Yang|first8=Dong|last9=Foos|first9=David H.|date=2013-11-18|title=Dedicated Cone-Beam CT System for Extremity Imaging|journal=Radiology|volume=270|issue=3|pages=816–824|doi=10.1148/radiol.13130225|pmid=24475803|issn=0033-8419|pmc=4263642}} for musculoskeletal radiology and orthopedic surgery. His work also includes the early development of flat-panel detectors on mobile C-arms for intraoperative cone-beam CT in image-guided surgery.{{Cite journal|last1=Siewerdsen|first1=J. H.|last2=Moseley|first2=D. J.|last3=Burch|first3=S.|last4=Bisland|first4=S. K.|last5=Bogaards|first5=A.|last6=Wilson|first6=B. C.|last7=Jaffray|first7=D. A.|date=2005-01-01|title=Volume CT with a flat-panel detector on a mobile, isocentric C-arm: Pre-clinical investigation in guidance of minimally invasive surgery|journal=Medical Physics|language=en|volume=32|issue=1|pages=241–254|doi=10.1118/1.1836331|pmid=15719975|bibcode=2005MedPh..32..241S|issn=2473-4209}} He developed early models for the signal and noise performance of flat-panel detectors{{Cite journal|last1=Siewerdsen|first1=J. H.|last2=Antonuk|first2=L. E.|last3=El-Mohri|first3=Y.|last4=Yorkston|first4=J.|last5=Huang|first5=W.|last6=Cunningham|first6=I. A.|date=1998-05-01|title=Signal, noise power spectrum, and detective quantum efficiency of indirect-detection flat-panel imagers for diagnostic radiology|journal=Medical Physics|language=en|volume=25|issue=5|pages=614–628|doi=10.1118/1.598243|pmid=9608470|bibcode=1998MedPh..25..614S|s2cid=22972871|issn=2473-4209|hdl=2027.42/135120|hdl-access=free}} and later extended such analysis to dual-energy imaging{{Cite journal|last1=Richard|first1=S.|last2=Siewerdsen|first2=J. H.|last3=Jaffray|first3=D. A.|last4=Moseley|first4=D. J.|last5=Bakhtiar|first5=B.|date=2005-05-01|title=Generalized DQE analysis of radiographic and dual-energy imaging using flat-panel detectors|journal=Medical Physics|language=en|volume=32|issue=5|pages=1397–1413|doi=10.1118/1.1901203|pmid=15984691|bibcode=2005MedPh..32.1397R|s2cid=25037074|issn=2473-4209}} and 3D imaging performance in cone-beam CT.{{Cite journal|last1=Tward|first1=Daniel J.|last2=Siewerdsen|first2=Jeffrey H.|date=2008-12-01|title=Cascaded systems analysis of the 3D noise transfer characteristics of flat-panel cone-beam CT|journal=Medical Physics|language=en|volume=35|issue=12|pages=5510–5529|doi=10.1118/1.3002414|pmid=19175110|pmc=2673616|bibcode=2008MedPh..35.5510T|issn=2473-4209}} He founded the ISTAR Lab (Imaging for Surgery, Therapy, and Radiology) in the Department of Biomedical Engineering, the Carnegie Center for Surgical Innovation at Johns Hopkins Hospital, and the Surgical Data Science Program at the Institute for Data Science in Oncology at The University of Texas MD Anderson Cancer Center.
Biography and scientific work
Jeffrey Siewerdsen did his undergraduate studies at the University of Minnesota in Minneapolis, MN, where he received his Bachelor of Arts degree in Physics and Astrophysics with a minor in Japanese in 1992. His undergraduate research experience included construction and testing of particle detectors for the Soudan 2 proton decay project.
Siewerdsen began graduate studies at the University of Michigan in Ann Arbor, MI, in 1992, working initially in high-energy physics (D0 experiment) under supervision of Professor Homer Neal and earning his Master of Science degree in Physics in 1994.
Siewerdsen's doctoral research involved early development of amorphous silicon Flat panel detector for medical x-ray imaging under the supervision of Professor Larry E. Antonuk. Siewerdsen's work focused on the development of early flat-panel detector systems for diagnostic radiography, fluoroscopy, and mammography as well as megavoltage portal imaging for guidance of radiation therapy. His doctoral dissertation{{Cite journal|last=Siewerdsen|first=Jeffrey H.|date=1998-11-01|title=Signal, noise, and detective quantum efficiency of a-Si:H flat-panel imagers|journal=Medical Physics|language=en|volume=25|issue=11|pages=2250|doi=10.1118/1.598427|bibcode=1998MedPh..25.2250S|issn=2473-4209|hdl=2027.42/135065|url=https://deepblue.lib.umich.edu/bitstream/2027.42/135065/1/mp8427.pdf|hdl-access=free}} established mathematical models for the signal-to-noise properties (specifically, the modulation transfer function, noise-power spectrum, and detective quantum efficiency) of flat-panel x-ray detectors. His Ph.D. thesis was awarded the Kent M. Terwilliger Prize for Best Doctoral Dissertation in Physics, 1998.
Siewerdsen conducted post-graduate research beginning in 1998 as a research scientist at William Beaumont Hospital in Royal Oak, MI, with Dr. David Jaffray and Dr. John Wong on the topic of cone beam computed tomography (CBCT) for image-guided radiation therapy (IGRT).{{Cite journal|last1=Jaffray|first1=David A|last2=Siewerdsen|first2=Jeffrey H|last3=Wong|first3=John W|last4=Martinez|first4=Alvaro A|title=Flat-panel cone-beam computed tomography for image-guided radiation therapy|journal=International Journal of Radiation Oncology, Biology, Physics|volume=53|issue=5|pages=1337–1349|doi=10.1016/s0360-3016(02)02884-5|pmid=12128137|year=2002}}{{Cite journal|last1=Jaffray|first1=D. A.|last2=Siewerdsen|first2=J. H.|date=2000-06-01|title=Cone-beam computed tomography with a flat-panel imager: Initial performance characterization|journal=Medical Physics|language=en|volume=27|issue=6|pages=1311–1323|doi=10.1118/1.599009|pmid=10902561|bibcode=2000MedPh..27.1311J|s2cid=5912142|issn=2473-4209|doi-access=free}} The Beaumont team produced the first IGRT system for CBCT, beginning with laboratory studies to investigate image quality characteristics,{{Cite journal|last1=Siewerdsen|first1=Jeffrey H.|last2=Jaffray|first2=David A.|date=2001-02-01|title=Cone-beam computed tomography with a flat-panel imager: Magnitude and effects of x-ray scatter|journal=Medical Physics|language=en|volume=28|issue=2|pages=220–231|doi=10.1118/1.1339879|pmid=11243347|bibcode=2001MedPh..28..220S|s2cid=36436056|issn=2473-4209|doi-access=free}} and translating to clinical studies for guidance of prostate cancer therapy.{{Cite journal|last1=Létourneau|first1=Daniel|last2=Wong|first2=John W.|last3=Oldham|first3=Mark|last4=Gulam|first4=Misbah|last5=Watt|first5=Lindsay|last6=Jaffray|first6=David A.|last7=Siewerdsen|first7=Jeffrey H.|last8=Martinez|first8=Alvaro A.|title=Cone-beam-CT guided radiation therapy: technical implementation|journal=Radiotherapy and Oncology|volume=75|issue=3|pages=279–286|doi=10.1016/j.radonc.2005.03.001|pmid=15890424|year=2005}}
Siewerdsen joined the Ontario Cancer Institute and University of Toronto Department of Medical Biophysics as a scientist and assistant professor, respectively, in 2002, and subsequently as senior scientist and associate professor in 2007. Research in his laboratory focused on image-guided surgery, new imaging methods such as dual-energy imaging, and image registration. His work involved the development of early systems for cone beam computed tomography (CBCT) with a flat-panel detector on mobile C-arms for image-guided surgery{{Cite journal|last1=Siewerdsen|first1=J. H.|last2=Moseley|first2=D. J.|last3=Burch|first3=S.|last4=Bisland|first4=S. K.|last5=Bogaards|first5=A.|last6=Wilson|first6=B. C.|last7=Jaffray|first7=D. A.|date=2005-01-01|title=Volume CT with a flat-panel detector on a mobile, isocentric C-arm: Pre-clinical investigation in guidance of minimally invasive surgery|journal=Medical Physics|language=en|volume=32|issue=1|pages=241–254|doi=10.1118/1.1836331|pmid=15719975|bibcode=2005MedPh..32..241S|issn=2473-4209}} and translated the first such systems to clinical studies in image-guided Otolaryngology–Head and Neck Surgery{{Cite journal|last1=Daly|first1=M. J.|last2=Siewerdsen|first2=J. H.|last3=Moseley|first3=D. J.|last4=Jaffray|first4=D. A.|last5=Irish|first5=J. C.|date=2006-10-01|title=Intraoperative cone-beam CT for guidance of head and neck surgery: Assessment of dose and image quality using a C-arm prototype|journal=Medical Physics|language=en|volume=33|issue=10|pages=3767–3780|doi=10.1118/1.2349687|pmid=17089842|bibcode=2006MedPh..33.3767D|issn=2473-4209}}{{Cite journal|last1=Rafferty|first1=M A.|last2=Siewerdsen|first2=J H.|last3=Chan|first3=Y|last4=Moseley|first4=D J.|last5=Daly|first5=M J.|last6=Jaffray|first6=D A.|last7=Irish|first7=J C.|date=2005-12-01|title=Investigation of C-Arm Cone-Beam CT-Guided Surgery of the Frontal Recess|journal=The Laryngoscope|language=en|volume=115|issue=12|pages=2138–2143|doi=10.1097/01.mlg.0000180759.52082.45|pmid=16369157|s2cid=26176142|issn=1531-4995}}{{Cite journal|last1=Rafferty|first1=Mark A.|last2=Siewerdsen|first2=Jeffrey H.|last3=Chan|first3=Yvonne|last4=Daly|first4=Michael J.|last5=Moseley|first5=Douglas J.|last6=Jaffray|first6=David A.|last7=Irish|first7=Jonathan C.|date=2016-05-17|title=Intraoperative Cone-beam CT for Guidance of Temporal Bone Surgery|journal=Otolaryngology–Head and Neck Surgery|language=en|volume=134|issue=5|pages=801–808|doi=10.1016/j.otohns.2005.12.007|pmid=16647538|s2cid=30246312}} with Dr. Jonathan Irish. He also collaborated closely with Dr. Kristy Brock on deformable image registration using the Demons algorithm{{Cite journal|last1=Nithiananthan|first1=S.|last2=Brock|first2=K. K.|last3=Daly|first3=M. J.|last4=Chan|first4=H.|last5=Irish|first5=J. C.|last6=Siewerdsen|first6=J. H.|date=2009-10-01|title=Demons deformable registration for CBCT-guided procedures in the head and neck: Convergence and accuracy|journal=Medical Physics|language=en|volume=36|issue=10|pages=4755–4764|doi=10.1118/1.3223631|pmid=19928106|pmc=2771717|bibcode=2009MedPh..36.4755N|issn=2473-4209}}{{Cite journal|last1=Nithiananthan|first1=Sajendra|last2=Schafer|first2=Sebastian|last3=Mirota|first3=Daniel J.|last4=Stayman|first4=J. Webster|last5=Zbijewski|first5=Wojciech|last6=Reh|first6=Douglas D.|last7=Gallia|first7=Gary L.|last8=Siewerdsen|first8=Jeffrey H.|date=2012-09-01|title=Extra-dimensional Demons: A method for incorporating missing tissue in deformable image registration|journal=Medical Physics|language=en|volume=39|issue=9|pages=5718–5731|doi=10.1118/1.4747270|pmid=22957637|pmc=3443194|bibcode=2012MedPh..39.5718N|issn=2473-4209}} and with Dr. Narinder Paul on development of dual-energy chest radiography systems for detection of early stage lung cancer.{{Cite journal|last1=Shkumat|first1=N. A.|last2=Siewerdsen|first2=J. H.|last3=Dhanantwari|first3=A. C.|last4=Williams|first4=D. B.|last5=Richard|first5=S.|last6=Paul|first6=N. S.|last7=Yorkston|first7=J.|last8=Van Metter|first8=R.|date=2007-10-01|title=Optimization of image acquisition techniques for dual-energy imaging of the chest|journal=Medical Physics|language=en|volume=34|issue=10|pages=3904–3915|doi=10.1118/1.2777278|pmid=17985636|bibcode=2007MedPh..34.3904S|s2cid=43923656|issn=2473-4209}}{{Cite journal|last1=Kashani|first1=Hany|last2=Varon|first2=Carlos A.|last3=Paul|first3=Narinder S.|last4=Gang|first4=Grace J.|last5=Metter|first5=Rich Van|last6=Yorkston|first6=John|last7=Siewerdsen|first7=Jeffrey H.|title=Diagnostic Performance of a Prototype Dual-Energy Chest Imaging System|journal=Academic Radiology|volume=17|issue=3|pages=298–308|doi=10.1016/j.acra.2009.10.012|pmid=20042351|date=March 2010|hdl=1807/27355|url=https://tspace.library.utoronto.ca/bitstream/1807/27355/1/MehdizadehKashani_Hany_201103_MSc_thesis.pdf|hdl-access=free}}
His research also extended cascaded systems models{{Cite journal|last1=Siewerdsen|first1=J. H.|last2=Antonuk|first2=L. E.|last3=El-Mohri|first3=Y.|last4=Yorkston|first4=J.|last5=Huang|first5=W.|last6=Boudry|first6=J. M.|last7=Cunningham|first7=I. A.|date=1997-01-01|title=Empirical and theoretical investigation of the noise performance of indirect detection, active matrix flat-panel imagers (AMFPIs) for diagnostic radiology|journal=Medical Physics|language=en|volume=24|issue=1|pages=71–89|doi=10.1118/1.597919|pmid=9029542|bibcode=1997MedPh..24...71S|s2cid=37365180|issn=2473-4209|hdl=2027.42/134855|hdl-access=free}} for x-ray imaging performance to describe 3D imaging performance in CBCT{{Cite journal|last1=Tward|first1=Daniel J.|last2=Siewerdsen|first2=Jeffrey H.|date=2008-12-01|title=Cascaded systems analysis of the 3D noise transfer characteristics of flat-panel cone-beam CT|journal=Medical Physics|language=en|volume=35|issue=12|pages=5510–5529|doi=10.1118/1.3002414|pmid=19175110|pmc=2673616|bibcode=2008MedPh..35.5510T|issn=2473-4209}}{{Cite journal|last1=Tward|first1=Daniel J.|last2=Siewerdsen|first2=Jeffrey H.|date=2009-08-01|title=Noise aliasing and the 3D NEQ of flat-panel cone-beam CT: Effect of 2D/3D apertures and sampling|journal=Medical Physics|language=en|volume=36|issue=8|pages=3830–3843|doi=10.1118/1.3166933|pmid=19746816|pmc=2755461|bibcode=2009MedPh..36.3830T|issn=2473-4209}} and helped to establish mathematical methods for imaging system optimization according to the imaging task.{{Cite journal|last1=Gang|first1=Grace J.|last2=Lee|first2=Junghoon|last3=Stayman|first3=J. Webster|last4=Tward|first4=Daniel J.|last5=Zbijewski|first5=W.|last6=Prince|first6=Jerry L.|last7=Siewerdsen|first7=Jeffrey H.|date=2011-04-01|title=Analysis of Fourier-domain task-based detectability index in tomosynthesis and cone-beam CT in relation to human observer performance|journal=Medical Physics|language=en|volume=38|issue=4|pages=1754–1768|doi=10.1118/1.3560428|pmid=21626910|pmc=3069989|bibcode=2011MedPh..38.1754G|issn=2473-4209}} Siewerdsen joined Johns Hopkins Biomedical Engineering as an associate professor in 2009 and subsequently as a professor in 2012, with cross-appointment in Computer Science, Radiology, and Neurosurgery. He founded the [http://istar.jhu.edu I-STAR Lab] (Imaging for Surgery, Therapy, and Radiology) {{Cite web|url=http://istar.jhu.edu/|title=I-STAR Lab {{!}} Imaging for Surgery, Therapy, and Radiology|website=istar.jhu.edu|language=en-US|access-date=2017-11-13}} as a collaborative research endeavor bridging biomedical engineering with clinical collaborators at Johns Hopkins Hospital. In 2015, he established the [http://carnegie.jhu.edu Carnegie Center for Surgical Innovation] in the Johns Hopkins School of Medicine. He was also a John C. Malone Professor in Computer Science and Member of the Malone Center for Engineering in Healthcare. Research in Siewerdsen's laboratory includes: mathematical modeling / imaging science of digital x-ray,{{Cite journal|last=Siewerdsen|first=Jeffrey H.|title=Cone-beam CT with a flat-panel detector: From image science to image-guided surgery|journal=Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment|volume=648|issue=S1|pages=S241–S250|doi=10.1016/j.nima.2010.11.088|pmid=22942510|pmc=3429946|year=2011|bibcode=2011NIMPA.648S.241S}} dual-energy imaging,{{Cite journal|last1=Richard|first1=S.|last2=Siewerdsen|first2=J. H.|date=2007-01-01|title=Optimization of dual-energy imaging systems using generalized NEQ and imaging task|journal=Medical Physics|language=en|volume=34|issue=1|pages=127–139|doi=10.1118/1.2400620|pmid=17278498|bibcode=2007MedPh..34..127R|issn=2473-4209}} cone beam computed tomography (CBCT),{{Cite journal|last1=Siewerdsen|first1=Jeffrey H.|last2=Jaffray|first2=David A.|date=2000-08-01|title=Optimization of x-ray imaging geometry (with specific application to flat-panel cone-beam computed tomography)|journal=Medical Physics|language=en|volume=27|issue=8|pages=1903–1914|doi=10.1118/1.1286590|pmid=10984236|bibcode=2000MedPh..27.1903S|issn=2473-4209}} and computed tomography (CT) systems;{{Cite journal|last1=Bian|first1=Junguo|last2=Siewerdsen|first2=Jeffrey H.|last3=Han|first3=Xiao|last4=Sidky|first4=Emil Y.|last5=Prince|first5=Jerry L.|last6=Pelizzari|first6=Charles A.|last7=Xiaochuan Pan|date=2010|title=Evaluation of sparse-view reconstruction from flat-panel-detector cone-beam CT|journal=Physics in Medicine and Biology|language=en|volume=55|issue=22|pages=6575–99|doi=10.1088/0031-9155/55/22/001|pmid=20962368|pmc=3597413|bibcode=2010PMB....55.6575B|issn=0031-9155}} image-guided surgery;{{Cite journal|last1=Schafer|first1=S.|last2=Nithiananthan|first2=S.|last3=Mirota|first3=D. J.|last4=Uneri|first4=A.|last5=Stayman|first5=J. W.|last6=Zbijewski|first6=W.|last7=Schmidgunst|first7=C.|last8=Kleinszig|first8=G.|last9=Khanna|first9=A. J.|date=2011-08-01|title=Mobile C-arm cone-beam CT for guidance of spine surgery: Image quality, radiation dose, and integration with interventional guidance|journal=Medical Physics|language=en|volume=38|issue=8|pages=4563–4574|doi=10.1118/1.3597566|pmid=21928628|pmc=3161502|bibcode=2011MedPh..38.4563S|issn=2473-4209}}{{Cite journal|last1=Wang|first1=Adam S|last2=Stayman|first2=J Webster|last3=Otake|first3=Yoshito|last4=Kleinszig|first4=Gerhard|last5=Vogt|first5=Sebastian|last6=Gallia|first6=Gary L|last7=Khanna|first7=A Jay|last8=Siewerdsen|first8=Jeffrey H|title=Soft-tissue imaging with C-arm cone-beam CT using statistical reconstruction|journal=Physics in Medicine and Biology|volume=59|issue=4|pages=1005–1026|doi=10.1088/0031-9155/59/4/1005|pmid=24504126|pmc=4046706|year=2014|bibcode=2014PMB....59.1005W}} multi-modality medical image registration;{{Cite journal|last1=Nithiananthan|first1=Sajendra|last2=Schafer|first2=Sebastian|last3=Uneri|first3=Ali|last4=Mirota|first4=Daniel J.|last5=Stayman|first5=J. Webster|last6=Zbijewski|first6=Wojciech|last7=Brock|first7=Kristy K.|last8=Daly|first8=Michael J.|last9=Chan|first9=Harley|date=2011-04-01|title=Demons deformable registration of CT and cone-beam CT using an iterative intensity matching approach|journal=Medical Physics|language=en|volume=38|issue=4|pages=1785–1798|doi=10.1118/1.3555037|pmid=21626913|pmc=3069990|bibcode=2011MedPh..38.1785N|issn=2473-4209}}{{Cite journal|last1=Reaungamornrat|first1=S|last2=Wang|first2=A S|last3=Uneri|first3=A|last4=Otake|first4=Y|last5=Khanna|first5=A J|last6=Siewerdsen|first6=J H|title=Deformable image registration with local rigidity constraints for cone-beam CT-guided spine surgery|journal=Physics in Medicine and Biology|volume=59|issue=14|pages=3761–3787|doi=10.1088/0031-9155/59/14/3761|pmid=24937093|pmc=4118832|year=2014|bibcode=2014PMB....59.3761R}}{{Cite journal|last1=Reaungamornrat|first1=S|last2=Silva|first2=T De|last3=Uneri|first3=A|last4=Goerres|first4=J|last5=Jacobson|first5=M|last6=Ketcha|first6=M|last7=Vogt|first7=S|last8=Kleinszig|first8=G|last9=Khanna|first9=A J|title=Performance evaluation of MIND demons deformable registration of MR and CT images in spinal interventions|journal=Physics in Medicine and Biology|volume=61|issue=23|pages=8276–8297|doi=10.1088/0031-9155/61/23/8276|pmid=27811396|pmc=5217769|year=2016|bibcode=2016PMB....61.8276R}}{{Cite journal|last1=Uneri|first1=Ali|last2=Nithiananthan|first2=Sajendra|last3=Schafer|first3=Sebastian|last4=Otake|first4=Yoshito|last5=Stayman|first5=J. Webster|last6=Kleinszig|first6=Gerhard|last7=Sussman|first7=Marc S.|last8=Prince|first8=Jerry L.|last9=Siewerdsen|first9=Jeffrey H.|date=2013-01-01|title=Deformable registration of the inflated and deflated lung in cone-beam CT-guided thoracic surgery: Initial investigation of a combined model- and image-driven approach|journal=Medical Physics|language=en|volume=40|issue=1|page=017501|doi=10.1118/1.4767757|pmid=23298134|pmc=3537709|bibcode=2013MedPh..40a7501U|issn=2473-4209}} new imaging systems for musculoskeletal radiology and orthopedic surgery;{{Cite journal|last1=Prakash|first1=P.|last2=Zbijewski|first2=W.|last3=Gang|first3=G. J.|last4=Ding|first4=Y.|last5=Stayman|first5=J. W.|last6=Yorkston|first6=J.|last7=Carrino|first7=J. A.|last8=Siewerdsen|first8=J. H.|date=2011-10-01|title=Task-based modeling and optimization of a cone-beam CT scanner for musculoskeletal imaging|journal=Medical Physics|language=en|volume=38|issue=10|pages=5612–5629|doi=10.1118/1.3633937|pmid=21992379|pmc=3208412|bibcode=2011MedPh..38.5612P|issn=2473-4209}}{{Cite journal|last1=Carrino|first1=John A.|last2=Al Muhit|first2=Abdullah|last3=Zbijewski|first3=Wojciech|last4=Thawait|first4=Gaurav K.|last5=Stayman|first5=J. Webster|last6=Packard|first6=Nathan|last7=Senn|first7=Robert|last8=Yang|first8=Dong|last9=Foos|first9=David H.|date=2013-11-18|title=Dedicated Cone-Beam CT System for Extremity Imaging|journal=Radiology|volume=270|issue=3|pages=816–824|doi=10.1148/radiol.13130225|pmid=24475803|issn=0033-8419|pmc=4263642}} and clinical research collaborations in robot-assisted surgery and data science related to medical imaging.
In 2022, Siewerdsen joined The University of Texas MD Anderson Cancer as a Professor Imaging Physics, Radiation Physics, and Neurosurgery, where he directs the Surgical Data Science Program in the Institute for Data Science in Oncology.
Notable scientific contributions from Siewerdsen's work include:
- Cone beam computed tomography (CBCT) systems on mobile C-arms for image-guided surgery.{{Cite journal|last=Siewerdsen|first=Jeffrey H.|date=2011-08-21|title=Cone-Beam CT with a Flat-Panel Detector: From Image Science to Image-Guided Surgery|journal=Nuclear Instruments and Methods in Physics Research Section A|volume=648|issue=Suppl 1|pages=S241–S250|doi=10.1016/j.nima.2010.11.088|issn=0168-9002|pmc=3429946|pmid=22942510|bibcode=2011NIMPA.648S.241S}}{{Cite book|last1=Mirota|first1=Daniel J.|last2=Uneri|first2=Ali|last3=Schafer|first3=Sebastian|last4=Nithiananthan|first4=Sajendra|last5=Reh|first5=Douglas D.|last6=Gallia|first6=Gary L.|last7=Taylor|first7=Russell H.|last8=Hager|first8=Gregory D.|last9=Siewerdsen|first9=Jeffrey H.|editor1-first=Kenneth H|editor1-last=Wong|editor2-first=David R|editor2-last=Holmes Iii|date=2011-03-02|publisher=International Society for Optics and Photonics|volume=7964|pages=79640J|doi=10.1117/12.877803|title=Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling|chapter=High-accuracy 3D image-based registration of endoscopic video to C-arm cone-beam CT for image-guided skull base surgery|series=Proceedings of SPIE |pmid=37621998 |pmc=10448534 |s2cid=45754324}}
- Cone beam computed tomography (CBCT) systems for imaging of the weight-bearing foot, ankle, and knee with high spatial resolution and low radiation dose.{{Cite news|url=https://hub.jhu.edu/2016/10/27/jeff-siewerdsen-standing-ct-machine/|title=A stand-up CT machine: Weight-bearing scanner developed at Johns Hopkins wins industry accolade|date=2016-10-27|work=The Hub|access-date=2017-11-12|language=en}}
- Cone beam computed tomography (CBCT) systems for image-guided radiation therapy (IGRT).{{Cite journal|last1=Jaffray|first1=David A.|last2=Siewerdsen|first2=Jeffrey H.|last3=Wong|first3=John W.|last4=Martinez|first4=Alvaro A.|date=2002-08-01|title=Flat-panel cone-beam computed tomography for image-guided radiation therapy|journal=International Journal of Radiation Oncology, Biology, Physics|volume=53|issue=5|pages=1337–1349|issn=0360-3016|pmid=12128137|doi=10.1016/s0360-3016(02)02884-5}}
- Cone beam computed tomography (CBCT) systems for high-quality, low-dose imaging of intracranial hemorrhage.{{Cite journal|last1=Xu|first1=Jennifer|last2=Sisniega|first2=Alejandro|last3=Zbijewski|first3=Wojciech|last4=Dang|first4=Hao|last5=Stayman|first5=J. Webster|last6=Mow|first6=Michael|last7=Wang|first7=Xiaohui|last8=Foos|first8=David H.|last9=Koliatsos|first9=Vassillis E.|date=October 2016|title=Technical assessment of a prototype cone-beam CT system for imaging of acute intracranial hemorrhage|journal=Medical Physics|volume=43|issue=10|pages=5745|doi=10.1118/1.4963220|issn=2473-4209|pmid=27782694|bibcode=2016MedPh..43.5745X|doi-access=free}}
- Influence of x-ray Compton scattering in cone beam computed tomography (CBCT).{{Cite journal|last1=Siewerdsen|first1=Jeffrey H.|last2=Jaffray|first2=David A.|date=2001-02-01|title=Cone-beam computed tomography with a flat-panel imager: Magnitude and effects of x-ray scatter|journal=Medical Physics|language=en|volume=28|issue=2|pages=220–231|doi=10.1118/1.1339879|pmid=11243347|bibcode=2001MedPh..28..220S|s2cid=36436056|issn=2473-4209|doi-access=free}}
- Image registration methods for minimally invasive spine surgery.{{Cite journal|last1=Reaungamornrat|first1=S.|last2=Silva|first2=T. De|last3=Uneri|first3=A.|last4=Vogt|first4=S.|last5=Kleinszig|first5=G.|last6=Khanna|first6=A. J.|last7=Wolinsky|first7=J. P.|last8=Prince|first8=J. L.|last9=Siewerdsen|first9=J. H.|date=November 2016|title=MIND Demons: Symmetric Diffeomorphic Deformable Registration of MR and CT for Image-Guided Spine Surgery|journal=IEEE Transactions on Medical Imaging|volume=35|issue=11|pages=2413–2424|doi=10.1109/TMI.2016.2576360|pmid=27295656|pmc=5097014|issn=0278-0062}}{{Cite journal|last1=Otake|first1=Yoshito|last2=Wang|first2=Adam S|last3=Stayman|first3=J Webster|last4=Uneri|first4=Ali|last5=Kleinszig|first5=Gerhard|last6=Vogt|first6=Sebastian|last7=Khanna|first7=A Jay|last8=Gokaslan|first8=Ziya L|last9=Siewerdsen|first9=Jeffrey H|title=Robust 3D–2D image registration: application to spine interventions and vertebral labeling in the presence of anatomical deformation|journal=Physics in Medicine and Biology|volume=58|issue=23|pages=8535–8553|doi=10.1088/0031-9155/58/23/8535|pmid=24246386|pmc=4915373|year=2013|bibcode=2013PMB....58.8535O}}{{Cite journal|last1=Uneri|first1=A|last2=Silva|first2=T De|last3=Stayman|first3=J W|last4=Kleinszig|first4=G|last5=Vogt|first5=S|last6=Khanna|first6=A J|last7=Gokaslan|first7=Z L|last8=Wolinsky|first8=J-P|last9=Siewerdsen|first9=J H|title=Known-component 3D–2D registration for quality assurance of spine surgery pedicle screw placement|journal=Physics in Medicine and Biology|volume=60|issue=20|pages=8007–8024|doi=10.1088/0031-9155/60/20/8007|pmid=26421941|pmc=4640195|year=2015|bibcode=2015PMB....60.8007U}}
- Image registration methods for Otolaryngology–Head and Neck Surgery.{{Cite journal|last1=Nithiananthan|first1=Sajendra|last2=Schafer|first2=Sebastian|last3=Uneri|first3=Ali|last4=Mirota|first4=Daniel J.|last5=Stayman|first5=J. Webster|last6=Zbijewski|first6=Wojciech|last7=Brock|first7=Kristy K.|last8=Daly|first8=Michael J.|last9=Chan|first9=Harley|date=2011-04-01|title=Demons deformable registration of CT and cone-beam CT using an iterative intensity matching approach|journal=Medical Physics|language=en|volume=38|issue=4|pages=1785–1798|doi=10.1118/1.3555037|pmid=21626913|pmc=3069990|bibcode=2011MedPh..38.1785N|issn=2473-4209}}{{Cite journal|last1=Nithiananthan|first1=Sajendra|last2=Schafer|first2=Sebastian|last3=Mirota|first3=Daniel J.|last4=Stayman|first4=J. Webster|last5=Zbijewski|first5=Wojciech|last6=Reh|first6=Douglas D.|last7=Gallia|first7=Gary L.|last8=Siewerdsen|first8=Jeffrey H.|date=2012-09-01|title=Extra-dimensional Demons: A method for incorporating missing tissue in deformable image registration|journal=Medical Physics|language=en|volume=39|issue=9|pages=5718–5731|doi=10.1118/1.4747270|pmid=22957637|pmc=3443194|bibcode=2012MedPh..39.5718N|issn=2473-4209}}
- Mathematical models of 3D imaging performance in cone beam computed tomography (CBCT).{{Cite journal|last1=Gang|first1=G. J.|last2=Tward|first2=D. J.|last3=Lee|first3=J.|last4=Siewerdsen|first4=J. H.|date=2010-05-01|title=Anatomical background and generalized detectability in tomosynthesis and cone-beam CT|journal=Medical Physics|language=en|volume=37|issue=5|pages=1948–1965|doi=10.1118/1.3352586|pmid=20527529|pmc=2862054|bibcode=2010MedPh..37.1948G|issn=2473-4209}}{{Cite journal|last1=Tward|first1=Daniel J.|last2=Siewerdsen|first2=Jeffrey H.|date=2008-12-01|title=Cascaded systems analysis of the 3D noise transfer characteristics of flat-panel cone-beam CT|journal=Medical Physics|language=en|volume=35|issue=12|pages=5510–5529|doi=10.1118/1.3002414|pmid=19175110|pmc=2673616|bibcode=2008MedPh..35.5510T|issn=2473-4209}}
- Mathematical models of spectral and phase-contrast imaging performance for photon counting x-ray detectors.{{Cite journal|last1=Xu|first1=J.|last2=Zbijewski|first2=W.|last3=Gang|first3=G.|last4=Stayman|first4=J. W.|last5=Taguchi|first5=K.|last6=Lundqvist|first6=M.|last7=Fredenberg|first7=E.|last8=Carrino|first8=J. A.|last9=Siewerdsen|first9=J. H.|date=2014-10-01|title=Cascaded systems analysis of photon counting detectors|journal=Medical Physics|language=en|volume=41|issue=10|page=101907|doi=10.1118/1.4894733|pmid=25281959|pmc=4281040|bibcode=2014MedPh..41j1907X|issn=2473-4209}}{{Cite journal|last1=Fredenberg|first1=Erik|last2=Danielsson|first2=Mats|last3=Stayman|first3=J. Webster|last4=Siewerdsen|first4=Jeffrey H.|last5=Åslund|first5=Magnus|date=2012-08-10|title=Ideal-observer detectability in photon-counting differential phase-contrast imaging using a linear-systems approach: Ideal-observer detectability in differential phase-contrast imaging|journal=Medical Physics|language=en|volume=39|issue=9|pages=5317–5335|doi=10.1118/1.4739195|pmc=3427340|pmid=22957600|bibcode=2012MedPh..39.5317F }}
- Mathematical models of 2D imaging performance for flat-panel detectors.{{Cite journal|last=Siewerdsen|first=Jeffrey H.|date=1998-11-01|title=Signal, noise, and detective quantum efficiency of a-Si:H flat-panel imagers|journal=Medical Physics|language=en|volume=25|issue=11|pages=2250|doi=10.1118/1.598427|bibcode=1998MedPh..25.2250S|issn=2473-4209|hdl=2027.42/135065|url=https://deepblue.lib.umich.edu/bitstream/2027.42/135065/1/mp8427.pdf|hdl-access=free}}{{Cite journal|last1=Siewerdsen|first1=J. H.|last2=Cunningham|first2=I. A.|last3=Jaffray|first3=D. A.|date=2002-11-01|title=A framework for noise-power spectrum analysis of multidimensional images|journal=Medical Physics|language=en|volume=29|issue=11|pages=2655–2671|doi=10.1118/1.1513158|pmid=12462733|bibcode=2002MedPh..29.2655S|s2cid=16184656|issn=2473-4209}}
- Software tools for x-ray spectrum modeling (spektr).{{Cite journal|last1=Siewerdsen|first1=J. H.|last2=Waese|first2=A. M.|last3=Moseley|first3=D. J.|last4=Richard|first4=S.|last5=Jaffray|first5=D. A.|date=November 2004|title=Spektr: a computational tool for x-ray spectral analysis and imaging system optimization|journal=Medical Physics|volume=31|issue=11|pages=3057–3067|doi=10.1118/1.1758350|issn=0094-2405|pmid=15587659|bibcode=2004MedPh..31.3057S|s2cid=11144760}}{{Cite journal|last1=Punnoose|first1=J.|last2=Xu|first2=J.|last3=Sisniega|first3=A.|last4=Zbijewski|first4=W.|last5=Siewerdsen|first5=J. H.|date=2016-08-01|title=Technical Note: spektr 3.0—A computational tool for x-ray spectrum modeling and analysis|journal=Medical Physics|language=en|volume=43|issue=8Part1|pages=4711–4717|doi=10.1118/1.4955438|pmid=27487888|pmc=4958109|bibcode=2016MedPh..43.4711P|issn=2473-4209}}
References
{{Reflist|2}}
External links
- [http://istar.jhu.edu/ Laboratory for Imaging in Surgery, Therapy, and Radiology.]
- [http://carnegie.jhu.edu/ Carnegie Center for Surgical Innovation.]
- [https://www.aapm.org/education/VL/vl.asp?id=208 AAPM Lecture: C-arm Computed Tomography.]
{{DEFAULTSORT:Siewerdsen, Jeffrey}}
Category:American biomedical engineers
Category:Johns Hopkins University faculty
Category:University of Minnesota College of Science and Engineering alumni