John Puskas

{{Short description|American cardiac surgeon and inventor}}

{{Infobox medical person|profession=Surgeon|work_institutions=Icahn School of Medicine at Mount Sinai|research_field=Robotic and hybrid coronary bypass grafting, mitral valve repair, Atrial Fibrillation, novel artificial heart valves, arterial bypass grafting|name=John D. Puskas|citizenship=United States|occupation=Cardiovascular surgeon, researcher, educator|education=Princeton University

Harvard Medical School

Massachusetts General Hospital

Toronto General Hospital

Emory University|website=https://www.mountsinai.org/profiles/john-d-puskas}}

John D. Puskas is an American researcher, author, inventor and cardiovascular surgeon. As of 2022, he is Professor, Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai,{{Cite web |title=John Puskas {{!}} CTSNet |url=https://www.ctsnet.org/home/jpuskas |access-date=2022-06-17 |website=www.ctsnet.org}} and chairman, Department of Cardiovascular Surgery at Mount Sinai Morningside, Mount Sinai Beth Israel and Mount Sinai West. He holds 11 U.S. patents and co-founded the International Coronary Congress and the International Society for Coronary Artery Surgery.{{Cite web |title=India's first International Coronary Congress Inaugurated by Hon'ble President of India Shri Pranab Mukherjee - Core Sector Communique |url=https://www.corecommunique.com/indias-first-international-coronary-congress-inaugurated-honble-president-india-shri-pranab-mukherjee/ |access-date=2022-08-25 |language=en-US}} He is credited by ResearchGate with 330 publications and 15,234 citations{{Cite web |title=ResearchGate |url=https://www.researchgate.net/profile/John-Puskas |access-date=17 June 2022}} and as of 2022 Scopus reports an h-index of 62.{{Cite web |title=Scopus preview - Puskas, John Daniel - Author details - Scopus |url=https://www.scopus.com/authid/detail.uri?authorId=7004277063 |access-date=2022-08-25 |website=www.scopus.com}} Puskas is known for advancing coronary artery bypass (CABG) surgery by refining surgical techniques for all-arterial, off-pump CABG and inventing finer instruments to be used for advanced coronary bypass surgical procedures.{{Cite journal |title=Less Invasive Approaches to Coronary Artery Bypass Grafting: Off-Pump Coronary Artery Bypass |url=https://www.optechtcs.com/article/S1522-2942(10)00100-5/fulltext |access-date=17 June 2022 |journal=Operative Techniques in Thoracic and Cardiovascular Surgery|year=2010 |doi=10.1053/j.optechstcvs.2010.08.005 |last1=Myung |first1=Richard J. |last2=Halkos |first2=Michael E. |last3=Puskas |first3=John D. |volume=15 |issue=3 |pages=186–193 |doi-access=free }} He is credited with performing the first totally thoracoscopic bilateral pulmonary vein isolation procedure.{{Cite web |title=CCC Symposium |url=https://www.cccsymposiumlive.com/faculty/1412 |access-date=2022-06-17 |website=www.cccsymposiumlive.com |archive-date=2022-08-25 |archive-url=https://web.archive.org/web/20220825104655/https://www.cccsymposiumlive.com/faculty/1412 |url-status=dead }} He is the co-editor of State of the Art Surgical Coronary Revascularization,{{Cite book |last1=Taggart |first1=David P. |url=https://books.google.com/books?id=KK8SEAAAQBAJ&q=Mastery+of+Techniques+in+Cardiac+Surgery+puskas+yanagawa |title=State of the Art Surgical Coronary Revascularization |last2=Puskas |first2=John D. |date=2021 |publisher=Oxford University Press |isbn=978-0-19-875878-5 |language=en}}{{Cite book |url=https://global.oup.com/academic/product/state-of-the-art-surgical-coronary-revascularization-9780198758785?cc=us&lang=en& |title=State of the Art Surgical Coronary Revascularization |date=2021-04-04 |publisher=Oxford University Press |isbn=978-0-19-875878-5 |location=Oxford, New York}} the first textbook solely devoted to coronary artery surgery.{{Cite book |url=https://oxfordmedicine.com/view/10.1093/med/9780198758785.001.0001/med-9780198758785 |title=State of the Art Surgical Coronary Revascularization |year=2020 |publisher=Oxford University Press |isbn=978-0-19-181867-7 |language=en-US |doi=10.1093/med/9780198758785.001.0001 |editor-last1=Taggart |editor-last2=Puskas |editor-first1=David P. |editor-first2=John D. }}

In 2021, Puskas ran the New York City Marathon with his patient who, in 2018, suffered cardiac arrest and was clinically dead for five minutes, but recovered after all-arterial CABG.{{Cite web |last=Hambleton |first=Brittany |date=2021-11-07 |title=WATCH: Man running the NYC marathon with doctor who saved his life |url=https://runningmagazine.ca/the-scene/watch-man-running-the-nyc-marathon-with-doctor-who-saved-his-life/ |access-date=2022-08-25 |website=Canadian Running Magazine |language=en-US}} Their trainer, John Garlepp was another CABG patient of Puskas.{{Cite web |date=2021-11-07 |title=2021 TCS NYC Marathon: Man running the NYC Marathon with surgeon who saved him |url=https://abc7ny.com/man-died-while-running-heart-surgery-2021-tcs-new-york-city-marathon-nyc/11207938/ |access-date=2022-08-25 |website=ABC7 New York |language=en}}

Career

= Life and education =

Born in 1960, Puskas received his MD at Harvard Medical School in 1986 and in 1991, a Master of Science in Surgical Science (MSc) at the University of Toronto. Post-graduate training included a general surgery internship and residency, department of surgery, Massachusetts General Hospital; fellowship in cardiothoracic surgery at Emory University Hospitals, Atlanta, a lung transplantation research fellowship, division of thoracic surgery, Toronto General Hospital; and an advanced fellowship in tracheal surgery, Massachusetts General Hospital, Division of General Thoracic Surgery.{{Cite web |title=Dr. John D. Puskas - Thoracic & Cardiac Surgery - New York, NY |url=https://www.castleconnolly.com/top-doctors/john-d-puskas-thoracic-cardiac-surgery-98cc000376 |access-date=2022-06-17 |website=Castle Connolly |language=en}}{{Cite web |title=Dr. John Puskas, MD, Cardiothoracic Surgery Specialist - New York, NY |url=https://www.sharecare.com/doctor/dr-john-d-puskas |access-date=2022-06-17 |website=Sharecare |language=en}}

= Research =

Puskas research concentrations include arterial bypass grafting, robotic and hybrid coronary bypass grafting, novel designs and materials for artificial heart valves, mitral and aortic valve repair and replacement, surgical and medical treatments for people with atrial fibrillation and surgical instruments for adult cardiac surgery.{{Cite web |title=John Puskas {{!}} CTSNet |url=https://www.ctsnet.org/home/jpuskas |access-date=2022-08-25 |website=www.ctsnet.org}}

He founded the Emory University Cardiothoracic Clinical Research Unit in 2005 and was a founding investigator in the creation of the NIH Cardiothoracic Surgery Trials Network in 2007; he has served on the steering committee of that NIH Network since that time. As of 2022, he has served as the principal investigator (PI) of five multi-center FDA investigatory drug/device exemption trials in cardiovascular surgery. At Mount Sinai Health System, he founded and directs the Cardiovascular Clinical Research Unit at Mount Sinai Morningside and Mount Sinai Beth Israel Hospitals to create a multidisciplinary collaborative clinical research infrastructure allowing clinical cardiologists and surgeons to enroll patients in multiple trials. He led 47 clinical sites nationwide to conduct the first RCT of hybrid coronary revascularization.{{Cite web |title=NIH RePorter |url=https://reporter.nih.gov/search/O3GMONuzgEC0IEhZSSmomQ/projects |access-date= |website=NIH Reporter}} He is listed on NIH RePORTER with 12 NHLBI PI roles.{{Cite web |title=NIH RePorter |url=https://reporter.nih.gov/search/9Nbu5XYRfU-MLQrdeeH_8g/projects |access-date=17 June 2022 |website=NIH}}

= Clinical and practice =

Puskas performs cardiovascular surgical procedures including all-arterial coronary bypass grafting, minimally invasive robotic coronary bypass surgery, hybrid coronary revascularization, off-pump coronary artery bypass surgery, ablation surgery for the treatment of atrial fibrillation, mitral valve repair/replacement, aortic valve replacement, valve-sparing aortic root replacement and surgery for aortic dissection.{{Cite journal |last1=Puskas |first1=John D. |last2=Williams |first2=Willis H. |last3=Mahoney |first3=Elizabeth M. |last4=Huber |first4=Philip R. |last5=Block |first5=Peter C. |last6=Duke |first6=Peggy G. |last7=Staples |first7=James R. |last8=Glas |first8=Katherine E. |last9=Marshall |first9=J. Jeffrey |last10=Leimbach |first10=Mark E. |last11=McCall |first11=Susan A. |date=2004-04-21 |title=Off-Pump vs Conventional Coronary Artery Bypass Grafting: Early and 1-Year Graft Patency, Cost, and Quality-of-Life OutcomesA Randomized Trial |journal=JAMA |volume=291 |issue=15 |pages=1841–1849 |doi=10.1001/jama.291.15.1841 |pmid=15100202 |issn=0098-7484|doi-access=free }} He performed the first triple off-pump bypass surgery using minimally invasive coronary artery bypass graft instrumentation in 1997.{{Cite web |title=Emory Surgery Newsletter {{!}} February 28, 2014 |url=http://www.surgery.emory.edu/newsletter/emory-surgery-february-28-2014.html |access-date=2022-08-25 |website=www.surgery.emory.edu}} Between 1996 and 2022, he performed approximately 300 cardiac surgical cases annually, specializing in multiple arterial CABG and robotic CABG. In 2019, Puskas, with Gianluca Torregrossa, MD, successfully performed two totally endoscopic coronary arterial bypass surgeries (TECABs) making Mount Sinai the only New York State health system qualified to make the procedure available.{{Cite web |title=TECAB reduces risk, expedites recovery for bypass patients |url=https://cardiovascularbusiness.com/topics/clinical/interventional-cardiology/tecab-reduces-risk-expedites-recovery-bypass-patients |access-date=2022-08-25 |website=cardiovascularbusiness.com |date=10 June 2019 |language=en}} As of 2022, Puskas has served as President of the International Society for Minimally Invasive Cardiothoracic Surgery (2009) and the International Society for Coronary Artery Surgery.

= U.S. patents =

class="wikitable"

|+Specifications

!Patent No

!Title

!Licensed to

6,042,538

|Device for Endoscopic Vessel Harvesting

|Medtronic

6,479,523

|Pharmacological Drug Combination in Vagal-Induced Asystole

|Medtronic

6,429,217

|Pharmacological Drug Combination in Vagal-Induced Asystole

|Medtronic

6,778,854

|Methods of Indirectly Stimulating the Vagus nerve with an Electrical Field

|Medtronic

6,656,960

|Methods of Performing Vagal-Induced Asystol

|Medtronic

7,072,720

|Devices and Methods for Vagus Nerve Stimulation

|Medtronic

7,142,910

|Methods of Indirectly Stimulating the Vagus Nerve with an Electrical Field

|Medtronic

7,310,552

|Apparatus for Indirectly Stimulating the Vagus Nerve with an Electrical Field

|

7,340,299

|Methods of Indirectly Stimulating the Vagus Nerve to Achieve Controlled Asystole

|

7,840,278

|Devices and Methods for Vagus Nerve Stimulation

|

12/134,842

|Dual Closing Guide for a Surgical Instrument

|Scanlan International, Inc.

14/030,606

|Novel Sternal Retractor

|Scanlan International, Inc.

= Present societies =

Publications

= Editorial =

= Peer reviewed =

PubMed lists 320 publications as of 2022.{{Cite web |title=Puskas JD - Search Results - PubMed |url=https://pubmed.ncbi.nlm.nih.gov/?term=Puskas+JD&cauthor_id=22000786 |access-date=2022-06-17 |website=PubMed |language=en}} A short list ranked by citations include:

Smith, P. K., Puskas, J. D., Ascheim, D. D., Voisine, P., Gelijns, A. C., Moskowitz, A. J., ... & Michler, R. E. (2014). Surgical treatment of moderate ischemic mitral regurgitation. New England Journal of Medicine, 371(23), 2178–2188; 273 citations{{Cite journal |last1=Smith |first1=Peter K. |last2=Puskas |first2=John D. |last3=Ascheim |first3=Deborah D. |last4=Voisine |first4=Pierre |last5=Gelijns |first5=Annetine C. |last6=Moskowitz |first6=Alan J. |last7=Hung |first7=Judy W. |last8=Parides |first8=Michael K. |last9=Ailawadi |first9=Gorav |last10=Perrault |first10=Louis P. |last11=Acker |first11=Michael A. |date=2014-12-04 |title=Surgical Treatment of Moderate Ischemic Mitral Regurgitation |url=https://doi.org/10.1056/NEJMoa1410490 |journal=New England Journal of Medicine |volume=371 |issue=23 |pages=2178–2188 |doi=10.1056/NEJMoa1410490 |issn=0028-4793 |pmc=4303577 |pmid=25405390}}

Puskas, J. D., Thourani, V. H., Marshall, J. J., Dempsey, S. J., Steiner, M. A., Sammons, B. H., ... & Guyton, R. A. (2001). Clinical outcomes, angiographic patency, and resource utilization in 200 consecutive off-pump coronary bypass patients. The Annals of thoracic surgery, 71(5), 1477–1484; 324 citations{{Cite journal |last1=Puskas |first1=John D |last2=Thourani |first2=Vinod H |last3=Marshall |first3=J. Jeffrey |last4=Dempsey |first4=Steven J |last5=Steiner |first5=Mark A |last6=Sammons |first6=Bonnie H |last7=Brown |first7=W. Morris |last8=Gott |first8=John Parker |last9=Weintraub |first9=William S |last10=Guyton |first10=Robert A |date=2001-05-01 |title=Clinical outcomes, angiographic patency, and resource utilization in 200 consecutive off-pump coronary bypass patients |url=https://www.sciencedirect.com/science/article/pii/S0003497501024730 |journal=The Annals of Thoracic Surgery |language=en |volume=71 |issue=5 |pages=1477–1484 |doi=10.1016/S0003-4975(01)02473-0 |pmid=11383786 |issn=0003-4975}}

Gaudino, M., Benedetto, U., Fremes, S., Biondi-Zoccai, G., Sedrakyan, A., Puskas, J. D., ... & Taggart, D. P. (2018). Radial-artery or saphenous-vein grafts in coronary-artery bypass surgery. New England Journal of Medicine, 378(22), 2069–2077; 295 citations{{Cite journal |last1=Gaudino |first1=Mario |last2=Benedetto |first2=Umberto |last3=Fremes |first3=Stephen |last4=Biondi-Zoccai |first4=Giuseppe |last5=Sedrakyan |first5=Art |last6=Puskas |first6=John D. |last7=Angelini |first7=Gianni D. |last8=Buxton |first8=Brian |last9=Frati |first9=Giacomo |last10=Hare |first10=David L. |last11=Hayward |first11=Philip |date=2018-05-31 |title=Radial-Artery or Saphenous-Vein Grafts in Coronary-Artery Bypass Surgery |journal=New England Journal of Medicine |volume=378 |issue=22 |pages=2069–2077 |doi=10.1056/NEJMoa1716026 |issn=0028-4793 |pmid=29708851|s2cid=13752332 |doi-access=free |hdl=1983/da0c0152-dab6-4cc0-aca6-60fc9b131219 |hdl-access=free }}

Gillinov, A. M., Gelijns, A. C., Parides, M. K., DeRose Jr, J. J., Moskowitz, A. J., Voisine, P., ... & Argenziano, M. (2015). Surgical ablation of atrial fibrillation during mitral-valve surgery. New England Journal of Medicine, 372(15), 1399–1409; 261 citations{{Cite journal |last1=Gillinov |first1=A. Marc |last2=Gelijns |first2=Annetine C. |last3=Parides |first3=Michael K. |last4=DeRose |first4=Joseph J. |last5=Moskowitz |first5=Alan J. |last6=Voisine |first6=Pierre |last7=Ailawadi |first7=Gorav |last8=Bouchard |first8=Denis |last9=Smith |first9=Peter K. |last10=Mack |first10=Michael J. |last11=Acker |first11=Michael A. |date=2015-04-09 |title=Surgical Ablation of Atrial Fibrillation during Mitral-Valve Surgery |url=https://doi.org/10.1056/NEJMoa1500528 |journal=New England Journal of Medicine |volume=372 |issue=15 |pages=1399–1409 |doi=10.1056/NEJMoa1500528 |issn=0028-4793 |pmc=4664179 |pmid=25853744}}

El-Chami, M. F., Kilgo, P., Thourani, V., Lattouf, O. M., Delurgio, D. B., Guyton, R. A., ... & Puskas, J. D. (2010). New-onset atrial fibrillation predicts long-term mortality after coronary artery bypass graft. Journal of the American College of Cardiology, 55(13), 1370–1376; 338 citations{{Cite journal |last1=El |first1=-Chami Mikhael F. |last2=Kilgo |first2=Patrick |last3=Thourani |first3=Vinod |last4=Lattouf |first4=Omar M. |last5=Delurgio |first5=David B. |last6=Guyton |first6=Robert A. |last7=Leon |first7=Angel R. |last8=Puskas |first8=John D. |date=2010-03-30 |title=New-Onset Atrial Fibrillation Predicts Long-Term Mortality After Coronary Artery Bypass Graft |journal=Journal of the American College of Cardiology |volume=55 |issue=13 |pages=1370–1376 |doi=10.1016/j.jacc.2009.10.058|pmid=20338499 |doi-access= }}

= Books and chapters =

State of the Art Surgical Coronary Revascularization. {{ISBN|0198758782}}

Winston AD and Puskas JD. "Techniques for Multivessel OPCAB". Minimally Invasive Cardiac Surgery. 2ndEdition, edited by Oz MC and Goldstein DJ, Humana Press, 2003.{{Cite web |last=Puskas |first=John D. |title=Tips and Techniques for Multivessel OPCAB |url=https://www.optechtcs.com/article/S1522-2942(06)00053-5/pdf |access-date=August 24, 2022 |website=Operative Techniques}}

Sharoni E and Puskas JD. "Techniques in Multivessel OPCAB". Operative Cardiac Surgery, edited by Gardner T J and Spray TL, Arnold Publishers, 2004.

Thourani VH and Puskas JD. "Coronary Artery Bypass Procedures·Medical Management of the Surgical Patient." Fourth Edition, edited by Lubin MF, Walker HK, Smith RB III, 2006.{{Citation |last1=Keeling |first1=W. Brent |title=Coronary artery bypass procedures |date=2013 |url=https://www.cambridge.org/core/books/medical-management-of-the-surgical-patient/coronary-artery-bypass-procedures/C8C4015DD5FE6C9979AC082708C3F4BC |work=Medical Management of the Surgical Patient: A Textbook of Perioperative Medicine |pages=557–564 |editor-last=Lubin |editor-first=Michael F. |edition=5 |place=Cambridge |publisher=Cambridge University Press |isbn=978-1-107-00916-5 |access-date=2022-08-25 |last2=Thourani |first2=Vinod H. |editor2-last=Winawer |editor2-first=Neil H. |editor3-last=Dodson |editor3-first=Thomas F.}}

Song HK and Puskas JD. "Off-pump Coronary Artery Bypass Surgery". Mastery of Cardiothoracic Surgery, 2nd Edition, Lippincott Williams and Wilkins, New York, 2007.{{Cite journal |last1=Puskas |first1=John D. |last2=Thourani |first2=Vinod H. |last3=Kilgo |first3=Patrick |last4=Cooper |first4=William |last5=Vassiliades |first5=Thomas |last6=Vega |first6=J. David |last7=Morris |first7=Cullen |last8=Chen |first8=Edward |last9=Schmotzer |first9=Brian J. |last10=Guyton |first10=Robert A. |last11=Lattouf |first11=Omar M. |title=Off-pump coronary artery bypass disproportionately benefits high-risk patients |url=https://pubmed.ncbi.nlm.nih.gov/19766798 |journal=The Annals of Thoracic Surgery |year=2009 |volume=88 |issue=4 |pages=1142–1147 |doi=10.1016/j.athoracsur.2009.04.135 |issn=1552-6259 |pmid=19766798}}

Richard J. Myung and John D. Puskas. "Off-Pump Coronary Artery Bypass Grafting for Repeat Coronary Revascularization", Redo Cardiac Surgery in Adults, 2nd Edition, Edited by Venkat R. Machiraju, Hartzell V. Schaff and Lars G. Svensson. Springer. 2011.{{Cite journal |last1=Puskas |first1=John D. |last2=Williams |first2=Willis H. |last3=O'Donnell |first3=Robert |last4=Patterson |first4=Randolph E. |last5=Sigman |first5=Steven R. |last6=Smith |first6=A. Shannon |last7=Baio |first7=Kim T. |last8=Kilgo |first8=Patrick D. |last9=Guyton |first9=Robert A. |title=Off-pump and on-pump coronary artery bypass grafting are associated with similar graft patency, myocardial ischemia, and freedom from reintervention: long-term follow-up of a randomized trial |url=https://pubmed.ncbi.nlm.nih.gov/21619980 |journal=The Annals of Thoracic Surgery |year=2011 |volume=91 |issue=6 |pages=1836–1842; discussion 1842–1843 |doi=10.1016/j.athoracsur.2010.12.043 |issn=1552-6259 |pmid=21619980}}

Michael E. Halkos, John D. Puskas. "Minimally Invasive Coronary Artery Bypass Graft to Cardiac Surgery: Recent Advances and Techniques", 2012.{{Cite book |last1=Moorjani |first1=Narain |url=https://books.google.com/books?id=EUbBAQAAQBAJ&dq=Minimally+Invasive+Coronary+Artery+Bypass+Graft+to+Cardiac+Surgery%3A+Recent+Advances+and+Techniques+puskas+halkos&pg=PA1 |title=Cardiac Surgery: Recent Advances and Techniques |last2=Ohri |first2=Sunil K. |last3=Wechsler |first3=Andrew |date=2013-12-17 |publisher=CRC Press |isbn=978-1-4441-3756-9 |language=en}}

Yanagawa B and Puskas JD. “Off-Pump Coronary Artery Bypass Grafting”, in Mastery of Techniques in Cardiac Surgery, 2016.

Michael E. Halkos, Emmanuel Moss, and John D. Puskas. “Chapter 2 Off-pump versus on-pump coronary artery bypass grafting”, in Core Concepts in Cardiac Surgery, Edited by David Taggart and Yasir Abu-Omar, Oxford University Press, 2018.

Bobby Yanagawa, Michael E. Halkos, John D. Puskas. “Chapter 21: Myocardial Revascularization Without Cardiopulmonary Bypass”, in Cardiac Surgery in the Adult, 5e, Edited by Lawrence H. Cohn, David H. Adams, Cenveo® Publisher Services, 2018.

See also

  • Mario Gaudino - cardiac surgeon and expert in coronary revascularization

References