K. B. Sainis

File:University of Pune, Pune.jpg

Born on 2 October 1949, K. B. Sainis earned a master's degree in biochemistry (MSc) from Savitribai Phule Pune University and did a one-year course in biology and radiobiology at Bhabha Atomic Research Centre (BARC).{{Cite web |url=http://www.unscear.org/unscear/en/about_us/bio_kbsainis.html |title=Professor Dr. Krishna B. Sainis on UNSCEAR |date=2017 |publisher=UN Scientific Committee on the Effects of Atomic Radiation |access-date=13 March 2017 |archive-date=12 May 2021 |archive-url=https://web.archive.org/web/20210512160331/http://www.unscear.org/unscear/en/about_us/bio_kbsainis.html |url-status=dead }} Upon completion of the course in 1972, he joined BARC as a Scientific Officer while continuing his doctoral studies at Pune University and secured a PhD in biophysics in 1980. Taking a sabbatical, he did his post-doctoral studies at the New England Medical Centre of Tufts University School of Medicine and, with the assistance of an IAEA fellowship, he completed his studies at University College London at its ICRF Tumor Immunology Unit.

Returning to BARC, he served in many positions, heading the Immunology Section and the Cell Biology Division and serving as the associate director of the Bioscience Group. He became director of the Bio-Medical Group in 2006, with the responsibility of six divisions.{{Cite web |url=https://vidwan.inflibnet.ac.in/profile/2040 |title=Dr. Krishna Balaji Sainis on Vidwan |date=2017 |publisher=Vidwan Iflibnet}} During his service at BARC, he has also been working as a faculty at the department of Life Sciences of the Homi Bhabha National Institute where he is a senior professor.{{Cite web |url=http://www.hbni.ac.in/faculty/finf_na.html?fnm=Sainis%20Krishna%20Balaji&ci=BARC&dsp=Life%20Sciences&dsg=Sr.%20Professor |title=Senior professor - Life Sciences |date=2017 |publisher=Homi Bhabha National Institute |access-date=13 March 2017 |archive-date=12 May 2021 |archive-url=https://web.archive.org/web/20210512160332/http://www.hbni.ac.in/faculty/finf_na.html?fnm=Sainis%20Krishna%20Balaji&ci=BARC&dsp=Life%20Sciences&dsg=Sr.%20Professor |url-status=dead }}

Sainis is married to Jayashree Krishna Sainis, a biochemist, and the family lives in Navi Mumbai.{{Cite web|url=http://www.nasi.org.in/fellows.asp?RsFilter=S |title=NASI fellows |date=2017 |publisher=National Academy of Sciences, India |url-status=dead |archiveurl=https://web.archive.org/web/20160316043224/http://nasi.org.in/fellows.asp?RsFilter=S |archivedate=2016-03-16 }}

Sainis' studies in immunobiology have covered how T Cells and their receptors influence immune response to DNA in mycobacterial antigens and lupus nephritis, an autoimmune disease.{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | page=71 | date=1999 | access-date=13 March 2017 | archive-url=https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf | archive-date=4 March 2016 | url-status=dead }} He headed a group of scientists at BARC who were involved in research on immunomodulators based on plants.{{cite book|author1=PHISPC|author2=Burma and Chakravorty|title=From Physiology and Chemistry to Biochemistry|url=https://books.google.com/books?id=F0o7BAAAQBAJ&pg=PA468|publisher=Pearson Education India|isbn=978-81-317-5373-6|pages=468–|year=1900}} His studies have been documented and cited in texts and articles.{{Refn|group=note|Please see Selected bibliography section}}{{Cite web |url=https://pubmed.ncbi.nlm.nih.gov/?term=Sainis%20KB%5BAuthor%5D&cauthor=true |title=Sainis KB [Author] |date=2017 |publisher=US National Library of Medicine}}{{cite book|author=Atta-ur-Rahman|title=Studies in Natural Products Chemistry|url=https://books.google.com/books?id=yZIxDQAAQBAJ&pg=PA486|date=17 February 2017|publisher=Elsevier Science|isbn=978-0-444-63937-0|pages=486–}}{{cite book|author=United Nations. Scientific Committee on the Effects of Atomic Radiation|title=Effects of Ionizing Radiation: UNSCEAR 2006 Report to the General Assembly, with Scientific Annexes|url=https://books.google.com/books?id=xt-ZOQVfmj0C&pg=PA193|year=2009|publisher=United Nations Publications|isbn=978-92-1-142270-2|pages=193–}}{{cite book|author1=Thomas Bechtold|author2=Rita Mussak|title=Handbook of Natural Colorants|url=https://books.google.com/books?id=hBFxuH5uXyIC&pg=PA253|date=6 April 2009|publisher=John Wiley & Sons|isbn=978-0-470-74496-3|pages=253–}}{{cite book|author=Dr. Mohd Yusuf|title=GREEN DYES AND PIGMENTS: CLASSES AND APPLICATIONS|date=27 February 2016 |url=https://books.google.com/books?id=nlpmDAAAQBAJ&pg=PA163|publisher=Lulu.com|isbn=978-1-329-93291-3|pages=163–}} He has also written chapters in books published by others.{{cite book|author=Shakti N. Upadhyay|title=Immunopharmacology: Strategies for Immunotherapy|url=https://books.google.com/books?id=hs8qglYfwHAC&pg=PR10|year=1999|publisher=CRC Press|isbn=978-0-8493-0951-9|pages=10–}}{{cite book|author1=Vibha Rani|author2=Umesh Chand Singh Yadav|title=Free Radicals in Human Health and Disease|url=https://books.google.com/books?id=aTppBQAAQBAJ&pg=PA349|date=14 November 2014|publisher=Springer|isbn=978-81-322-2035-0|pages=349–}}{{Cite book |url=https://www.amrita.edu/publication/immunomodulatory-properties-stem-extracts-tinospora-cordifolia-cell-targets-and-active |title=Immunomodulation - Immunomodulatory properties of stem extracts of Tinospora cordifolia: cell targets and active principles |last=K. B. Sainis, Sumariwalla, P. F., Goel, A., Chintalwar, G. J., Sipahimalani, A. T., and Banerji, A. |publisher=Narosa Publishing House |year=1997 |editor-last=S.N. Upadhyay |page=155}}

Sainis has been associated with two international agencies. He served as president of the Standing Advisory Group on Nuclear Applications (SAGNA) of the International Atomic Energy Agency (IAEA) in 2012, and since 1999 has served as the Indian representative on the United Nations Scientific Committee on the Effects of Atomic Radiation.{{cite book|author=United Nations. Scientific Committee on the Effects of Atomic Radiation|title=Report of the United Nations Scientific Committee on the Effects of Atomic Radiation: Fifty-sixth Session (10-18 July 2008).|url=https://books.google.com/books?id=ltAlYDs1oMkC&pg=PA30|year=2008|publisher=United Nations Publications|pages=30–|id=GGKEY:B5URFLG7851}}{{cite book|author=United Nations. Scientific Committee on the Effects of Atomic Radiation|title=Sources and Effects of Ionizing Radiation: Sources|url=https://books.google.com/books?id=57YmhD4ZBpQC&pg=PA16|year=2000|publisher=United Nations Publications|isbn=978-92-1-142238-2|pages=16–}}

Sainis is the president of the Mumbai Immunology Group at Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) of the Tata Memorial Centre{{Cite web |url=http://www.actrec.gov.in/MIG-index/ECM2.html |title=President - Mumbai Immunology Group |date=2017 |publisher=Mumbai Immunology Group - ACTREC |access-date=13 March 2017 |archive-date=19 June 2022 |archive-url=https://web.archive.org/web/20220619001057/http://www.actrec.gov.in/MIG-index/ECM2.html |url-status=dead }} and a former vice president of the Maharashtra Academy of Sciences.{{Cite web |url=http://www.tifr.res.in/~aset/sainis-talk3.pdf |title=Special ASET Colloquium |date=2017 |publisher=Tata Institute of Fundamental Research}} He is an honorary adviser to the Society for Free Radical Research India (SFRR-India);{{Cite web |url=http://www.sfrr-india.org/Committee.html |title=Current Managing Committee (2016-2018) |date=2017 |publisher=SFFR India}}{{Cite web |url=http://www.aiims.edu/aiims/events/sfrr/faculty.htm |title=Honorary Advisers |date=2017 |publisher=AIIMS}} a member of the Advisory Committee of the National Training Program on Radiation Processing of Food for Food and Quarantine Inspectors & Quality Control Personnel organized by Department of Atomic Energy in association with BARC in February 2013;{{Cite web |url=http://www.gcnep.gov.in/programs/details/NTP-RPF0213-Brochure.pdf |title=Advisory Committee National Training Program on Radiation Processing |date=2017 |publisher=Global Centre for Nuclear Energy Partnership}} and a member of the Indian Immunology Society.{{Cite web |url=http://www.indianimmunology.org/MOM_GBM_2007_NARI.pdf |title=IIS Member |date=2017 |publisher=Indian Immunology Society |access-date=13 March 2017 |archive-date=12 May 2021 |archive-url=https://web.archive.org/web/20210512160331/http://www.indianimmunology.org/MOM_GBM_2007_NARI.pdf |url-status=dead }}

He was previously associated with ongoing education programs such as the XVII Training Workshop on Radiation Emergency Preparedness for Medical Officers,{{Cite web |url=http://www.barc.gov.in/publications/nl/2008/20080403.pdf |title=XVII Training Workshop on Radiation Emergency Preparedness for Meeical Officers |date=2017 |publisher=BARC |access-date=13 March 2017 |archive-date=22 May 2013 |archive-url=https://web.archive.org/web/20130522135354/http://barc.gov.in/publications/nl/2008/20080403.pdf |url-status=dead }} the Refresher Course 2013 of the Indian Women Scientists Association,{{Cite web |url=http://www.iwsa.net/Act-refresher.html |title=Refresher Course 2013 |date=2017 |publisher=Indian Women Scientists Association |access-date=13 March 2017 |archive-date=13 June 2019 |archive-url=https://web.archive.org/web/20190613124105/http://www.iwsa.net/Act-refresher.html |url-status=dead }} and the AKRUTI Technology Package for Rural Deployment of BARC.{{Cite web |url=http://www.barc.gov.in/akruti-tp/akforce_p.html |title=AKRUTI Technology Package for Rural Deployment |date=2017 |publisher=BARC |access-date=13 March 2017 |archive-date=2 November 2018 |archive-url=https://web.archive.org/web/20181102163241/http://www.barc.gov.in/akruti-tp/akforce_p.html |url-status=dead }} He has delivered several invited speeches or keynote addresses{{Cite web |url=http://www.sarkarimirror.com/the-director-bio-medical-group-barc-mumbai-dr-k-b-sainis-addressing-the-media-at-the-opening-of-media-interaction-on-radiation-and-quality-of-human-life-in-chennai/ |title=The Director, Bio-Medical Group, BARC, Mumbai, Dr. K.B. Sainis addressing |date=25 September 2013 |publisher=Sarkari Mirror}}{{Cite web |url=http://www.tifr.res.in/~aset/Bhabha/talk090310.html |title=RADIATION AND SOCIETY: Benefits and Apprehensions |date=2017 |publisher=Tata Institute of Fundamental Research}} and is a reviewer for Hindawi journals.{{Cite web |url=https://www.hindawi.com/countries/in/reviewers/67/ |title=India: Reviewers Hindawi journals |date=2017 |website=Hindawi |access-date=13 March 2017 |archive-date=3 July 2018 |archive-url=https://web.archive.org/web/20180703133819/https://www.hindawi.com/countries/in/reviewers/67/ |url-status=dead }}

The Council of Scientific and Industrial Research awarded Sainis the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, in 1994.{{Cite web |url=http://www.csir.res.in/external/heads/career/award/BPRIZE/Medical_SCIENCES.htm |archive-url=https://web.archive.org/web/20130224074105/http://www.csir.res.in/External/Heads/career/award/BPRIZE/Medical_SCIENCES.htm |url-status=dead |archive-date=24 February 2013 |title=Medical Sciences |date=2017 |publisher=Council of Scientific and Industrial Research }}{{cite web | url=http://ssbprize.gov.in/Content/AwardeeList.aspx | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | accessdate=12 November 2016}} The National Academy of Sciences, India elected him as a fellow in 2002.{{Cite web |url=http://nasi.nic.in/ZONE%20-2015.pdf |title=Zone wise list of Fellows & Honorary Fellows |date=2017 |publisher=National Academy of Sciences, India}} He is also an elected fellow of the Maharashtra Academy of Sciences.{{Cite web |url=http://mahascience.org/files/Fellowship/files/academyMembers.htm#s |title=MAS fellows |date=2017 |publisher=Maharashtra Academy of Sciences}}

• {{Cite book |url=https://www.amrita.edu/publication/immunomodulatory-properties-stem-extracts-tinospora-cordifolia-cell-targets-and-active |title=Immunomodulation - Immunomodulatory properties of stem extracts of Tinospora cordifolia: cell targets and active principles |author=K. B. Sainis, Sumariwalla, P. F., Goel, A., Chintalwar, G. J., Sipahimalani, A. T., and Banerji, A. |publisher=Narosa Publishing House |year=1997 |editor-last=S.N. Upadhyay |page=155}}
• {{cite book|author=Shakti N. Upadhyay|title=Immunopharmacology: Strategies for Immunotherapy|year=1999|publisher=CRC Press|isbn=978-0-8493-0951-9|pages=10–}}
• {{cite book|author1=Vibha Rani|author2=Umesh Chand Singh Yadav|title=Free Radicals in Human Health and Disease|date=14 November 2014|publisher=Springer|isbn=978-81-322-2035-0|pages=349–}}

• {{Cite journal |vauthors=Raghu R, Sharma D, Ramakrishnan R, Khanam S, Chintalwar GJ, Sainis KB |title=Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia |journal=Immunol. Lett. |date=2009 |volume=23 |issue=1 |pages=60–71 |doi=10.1016/j.imlet.2009.02.005|pmid=19428553 }}
• {{Cite journal |last=Deepak Sharma, S. Santosh Kumar, Rahul Checker, Rashmi Raghu, Shazia Khanam, Sunil Krishnan, Krishna Balaji Sainis |title=Spatial distribution, kinetics, signaling and cytokine production during homeostasis driven proliferation of CD4+ T cells |journal=Mol. Immunol. |date=2009 |volume=46 |issue=11–12 |pages=2403–2412 |doi=10.1016/j.molimm.2009.04.019|pmid=19447493 |pmc=3090723 }}
• {{Cite journal |vauthors=Checker R, Sandur SK, Sharma D, Patwardhan RS, Jayakumar S, Kohli V, Sethi G, Aggarwal BB, Sainis KB |title=Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT |journal=PLOS ONE |date=2012 |volume=7 |issue=2 |pages=e31318 |doi=10.1371/journal.pone.0031318|pmid=22363615 |pmc=3282718 |bibcode=2012PLoSO...731318C |doi-access=free }}
• {{Cite journal |vauthors=Patwardhan RS, Checker R, Sharma D, Sandur SK, Sainis KB |title=Involvement of ERK-Nrf-2 signaling in ionizing radiation induced cell death in normal and tumor cells |journal=PLOS ONE |date=2013 |volume=8 |issue=6 |pages=e65929 |doi=10.1371/journal.pone.0065929|pmid=23776571 |pmc=3679038 |bibcode=2013PLoSO...865929P |doi-access=free }}
• {{Cite journal |vauthors=Suryavanshi S, Sharma D, Checker R, Thoh M, Gota V, Sandur SK, Sainis KB |title=Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis |journal=Free Radic Biol Med |date=2015 |volume=85 |pages=56–70 |doi=10.1016/j.freeradbiomed.2015.04.007|pmid=25872101 }}

• Immunotherapy
• Radioactive contamination

{{portal|India|Medicine}}

{{reflist|group=note|2}}

{{reflist}}

• {{cite book|author1=Kalanithi Nesaretnam|author2=Lester Packer|title=Micronutrients and Health: Molecular Biological Mechanisms|url=https://books.google.com/books?id=IelJ6STrf9YC&pg=PA56|year=2001|publisher=The American Oil Chemists Society|isbn=978-1-893997-19-6|pages=56–}}
• {{cite book|author=K G Ramawat|title=Biotechnology of Medicinal Plants: Vitalizer and Therapeutic|url=https://books.google.com/books?id=t05RAAAAMAAJ|date=8 January 2004|publisher=Science Publishers|isbn=978-1-57808-338-1}}

• {{Cite web |url=http://www.mid-day.com/articles/no-fear-if-its-nuclear/225962 |title='No fear if it's nuclear' |date=8 August 2013 |publisher=Mid-Day |work=News report}}

{{SSBPST recipients in Medical Science}}

{{Authority control}}

{{DEFAULTSORT:Sainis, K. B.}}

Category:Indian immunologists

Category:Indian medical writers

Category:1949 births

Category:Scientists from Maharashtra

Category:Savitribai Phule Pune University alumni

Category:Tufts University School of Medicine alumni

Category:Alumni of University College London

Category:Homi Bhabha National Institute

Category:Recipients of the Shanti Swarup Bhatnagar Award in Medical Science

Category:Fellows of the National Academy of Sciences, India

Category:Living people