L-fuculose-phosphate aldolase
{{infobox enzyme
| Name = L-fuculose-phosphate aldolase
| EC_number = 4.1.2.17
| CAS_number = 9024-54-8
| GO_code = 0008738
| image =
| width =
| caption =
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The enzyme L-fuculose-phosphate aldolase ({{EnzExplorer|4.1.2.17}}) catalyzes the chemical reaction
: L-fuculose-1-phosphate glycerone phosphateGlycerone phosphate is often known as dihydroxyacetone phosphate. + (S)-lactaldehyde
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-fuculose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include L-fuculose 1-phosphate aldolase, fuculose aldolase, and L-fuculose-1-phosphate lactaldehyde-lyase. This enzyme participates in fructose and mannose metabolism.
Structural studies
As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1DZU}}, {{PDB link|1DZV}}, {{PDB link|1DZW}}, {{PDB link|1DZX}}, {{PDB link|1DZY}}, {{PDB link|1DZZ}}, {{PDB link|1E46}}, {{PDB link|1E47}}, {{PDB link|1E48}}, {{PDB link|1E49}}, {{PDB link|1E4A}}, {{PDB link|1E4B}}, {{PDB link|1E4C}}, {{PDB link|1FUA}}, {{PDB link|2FK5}}, {{PDB link|2FLF}}, {{PDB link|2FUA}}, {{PDB link|2OPI}}, {{PDB link|3FUA}}, and {{PDB link|4FUA}}.
See also
References
{{reflist|1}}
- {{cite journal | vauthors = Ghalambor MA, Heath EC | date = 1966 | title = The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-d-manno-octulosonate synthetase | journal = J. Biol. Chem. | volume = 241 | pages = 3216–21 | pmid = 5330266 | issue = 13 | doi = 10.1016/S0021-9258(18)96517-8 | doi-access = free }}
- {{cite journal | vauthors = Dreyer MK, Schulz GE | date = 1993 | title = The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli | journal = J. Mol. Biol. | volume = 231 | pages = 549–53 | pmid = 8515438 | doi = 10.1006/jmbi.1993.1307 | issue = 3 }}
- {{cite journal | vauthors = Dreyer MK, Schulz GE | date = 1996 | title = Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure | journal = J. Mol. Biol. | volume = 259 | pages = 458–66 | pmid = 8676381 | doi = 10.1006/jmbi.1996.0332 | issue = 3 }}
{{Carbon-carbon lyases}}
{{Enzymes}}
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Category:Enzymes of known structure
{{4.1-enzyme-stub}}