LDB1

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.{{cite journal |vauthors=Yamashita T, Agulnick AD, Copeland NG, Gilbert DJ, Jenkins NA, Westphal H | title = Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1 | journal = Genomics | volume = 48 | issue = 1 | pages = 87–92 |date=Apr 1998 | pmid = 9503020 | doi = 10.1006/geno.1997.5163 | url = https://zenodo.org/record/1229749 }}{{cite journal |vauthors=Semina EV, Altherr MR, Murray JC | title = Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI | journal = Mamm Genome | volume = 9 | issue = 11 | pages = 921–4 |date=Dec 1998 | pmid = 9799849 | doi =10.1007/s003359900899 | s2cid = 28813194 }}{{cite web | title = Entrez Gene: LDB1 LIM domain binding 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8861}}

Interactions

LDB1 has been shown to interact with other proteins such as LMO4,{{cite journal |last=Sutherland |first=Kate D |author2=Visvader Jane E |author3=Choong David Y H |author4=Sum Eleanor Y M |author5=Lindeman Geoffrey J |author6=Campbell Ian G |date=Oct 2003 |title=Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas |journal=Int. J. Cancer |volume=107 |issue=1 |pages=155–8 | issn = 0020-7136| pmid = 12925972 |doi = 10.1002/ijc.11343 |s2cid=20908722 |doi-access=free }}{{cite journal |last=Deane |first=Janet E |author2=Mackay Joel P |author3=Kwan Ann H Y |author4=Sum Eleanor Y M |author5=Visvader Jane E |author6=Matthews Jacqueline M |date=May 2003 |title=Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4 |journal=EMBO J. |volume=22 |issue=9 |pages=2224–33 | issn = 0261-4189| pmid = 12727888 |doi = 10.1093/emboj/cdg196 |pmc=156068 }} TCF3,{{cite journal |last=Goardon |first=Nicolas |author2=Lambert Julie A |author3=Rodriguez Patrick |author4=Nissaire Philippe |author5=Herblot Sabine |author6=Thibault Pierre |author7=Dumenil Dominique |author8=Strouboulis John |author9=Romeo Paul-Henri |author10=Hoang Trang |date=Jan 2006 |title=ETO2 coordinates cellular proliferation and differentiation during erythropoiesis |journal=EMBO J. |volume=25 |issue=2 |pages=357–66 | issn = 0261-4189| pmid = 16407974 |doi = 10.1038/sj.emboj.7600934 |pmc=1383517 }} TAL1 and CBFA2T3.

References

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Further reading

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  • {{cite journal |vauthors=Osada H, Grutz GG, Axelson H, etal |title=LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1. |journal=Leukemia |volume=11 |pages= 307–12 |year= 1997 |issue=Suppl 3 |pmid= 9209374 }}
  • {{cite journal |vauthors=Wadman IA, Osada H, Grütz GG, etal |title=The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3145–57 |year= 1997 |pmid= 9214632 |doi= 10.1093/emboj/16.11.3145 | pmc=1169933 }}
  • {{cite journal |vauthors=Jurata LW, Gill GN |title=Functional analysis of the nuclear LIM domain interactor NLI. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 5688–98 |year= 1997 |pmid= 9315627 |doi= 10.1128/MCB.17.10.5688| pmc=232417 }}
  • {{cite journal |vauthors=Visvader JE, Mao X, Fujiwara Y, etal |title=The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13707–12 |year= 1998 |pmid= 9391090 |doi=10.1073/pnas.94.25.13707 | pmc=28370 |bibcode=1997PNAS...9413707V |doi-access=free }}
  • {{cite journal |vauthors=Jurata LW, Pfaff SL, Gill GN |title=The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3152–7 |year= 1998 |pmid= 9452425 |doi=10.1074/jbc.273.6.3152 |doi-access=free }}
  • {{cite journal |vauthors=Kenny DA, Jurata LW, Saga Y, Gill GN |title=Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11257–62 |year= 1998 |pmid= 9736723 |doi=10.1073/pnas.95.19.11257 | pmc=21629 |bibcode=1998PNAS...9511257K |doi-access=free }}
  • {{cite journal |vauthors=Valge-Archer V, Forster A, Rabbitts TH |title=The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). |journal=Oncogene |volume=17 |issue= 24 |pages= 3199–202 |year= 1999 |pmid= 9872335 |doi= 10.1038/sj.onc.1202353 |s2cid=9835264 |doi-access= }}
  • {{cite journal |vauthors=Ueki N, Seki N, Yano K, etal |title=Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2. |journal=J. Hum. Genet. |volume=44 |issue= 2 |pages= 112–5 |year= 1999 |pmid= 10083735 |doi=10.1007/s100380050120 |doi-access=free }}
  • {{cite journal |vauthors=Drechsler M, Schumacher V, Friedrich S, etal |title=Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1–2 |pages= 119–24 |year= 2000 |pmid= 10640831 |doi=10.1159/000015377 |s2cid=23735189 }}
  • {{cite journal |vauthors=Dreyer SD, Morello R, German MS, etal |title=LMX1B transactivation and expression in nail-patella syndrome |journal=Hum. Mol. Genet. |volume=9 |issue= 7 |pages= 1067–74 |year= 2000 |pmid= 10767331 |doi=10.1093/hmg/9.7.1067 |doi-access=free }}
  • {{cite journal |vauthors=Sum EY, Peng B, Yu X, etal |title=The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7849–56 |year= 2002 |pmid= 11751867 |doi= 10.1074/jbc.M110603200 |doi-access= free }}
  • {{cite journal |vauthors=Ostendorff HP, Peirano RI, Peters MA, etal |title=Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors |journal=Nature |volume=416 |issue= 6876 |pages= 99–103 |year= 2002 |pmid= 11882901 |doi= 10.1038/416099a |bibcode=2002Natur.416...99O |s2cid=4426785 }}
  • {{cite journal |vauthors=Deane JE, Visvader JE, Mackay JP, Matthew JM |title=1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex |journal=J. Biomol. NMR |volume=23 |issue= 2 |pages= 165–6 |year= 2003 |pmid= 12153047 |doi=10.1023/A:1016363414644 |s2cid=30891765 }}
  • {{cite journal |vauthors=Chen L, Segal D, Hukriede NA, etal |title=Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 22 |pages= 14320–5 |year= 2002 |pmid= 12381786 |doi= 10.1073/pnas.212532399 | pmc=137882 |bibcode=2002PNAS...9914320C |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=van Meyel DJ, Thomas JB, Agulnick AD |title=Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo |journal=Development |volume=130 |issue= 9 |pages= 1915–25 |year= 2003 |pmid= 12642495 |doi=10.1242/dev.00389 |s2cid=6211268 |doi-access= }}
  • {{cite journal |vauthors=Deane JE, Mackay JP, Kwan AH, etal |title=Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4 |journal=EMBO J. |volume=22 |issue= 9 |pages= 2224–33 |year= 2003 |pmid= 12727888 |doi= 10.1093/emboj/cdg196 | pmc=156068 }}
  • {{cite journal |vauthors=Marini M, Bongers EM, Cusano R, etal |title=Confirmation of CLIM2/LMX1B interaction by yeast two-hybrid screening and analysis of its involvement in nail-patella syndrome |journal=Int. J. Mol. Med. |volume=12 |issue= 1 |pages= 79–82 |year= 2004 |pmid= 12792813 |doi= 10.3892/ijmm.12.1.79}}

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