Login
Login

LSU rRNA

{{Short description|One of the two major RNA components of the ribosome}}

{{missing information|structure (universal)|date=December 2020}}

Large subunit ribosomal ribonucleic acid (LSU rRNA) is the largest of the two major RNA components of the ribosome.

Associated with a number of ribosomal proteins, the LSU rRNA forms the large subunit of the ribosome.

The LSU rRNA acts as a ribozyme, catalyzing peptide bond formation.

{{Infobox rfam

| Symbol = LSU

| Rfam_clan = CL00112

}}

Characteristics

class="wikitable sortable" style="text-align: center;"

|+ Characteristics of the LSU rRNA for exemplary species.

!Type

!LSU rRNA size

!Species

!Length

!Accession

!Reference

Bacterial (Prokaryotic)

| 23S

| Escherichia coli

| 2,905 nt

| NR_076322.1

| {{cite web | url = https://www.ncbi.nlm.nih.gov/nuccore/NR_076322.1 | title= Escherichia coli 23S ribosomal RNA | date= 3 February 2015 }}

Archaeal (Prokaryotic)

| 23S

| Halobacterium salinarum

| 2,906 nt

| NR_076247.1

| {{cite web | url = https://www.ncbi.nlm.nih.gov/nuccore/NR_076247.1 | title= Halobacterium salinarum 23S ribosomal RNA | date= 3 February 2015 }}

Eukaryotic

| 5.8S & 28S

| Homo sapiens

| 157 + 5,025 nt

| NR_145821.1; M11167.1

| {{cite web |title=Homo sapiens RNA, 5.8S ribosomal N1 (RNA5-8SN1), ribosomal RNA |url=https://www.ncbi.nlm.nih.gov/nuccore/NR_145821.1 |date=3 July 2020}}{{cite web | url = https://www.ncbi.nlm.nih.gov/nuccore/M11167.1 | title= Homo sapiens 28S ribosomal RNA (nuclear) | date= 10 November 1986 }}

Mitochondrial

| 16S

| Homo sapiens

| 1,559 nt

| NC_012920.1

| Homo sapiens mitochondrion, complete genome. [https://www.ncbi.nlm.nih.gov/nuccore/NC_012920.1 "Revised Cambridge Reference Sequence (rCRS): accession NC_012920"], National Center for Biotechnology Information. Retrieved on 20 February 2017.{{cite journal | vauthors = Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG | title = Sequence and organization of the human mitochondrial genome | journal = Nature | volume = 290 | issue = 5806 | pages = 457–465 | date = April 1981 | pmid = 7219534 | doi = 10.1038/290457a0 | bibcode = 1981Natur.290..457A }}

Plastid

| 23S

| Arabidopsis thaliana

| 2,810 nt

| NC_000932.1

| {{cite web | url = https://www.ncbi.nlm.nih.gov/nuccore/NC_000932.1 | title= Arabidopsis thaliana 23S ribosomal RNA (chloroplast) | date= 3 April 2023 }}

Use in phylogenetics

LSU rRNA sequences are widely used for working out evolutionary relationships among organisms, since they are of ancient origin and are found in all known forms of life.

See also

  • SSU rRNA: the small subunit ribosomal ribonucleic acid.

References

{{reflist}}

{{ribosome subunits}}

Category:Ribosomal RNA

Category:Protein biosynthesis