MT-RNR2

{{Short description|Human gene}}

{{infobox protein

|Name=mitochondrially encoded 16S RNA

|caption=

|image=

|width=

|HGNCid=7471

|Symbol=MT-RNR2

|AltSymbols=MTRNR2

|EntrezGene= 4550

|OMIM=

|RefSeq=

|UniProt= Q8IVG9

|PDB=

|ECnumber=

|Chromosome=MT

|Arm=

|Band=

|LocusSupplementaryData=

}}

File:Map of the human mitochondrial genome.svg

Mitochondrially encoded 16S RNA (often abbreviated as 16S) is the mitochondrial large subunit ribosomal RNA{{cite journal | vauthors = Noda R, Kim CG, Takenaka O, Ferrell RE, Tanoue T, Hayasaka I, Ueda S, Ishida T, Saitou N | display-authors = 6 | title = Mitochondrial 16S rRNA sequence diversity of hominoids | journal = The Journal of Heredity | volume = 92 | issue = 6 | pages = 490–496 | year = 2001 | pmid = 11948216 | doi = 10.1093/jhered/92.6.490 | doi-access = free }}{{cite journal | vauthors = Nagy A, Wilhelm M, Kovacs G | title = Mutations of mtDNA in renal cell tumours arising in end-stage renal disease | journal = The Journal of Pathology | volume = 199 | issue = 2 | pages = 237–242 | date = February 2003 | pmid = 12533837 | doi = 10.1002/path.1273 | s2cid = 35602546 }} that in humans is encoded by the MT-RNR2 gene. The MT-RNR2 gene also encodes the Humanin polypeptide that has been the target of Alzheimer's disease research.{{cite journal | vauthors = Tajima H, Niikura T, Hashimoto Y, Ito Y, Kita Y, Terashita K, Yamazaki K, Koto A, Aiso S, Nishimoto I | display-authors = 6 | title = Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults | journal = Neuroscience Letters | volume = 324 | issue = 3 | pages = 227–231 | date = May 2002 | pmid = 12009529 | doi = 10.1016/S0304-3940(02)00199-4 | s2cid = 12088367 }}

The 16S rRNA is the mitochondrial homologue of the prokaryotic 23S and eukaryotic nuclear 28S ribosomal RNAs.{{cite journal | vauthors = Eperon IC, Anderson S, Nierlich DP | title = Distinctive sequence of human mitochondrial ribosomal RNA genes | journal = Nature | volume = 286 | issue = 5772 | pages = 460–467 | date = July 1980 | pmid = 6157106 | doi = 10.1038/286460a0 | bibcode = 1980Natur.286..460E | s2cid = 4262269 }}