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LYL1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.{{cite journal | vauthors = Mellentin JD, Smith SD, Cleary ML | title = lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif | journal = Cell | volume = 58 | issue = 1 | pages = 77–83 | date = July 1989 | pmid = 2752424 | doi = 10.1016/0092-8674(89)90404-2 | s2cid = 24737263 }}{{cite web | title = Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4066}}

Interactions

LYL1 has been shown to interact with TCF3{{cite journal | vauthors = Miyamoto A, Cui X, Naumovski L, Cleary ML | title = Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells | journal = Molecular and Cellular Biology | volume = 16 | issue = 5 | pages = 2394–401 | date = May 1996 | pmid = 8628307 | pmc = 231228 | doi = 10.1128/mcb.16.5.2394 }} and NFKB1.{{cite journal | vauthors = Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D | title = Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105 | journal = Oncogene | volume = 18 | issue = 4 | pages = 995–1005 | date = January 1999 | pmid = 10023675 | doi = 10.1038/sj.onc.1202374 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ | title = TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 24 | pages = 11416–20 | date = December 1991 | pmid = 1763056 | pmc = 53146 | doi = 10.1073/pnas.88.24.11416 | bibcode = 1991PNAS...8811416X | doi-access = free }}
  • {{cite journal | vauthors = Kuo SS, Mellentin JD, Copeland NG, Gilbert DJ, Jenkins NA, Cleary ML | title = Structure, chromosome mapping, and expression of the mouse Lyl-1 gene | journal = Oncogene | volume = 6 | issue = 6 | pages = 961–8 | date = June 1991 | pmid = 2067848 }}
  • {{cite journal | vauthors = Saltman DL, Mellentin JD, Smith SD, Cleary ML | title = Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization | journal = Genes, Chromosomes & Cancer | volume = 2 | issue = 4 | pages = 259–65 | date = November 1990 | pmid = 2268576 | doi = 10.1002/gcc.2870020402 | s2cid = 103922 }}
  • {{cite journal | vauthors = Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R | title = Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia | journal = The EMBO Journal | volume = 13 | issue = 20 | pages = 4831–9 | date = October 1994 | pmid = 7957052 | pmc = 395422 | doi = 10.1002/j.1460-2075.1994.tb06809.x}}
  • {{cite journal | vauthors = Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A | title = Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers | journal = Genomics | volume = 15 | issue = 1 | pages = 133–45 | date = January 1993 | pmid = 8432525 | doi = 10.1006/geno.1993.1021 | url = https://zenodo.org/record/1229582 }}
  • {{cite journal | vauthors = Miyamoto A, Cui X, Naumovski L, Cleary ML | title = Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells | journal = Molecular and Cellular Biology | volume = 16 | issue = 5 | pages = 2394–401 | date = May 1996 | pmid = 8628307 | pmc = 231228 | doi = 10.1128/mcb.16.5.2394 }}
  • {{cite journal | vauthors = Mahajan MA, Park ST, Sun XH | title = Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins | journal = Oncogene | volume = 12 | issue = 11 | pages = 2343–50 | date = June 1996 | pmid = 8649774 }}
  • {{cite journal | vauthors = Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D | title = Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105 | journal = Oncogene | volume = 18 | issue = 4 | pages = 995–1005 | date = January 1999 | pmid = 10023675 | doi = 10.1038/sj.onc.1202374 | doi-access = free }}
  • {{cite journal | vauthors = Meng YS, Khoury H, Dick JE, Minden MD | title = Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia | journal = Leukemia | volume = 19 | issue = 11 | pages = 1941–7 | date = November 2005 | pmid = 16094422 | doi = 10.1038/sj.leu.2403836 | doi-access = free }}

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External links

  • {{MeshName|LYL1+protein,+human}}

{{Transcription factors|g1}}

Category:Transcription factors

{{gene-19-stub}}