NFKB1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.{{cite journal | vauthors = Meyer R, Hatada EN, Hohmann HP, Haiker M, Bartsch C, Röthlisberger U, Lahm HW, Schlaeger EJ, van Loon AP, Scheidereit C | title = Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 3 | pages = 966–70 | date = March 1991 | pmid = 1992489 | pmc = 50935 | doi = 10.1073/pnas.88.3.966 | bibcode = 1991PNAS...88..966M | doi-access = free }}

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex. NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.{{cite web | title = Entrez Gene: NF-κB nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4790}}

Interactions

NFKB1 has been shown to interact with:

BCL3,{{cite journal | vauthors = Thornburg NJ, Pathmanathan R, Raab-Traub N | title = Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma | journal = Cancer Res. | volume = 63 | issue = 23 | pages = 8293–301 | date = December 2003 | pmid = 14678988 }}{{cite journal | vauthors = Naumann M, Wulczyn FG, Scheidereit C | title = The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B | journal = EMBO J. | volume = 12 | issue = 1 | pages = 213–22 | date = January 1993 | pmid = 8428580 | pmc = 413194 | doi = 10.1002/j.1460-2075.1993.tb05647.x}}
C22orf25,
HDAC1,{{cite journal | vauthors = Zhong H, May MJ, Jimi E, Ghosh S | title = The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1 | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 625–36 | date = March 2002 | pmid = 11931769 | doi = 10.1016/s1097-2765(02)00477-x| doi-access = free }}
HMGA2{{cite journal | vauthors = Noro B, Licheri B, Sgarra R, Rustighi A, Tessari MA, Chau KY, Ono SJ, Giancotti V, Manfioletti G | title = Molecular dissection of the architectural transcription factor HMGA2 | journal = Biochemistry | volume = 42 | issue = 15 | pages = 4569–77 | date = April 2003 | pmid = 12693954 | doi = 10.1021/bi026605k | s2cid = 39605320 }}
IKK2,{{cite journal | vauthors = Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C | title = NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes | journal = EMBO J. | volume = 18 | issue = 17 | pages = 4766–78 | date = September 1999 | pmid = 10469655 | pmc = 1171549 | doi = 10.1093/emboj/18.17.4766 }}{{cite journal | vauthors = Heissmeyer V, Krappmann D, Hatada EN, Scheidereit C | title = Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha | journal = Mol. Cell. Biol. | volume = 21 | issue = 4 | pages = 1024–35 | date = February 2001 | pmid = 11158290 | pmc = 99557 | doi = 10.1128/MCB.21.4.1024-1035.2001 }}
ITGB3BP,{{cite journal | vauthors = Besta F, Massberg S, Brand K, Müller E, Page S, Grüner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M | title = Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor | journal = J. Cell Sci. | volume = 115 | issue = Pt 20 | pages = 3879–88 | date = October 2002 | pmid = 12244126 | doi = 10.1242/jcs.00081| doi-access = free }}
IκBα,{{cite journal | vauthors = Hay DC, Kemp GD, Dargemont C, Hay RT | title = Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription | journal = Mol. Cell. Biol. | volume = 21 | issue = 10 | pages = 3482–90 | date = May 2001 | pmid = 11313474 | pmc = 100270 | doi = 10.1128/MCB.21.10.3482-3490.2001 }}{{cite journal | vauthors = Malek S, Huxford T, Ghosh G | title = Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB | journal = J. Biol. Chem. | volume = 273 | issue = 39 | pages = 25427–35 | date = September 1998 | pmid = 9738011 | doi = 10.1074/jbc.273.39.25427| doi-access = free }}
LYL1,{{cite journal | vauthors = Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D | title = Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105 | journal = Oncogene | volume = 18 | issue = 4 | pages = 995–1005 | date = January 1999 | pmid = 10023675 | doi = 10.1038/sj.onc.1202374 | doi-access = free }}
MAP3K7IP2,{{cite journal | vauthors = Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG | title = Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein | journal = Cell | volume = 110 | issue = 1 | pages = 55–67 | date = July 2002 | pmid = 12150997 | doi = 10.1016/S0092-8674(02)00809-7| s2cid = 17679498 | doi-access = free }}
MAP3K8,{{cite journal | vauthors = Belich MP, Salmerón A, Johnston LH, Ley SC | title = TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105 | journal = Nature | volume = 397 | issue = 6717 | pages = 363–8 | date = January 1999 | pmid = 9950430 | doi = 10.1038/16946 | bibcode = 1999Natur.397..363B | s2cid = 4391108 }}
MEN1,{{cite journal | vauthors = Heppner C, Bilimoria KY, Agarwal SK, Kester M, Whitty LJ, Guru SC, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ, Burns AL | title = The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation | journal = Oncogene | volume = 20 | issue = 36 | pages = 4917–25 | date = August 2001 | pmid = 11526476 | doi = 10.1038/sj.onc.1204529 | doi-access = free }}
NFKB2,{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 | s2cid = 11683986 }}
NFKBIE,{{cite journal | vauthors = Li Z, Nabel GJ | title = A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription | journal = Mol. Cell. Biol. | volume = 17 | issue = 10 | pages = 6184–90 | date = October 1997 | pmid = 9315679 | pmc = 232469 | doi = 10.1128/mcb.17.10.6184}}
NOTCH1,{{cite journal | vauthors = Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T | title = T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells | journal = J. Exp. Med. | volume = 183 | issue = 5 | pages = 2025–32 | date = May 1996 | pmid = 8642313 | pmc = 2192574 | doi = 10.1084/jem.183.5.2025}}{{cite journal | vauthors = Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E | title = Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain | journal = J. Immunol. | volume = 167 | issue = 1 | pages = 289–95 | date = July 2001 | pmid = 11418662 | doi = 10.4049/jimmunol.167.1.289| doi-access = free }}
Nuclear receptor coactivator 1,{{cite journal | vauthors = Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW | title = Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2 | journal = Mol. Endocrinol. | volume = 14 | issue = 6 | pages = 915–25 | date = June 2000 | pmid = 10847592 | doi = 10.1210/mend.14.6.0471 | doi-access = free }}{{cite journal | vauthors = Na SY, Lee SK, Han SJ, Choi HS, Im SY, Lee JW | title = Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations | journal = J. Biol. Chem. | volume = 273 | issue = 18 | pages = 10831–4 | date = May 1998 | pmid = 9556555 | doi = 10.1074/jbc.273.18.10831| doi-access = free }}
RELA,{{cite journal | vauthors = Palvimo JJ, Reinikainen P, Ikonen T, Kallio PJ, Moilanen A, Jänne OA | title = Mutual transcriptional interference between RelA and androgen receptor | journal = J. Biol. Chem. | volume = 271 | issue = 39 | pages = 24151–6 | date = September 1996 | pmid = 8798655 | doi = 10.1074/jbc.271.39.24151| doi-access = free }}
RELB,
STAT3,{{cite journal | vauthors = Yu Z, Zhang W, Kone BC | title = Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB | journal = Biochem. J. | volume = 367 | issue = Pt 1 | pages = 97–105 | date = October 2002 | pmid = 12057007 | pmc = 1222853 | doi = 10.1042/BJ20020588 }}
STAT6,{{cite journal | vauthors = Shen CH, Stavnezer J | title = Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription | journal = Mol. Cell. Biol. | volume = 18 | issue = 6 | pages = 3395–404 | date = June 1998 | pmid = 9584180 | pmc = 108921 | doi = 10.1128/mcb.18.6.3395}} and
TSC22D3.{{cite journal | vauthors = Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C | title = Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB | journal = Blood | volume = 98 | issue = 3 | pages = 743–53 | date = August 2001 | pmid = 11468175 | doi = 10.1182/blood.v98.3.743| doi-access = free }}

References

External links

{{MeshName|NFKB1+protein,+human}}
{{FactorBook|NFKB}}

Category:Transcription factors

Category:Genes mutated in mice

NFKB1

Interactions

References

Further reading

External links