Leukocyte receptor tyrosine kinase

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.{{cite journal | vauthors = Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, Delfino-Machín M, Haffter P, Geisler R, Johnson SL, Ward A, Kelsh RN | title = Leukocyte tyrosine kinase functions in pigment cell development | journal = PLOS Genet. | volume = 4 | issue = 3 | pages = e1000026 | year = 2008 | pmid = 18369445 | pmc = 2265441 | doi = 10.1371/journal.pgen.1000026 | doi-access = free }} Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

LTK has been shown to interact with IRS-1, Shc, and PIK3R1.{{cite journal | vauthors = Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H | title = Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo | journal = Oncogene | volume = 9 | issue = 10 | pages = 2991–8 | date = October 1994 | pmid = 8084603 }}{{cite journal | vauthors = Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H | title = The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase | journal = Oncogene | volume = 14 | issue = 25 | pages = 3067–72 | date = June 1997 | pmid = 9223670 | doi = 10.1038/sj.onc.1201153 | doi-access = free }}

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• {{cite journal | vauthors = Krolewski JJ, Dalla-Favera R | title = The ltk gene encodes a novel receptor-type protein tyrosine kinase. | journal = EMBO J. | volume = 10 | issue = 10 | pages = 2911–9 | year = 1991 | doi = 10.1002/j.1460-2075.1991.tb07841.x | pmid = 1655406 | pmc = 453005 }}
• {{cite journal | vauthors = Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R | title = Identification and chromosomal mapping of new human tyrosine kinase genes. | journal = Oncogene | volume = 5 | issue = 3 | pages = 277–82 | year = 1990 | pmid = 2156206 }}
• {{cite journal | vauthors = Ben-Neriah Y, Bauskin AR | title = Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain. | journal = Nature | volume = 333 | issue = 6174 | pages = 672–6 | year = 1988 | pmid = 2836739 | doi = 10.1038/333672a0 | bibcode = 1988Natur.333..672B | s2cid = 4262549 }}
• {{cite journal | vauthors = Toyoshima H, Kozutsumi H, Maru Y, Hagiwara K, Furuya A, Mioh H, Hanai N, Takaku F, Yazaki Y, Hirai H | title = Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 12 | pages = 5404–8 | year = 1993 | pmid = 7685902 | pmc = 46728 | doi = 10.1073/pnas.90.12.5404 | bibcode = 1993PNAS...90.5404T | doi-access = free }}
• {{cite journal | vauthors = Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C | title = Regional localization of human chromosome 15 loci. | journal = Genomics | volume = 23 | issue = 3 | pages = 619–27 | year = 1995 | pmid = 7851890 | doi = 10.1006/geno.1994.1550 }}
• {{cite journal | vauthors = Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H | title = Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. | journal = Oncogene | volume = 9 | issue = 10 | pages = 2991–8 | year = 1994 | pmid = 8084603 }}
• {{cite journal | vauthors = Kozutsumi H, Toyoshima H, Hagiwara K, Furuya A, Mioh H, Hanai N, Yazaki Y, Hirai H | title = Identification of the human ltk gene product in placenta and hematopoietic cell lines. | journal = Biochem. Biophys. Res. Commun. | volume = 190 | issue = 2 | pages = 674–9 | year = 1993 | pmid = 8427607 | doi = 10.1006/bbrc.1993.1101 }}
• {{cite journal | vauthors = Ueno H, Sasaki K, Kozutsumi H, Miyagawa K, Mitani K, Yazaki Y, Hirai H | title = Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. | journal = J. Biol. Chem. | volume = 271 | issue = 44 | pages = 27707–14 | year = 1996 | pmid = 8910363 | doi = 10.1074/jbc.271.44.27707 | doi-access = free }}
• {{cite journal | vauthors = Snijders AJ, Ho SC, Haase VH, Pillai S, Bernards A | title = A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin. | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1297–301 | year = 1997 | pmid = 8995435 | doi = 10.1074/jbc.272.2.1297 | doi-access = free }}
• {{cite journal | vauthors = Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H | title = The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. | journal = Oncogene | volume = 14 | issue = 25 | pages = 3067–72 | year = 1997 | pmid = 9223670 | doi = 10.1038/sj.onc.1201153 | doi-access = free }}
• {{cite journal | vauthors = Espanel X, Huguenin-Reggiani M, Hooft van Huijsduijnen R | title = The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities. | journal = Protein Sci. | volume = 11 | issue = 10 | pages = 2326–34 | year = 2003 | pmid = 12237455 | pmc = 2373693 | doi = 10.1110/ps.0213402 }}
• {{cite journal | vauthors = Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S | title = Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. | journal = Hum. Mol. Genet. | volume = 13 | issue = 2 | pages = 171–9 | year = 2004 | pmid = 14695357 | doi = 10.1093/hmg/ddh020 | doi-access = free }}

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{{Tyrosine kinases}}

{{Enzymes}}

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Category:Tyrosine kinase receptors

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