List of Doctors characters introduced in 2022#DS Matt Cassidy

! scope="col" | Episode date(s)

! scope="col" | Actor

! scope="col" | Circumstances

| {{nowrap|17–27 January}}

| {{nowrap|Bobby Wilkinson}}

| A patient of Daniel Granger's (Matthew Chambers) who has been suffering from stomach pain for seven years. Daniel prescribes her painkillers but a day later, she suffers from sharp stomach pains. Emma Reid (Dido Miles) examines her and realises that she could have endometriosis. After she is admitted to hospital, Daniel visits her to which she expresses her disgust with how he has treated her.

| rowspan="3" | 17 January

| Fidel Nanton

| A diversity activist and motivational speaker working at St. Phils Hospital. Zebbie Hart (Carlyss Peer), his apprentice, exposes him for making numerous sexually inappropriate comments and trying to sexually assault her.

| Carlyss Peer

| Bear Sylvester's (Dex Lee) friend who exposes Francis Peyton (Fidel Nanton), Bear's idol, for making numerous sexually inappropriate comments and trying to sexually assault her.

| Karen Ascoe

| An employee at St. Phils Hospital who deals with Bear Sylvester's (Lee) complaints about the hospital's staff.

| {{nowrap|18 January–2 February}}

| Sophie Kandola{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Ruhma Carter has a NEW houseguest! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-ruhma-carter-has-a-new-houseguest |access-date=18 January 2022 |work=What to Watch |publisher=(Future plc) |archive-date=18 January 2022 |archive-url=https://web.archive.org/web/20220118204411/https://www.whattowatch.com/spoilers/doctors-spoilers-ruhma-carter-has-a-new-houseguest |url-status=live }}

| Hazeem Durrani's (Ashraf Ejjbair) romantic partner from his travels in Thailand. Despite the pair having a casual relationship, she tracks him down at Ruhma Carter's (Bharti Patel) house and stays with him there due to her broken relationship with her parents. Daisha and Ruhma become close, but after Hazeem dumps Daisha, he insists the pair cut contact.

| rowspan="2" | 18 January

| {{nowrap|Jordan Gallagher}}

| The partner of Shayla Moore (Thea Collins) who gets an infected cyst surgically removed by Sid Vere (Ashley Rice) so that himself and Shayla can visit the northern lights.

| Thea Collins

| Jackson Tweed's (Jordan Gallagher) pregnant partner who wishes to visit the northern lights with him to give birth to their child.

| rowspan="2" | 19 January

| Hugh Simon{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Sid Vere investigates a FATAL accident |url=https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-investigates-a-fatal-accident |access-date=19 January 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 January 2022 |archive-url=https://web.archive.org/web/20220120142203/https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-investigates-a-fatal-accident |url-status=live }}

| An elderly man who admits to killing his son.

| Ione Brown

| A police sergeant who arrests Adrian Walker (Hugh Simon) under suspicion of killing his son.

| {{nowrap|20 January–8 February}}

| Andrew Macklin{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Can Karen and Rob Hollins solve a MYSTERY? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-karen-and-rob-hollins-solve-a-mystery |access-date=20 January 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 January 2022 |archive-url=https://web.archive.org/web/20220120142202/https://www.whattowatch.com/spoilers/doctors-spoilers-can-karen-and-rob-hollins-solve-a-mystery |url-status=live }}

| A patient of Jimmi Clay's (Adrian Lewis Morgan) who suffers from social anxiety and depression. After he loses his job and breaks up with Rachelle Thomas (Ellie Nunn), he kills himself.

| rowspan="4" | 20 January

| Miranda Nolan

| A woman with inverted nipples who has a long-term fear of dating men due to a man once reacting badly to seeing her naked.

| Jeryl Burgess

| The mother of Olivia (Miranda Nolan) who sees Al Haskey (Ian Midlane) about her incontinence.

| Jamie Pigott

| Olivia Franklin's (Nolan) gardener who rejects her invitation to go on a date.

| Fiz Marcus

| A homeless woman who steals Karen Hollins' (Jan Pearson) handbag.

| rowspan="3" | 24 January

| Badger Skelton{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Zara Carmichael and Emma's FEUD continues! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-zara-carmichael-and-emmas-feud-continues |access-date=24 January 2022 |work=What to Watch |publisher=(Future plc) |archive-date=24 January 2022 |archive-url=https://web.archive.org/web/20220124220128/https://www.whattowatch.com/spoilers/doctors-spoilers-zara-carmichael-and-emmas-feud-continues |url-status=live }}

| A teenager who was abducted by Kenny Coles (Nick Cochrane) at a young age.

| Nick Cochrane

| A criminal who abducted Josh Coles (Badger Skelton) at a young age and led him into a life of crime.

| Katie Grace

| The mother of Josh Coles (Skelton) who is reunited with him several years after he has been abducted by Kenny Coles (Cochrane).

| rowspan="2" | 25 January

| {{nowrap|Kianyah Caesar-Downer{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Meet NEW nurse Fiona Worth! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-meet-new-nurse-fiona-worth |access-date=27 January 2022 |work=What to Watch |publisher=(Future plc) |archive-date=27 January 2022 |archive-url=https://web.archive.org/web/20220127163820/https://www.whattowatch.com/spoilers/doctors-spoilers-meet-new-nurse-fiona-worth |url-status=live }}}}

| A temporary nurse hired by Bear Sylvester (Lee) to cover for Tash Verma (Maria Pike).

| Bella Hamblin

| A woman who calls in to Emma Reid's (Miles) radio show to talk about a male doctor misdiagnosing a condition concerning her reproductive system.

| rowspan="3" | 26 January

| Hannah Raynor{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Al Haskey hosts a roleplaying game! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-hosts-a-roleplaying-game |access-date=27 January 2022 |work=What to Watch |publisher=(Future plc) |archive-date=27 January 2022 |archive-url=https://web.archive.org/web/20220127163822/https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-hosts-a-roleplaying-game |url-status=live }}

| rowspan="3" | Three players of Al Haskey's (Midlane) roleplaying game that provides mental health benefits to the players.

| Ben Rufus Green

| Deven Modha

| rowspan="3" | 27 January

| {{nowrap|Nicola Stuart-Hill{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHY is Zara Carmichael on the warpath? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-zara-carmichael-on-the-warpath |access-date=27 January 2022 |work=What to Watch |publisher=(Future plc) |archive-date=27 January 2022 |archive-url=https://web.archive.org/web/20220127163821/https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-zara-carmichael-on-the-warpath |url-status=live }}}}

| A former teacher who lost her job after Jamie Renton (Jonny Labey) lied by telling people they had sex. Losing her job made Charlotte become addicted to drugs and homeless, a lifestyle she manages to become clean from after ten years.

| Alisha Williams

| The girlfriend of Jamie Renton (Labey).

| Jonny Labey

| A former student of Charlotte Whitby (Nicola Stuart-Hill) who lied by stating that the pair had sex.

| {{nowrap|31 January–8 February}}

| Ellie Nunn{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Daisha Rashid is HEARTBROKEN over Hazeem... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-daisha-rashid-is-heartbroken-over-hazeem |access-date=4 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=3 March 2022 |archive-url=https://web.archive.org/web/20220303202357/https://www.whattowatch.com/spoilers/doctors-spoilers-daisha-rashid-is-heartbroken-over-hazeem |url-status=live }}

| The girlfriend of Tim Watkins (Andrew Macklin), who is suffering from depression. She attends a counselling session with him, and despite agreeing that their situation can improve, she later calls her mother and says she is miserable in their relationship.

| rowspan="2" | 31 January

| Phillipa Peak

| The controlling mother of Talia (Emily Redpath) who convinces herself that Talia has an eating disorder. She is later corrected by Sid Vere (Rice), who informs her that she may have Chron's disease.

| Emily Redpath

| The daughter of Carol (Phillipa Peak) who is convinced that Talia has an eating disorder. After sneaking away from Carol to a consultation with Sid Vere (Rice), he suggests that she may have Chron's disease.

| {{nowrap|1–7 February}}

| Zora Bishop{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHY does Zara Carmichael annoy Jimmi? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-why-does-zara-carmichael-annoy-jimmi |access-date=4 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=4 February 2022 |archive-url=https://web.archive.org/web/20220204234328/https://www.whattowatch.com/spoilers/doctors-spoilers-why-does-zara-carmichael-annoy-jimmi |url-status=live }}

| A sergeant at Letherbridge Police Station who shows Zara Carmichael (Elisabeth Dermot Walsh) shows around in the hopes of her becoming an FME.

| rowspan="2" | 1 February

| Connor Byrne

| A man whose wife died. He is judged by his son, Tom (Harry Rundle)

| Harry Rundle

| The son of Dale (Connor Byrne) who struggles to cope with his grief for his dead mother.

| rowspan="2" | 2 February

| Julia Hills{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Emma Reid confronts Zara... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-emma-reid-confronts-zara |access-date=4 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=4 February 2022 |archive-url=https://web.archive.org/web/20220204234326/https://www.whattowatch.com/spoilers/doctors-spoilers-emma-reid-confronts-zara |url-status=live }}

| Bear Sylvester's (Lee) neighbour who is shocked to find her son, Felix (Ben Rose), dealing drugs on their street.

| Ben Rose

| A drug dealer who is arrested by PC Pat Dyson (Dawn Butler).

| rowspan="2" | 3 February

| Alan Drake{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: DANGER for Zara Carmichael! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-danger-for-zara-carmichael |access-date=4 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=4 February 2022 |archive-url=https://web.archive.org/web/20220204234325/https://www.whattowatch.com/spoilers/doctors-spoilers-danger-for-zara-carmichael |url-status=live }}

| Zara Carmichael's (Walsh) patient who suffers from severe anxiety and psychosis. He believes that he is dating Zara and traps her in his house.

| {{nowrap|Joyce Omotola}}

| A police call handler who receives a call from Zara Carmichael (Walsh). As she is unable to speak openly due to being in danger, she dials 55 on the phone. This alerts Rakie that the call is a Silent Solution call and she helps Zara to get help.

| rowspan="3" | 8 February

| {{nowrap|Nicola Jayne Ingram{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHO tries to end Emma and Zara's feud? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-tries-to-end-emma-and-zaras-feud |access-date=8 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=8 February 2022 |archive-url=https://web.archive.org/web/20220208154743/https://www.whattowatch.com/spoilers/doctors-spoilers-who-tries-to-end-emma-and-zaras-feud |url-status=live }}}}

| Sid Vere's (Rice) colleague who

| Alim Jayda

| A homeless man who is attacked by Rhodes Davis (James Thackeray).

| James Thackeray

| A vigilante who attacks homeless people. He tries to attack Sid Vere (Rice) until interrupted by Sid's colleague, Yaz Roper (Nicola Jayne Ingram).

| rowspan="2" | 8 February

| Mitchell Hunt{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHO does Zara Carmichael reconnect with? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-zara-carmichael-reconnect-with |access-date=8 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=8 February 2022 |archive-url=https://web.archive.org/web/20220208154744/https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-zara-carmichael-reconnect-with |url-status=live }}

| Tim Watkins' (Macklin) former boss who fired him due to his mental illnesses.

| Marcia Lecky

| A worker from the mental health crisis team who checks up on Tim Watkins (Macklin) prior to his suicide.

| rowspan="2" | 9 February

| {{nowrap|Stephanie Fayerman}}

| An elderly woman who accidentally calls paramedics to her home whilst asleep.

| Portia Booroff

| Shona's (Stephanie Fayerman) sister who commits to supporting her more.

| rowspan="3" | 10 February

| Matthew Carver

| A patient of Al Haskey's (Midlane) who is being pushed to sell drugs in his flat owned by Haweswood Housing. Al escalates his issue to company director Paul Tasak (Hugo Salter).

| Tommy Oldroyd

| Neil Hirst's (Matthew Carver) flatmate who encourages him to deal drugs.

| Hugo Salter

| The director of Haweswood Housing who ignored that several of the flats he rents out are in terrible condition.

| rowspan="2" | 14 February

| Felicity Dean{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Can Al Haskey stop Jimmi from QUITTING? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-al-haskey-stop-jimmi-from-quitting |access-date=20 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 February 2022 |archive-url=https://web.archive.org/web/20220220210537/https://www.whattowatch.com/spoilers/doctors-spoilers-can-al-haskey-stop-jimmi-from-quitting |url-status=live }}

| A friend of Daniel Granger's (Chambers) who has a crush on Robert Barnes (Neil Caple). Daniel helps to bring them together.

| Neil Caple

| A gardener who goes on a date with Barbara Hopkins (Felicity Dean).

| rowspan="4" | 15 February

| Jalleh Alexander{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Can Rob and Karen Hollins save a life? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-rob-and-karen-hollins-save-a-life |access-date=20 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 February 2022 |archive-url=https://web.archive.org/web/20220220210535/https://www.whattowatch.com/spoilers/doctors-spoilers-can-rob-and-karen-hollins-save-a-life |url-status=live }}

| A police officer who helps Rob Hollins (Chris Walker) with a case concerning an endangered child.

| Annabel Brook

| A child who calls the Mill to inform them that her mother is unconscious and laying in her own blood. She struggles to give information about her whereabouts to Rob Hollins (Walker), but he eventually helps the police to locate Bethany.

| Sean Connolly

| Bethany McAllister's (Annabel Brook) step-father.

| Sean Connolly

| A police call handler who helps to find Bethany McAllister (Brook).

| rowspan="3" | 16 February

| {{nowrap|Josephine Lloyd-Welcome}}

| The grandmother of Neha Kashif (Anoushka Chadha) who takes her to see Sid Vere (Rice) at the Mill due to worrying about her following the death of Neha's mother.

| Anoushka Chadha

| A teenager who, after the death of her mother, pulls her hair out and eats it.

| Eliza Smith

| Neha Kashif's (Chadha) friend who encourages her to see a doctor.

| rowspan="2" | 17 February

| {{nowrap|Henry Douthwaite}}

| Davinia's (Clare Wille) husband from London who surprises her by randomly arriving at Zara Carmichael's (Walsh) house.

| Michelle Connolly

| A patient of Ruhma Carter's (Patel) who has suffered a miscarriage.

| rowspan="3" | 21 February

| Mariah Louca{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Daniel Granger has a WARNING for Zara! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-has-a-warning-for-zara |access-date=21 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=21 February 2022 |archive-url=https://web.archive.org/web/20220221225853/https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-has-a-warning-for-zara |url-status=live }}

| A friend of Emma Reid's (Miles) who comes out as a trans woman. She receives transphobic comments from colleague Lucy Palmer (Sarah Jayne-Butler), who is fired by manager Verity Foster (Jane Gurnett).

| Jane Gurnett

| The manager of a funeral home who fires Lucy Palmer (Jayne-Butler) for transphobic comments she makes to Suzanne Towers (Mariah Luca).

| {{nowrap|Sarah Jayne-Butler}}

| A staff member at a funeral home who is fired for making transphobic comments to Suzanne Towers (Louca).

| rowspan="4" | 22 February

| Scott Hinds

| A man with a brain tumour that, as a result, suffers from short and long-term memory loss.

| Charlotte Pyke

| The wife of Roland (Scott Hinds) who discovers that prior to him losing his memory, he had numerous affairs through various dating websites.

| Gemma Hepworth

| A woman who is contacted by Sindy Atlee (Charlotte Pyke) due to having a historic affair with her husband, Roland (Hinds).

| Emma Cooke

| An old classmate of Davinia Hargrove (Wille) and Zara Carmichael (Walsh). She says that she was always intimidated by the pair, and after Davinia nastily talks about times Belinda was humiliated at school, she leaves.

| {{nowrap|23 February–16 March}}

| Raj Paul{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHY does Jimmi Clay PANIC? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-why-does-jimmi-clay-panic |access-date=25 February 2022 |work=What to Watch |publisher=(Future plc) |archive-date=3 March 2022 |archive-url=https://web.archive.org/web/20220303202409/https://www.whattowatch.com/spoilers/doctors-spoilers-why-does-jimmi-clay-panic |url-status=live }}

| A patient of Jimmi Clay's (Morgan) suffering from depression and anxiety. Due to the lack of profit in his recording studio, he is forced to sell the building, which causes him further stress.

| rowspan="3" | 23 February

| Liz Ewing

| A prepper who gets daughter Holly (Jasmine Ewing) injured numerous times due to their active lifestyle.

| Jasmine Ewing

| The daughter of Esther (Liz Ewing) who expresses her annoyance with their prepper lifestyle due to wanting a social life.

| Vicki Hackett

| A social worker who investigates Holly McDaid's (Jasmine Ewing) injuries.

| rowspan="2" | 24 February

| Fiona Gillies

| Jimmi Clay's (Morgan) therapist who helps him to realise that he is not at fault for Tim Watkins' (Macklin) suicide.

| Maria Critell

| A patient with stomach pains. Hazeem Durrani (Ejjbair) helps her to realise that her pains may be caused by swallowing one of her tongue piercings.

| rowspan="2" | 28 February

| {{nowrap|Stefan Davis{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHY is Luca McIntyre annoyed with Emma? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-luca-mcintyre-annoyed-with-emma |access-date=1 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=3 March 2022 |archive-url=https://web.archive.org/web/20220303202353/https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-luca-mcintyre-annoyed-with-emma |url-status=live }}}}

| An ex-convict who sells cleaning products on doorsteps. After he saves Clive Waters' (Martin Reeve) from dying, he is wrongfully accused of attacking her. His innocence is proved by her doctors.

| Martin Reeve

| An elderly man who wrongfully accuses Tyrone Biggs (Stefan David) of attacking his wife.

| {{nowrap|1–15 March}}

| {{nowrap|Tina Gray{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Will Jimmi Clay help patient Asif? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-jimmi-clay-help-patient-asif |access-date=1 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=3 March 2022 |archive-url=https://web.archive.org/web/20220303202355/https://www.whattowatch.com/spoilers/doctors-spoilers-will-jimmi-clay-help-patient-asif |url-status=live }}}}

| A dying patient of Luca McIntyre's (McLaren) who expresses her wishes to travel the world. Since she cannot leave her bedroom due to being on end of life care, she offers Luca her travelling ticket before dying.

| rowspan="2" | 1 March

| Jo Woodcock

| A pregnant patient of Ruhma Carter's (Patel) who discovers that the father of her baby, Aaron Miller is her half-brother. She tells him but is disgusted to found out that he knew of their relation and pursued their relationship regardless.

| James Wallwork

| The half-brother of Melissa Benson (Jo Woodcock) who admits that despite knowing of their relation to each other, pursuing their romantic relationship regardless. She kicks him out but says that he can still be part of their baby's life.

| rowspan="3" | 2 March

| Jola Jassy

| The girlfriend of Jay Prime (Jones) who forces her into committing crimes with him.

| Lucas Jones

| An ex-convict who controls Marnie Mobbs (Jassy) by making her commit crimes with him.

| Alice Proctor

| A leaflet deliverer who has her trolley of leaflets stolen by Jay Prime (Lucas Jones) and Cat Moszinski (Alice Proctor).

| rowspan="3" | 3 March

| Patrick Drury{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Zara Carmichael is under pressure! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-zara-carmichael-is-under-pressure |access-date=3 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=23 February 2022 |archive-url=https://web.archive.org/web/20220223175410/https://www.whattowatch.com/spoilers/doctors-spoilers-zara-carmichael-is-under-pressure |url-status=live }}

| An ex-librarian who is caught stealing books he is using to build his own library, following the news of Letherbridge Library closing.

| Victoria Broom

| The daughter of Ted Fletcher (Patrick Drury) who discovers his stealing habits.

| Gethin Alderman

| The head librarian of Letherbridge Library who discovers Ted Fletcher's (Drury) stealing.

| rowspan="3" | 7 March

| Jamie Muscato

| The bandmate of Amy Beaden (Evie Rose Lane) who confesses his romantic feelings for her, only to learn that she is asexual and does not want to pursue a relationship.

| Evie Rose Lane

| A musician who comes out as asexual and is later diagnosed with Asperger syndrome.

| Sophie Dix

| Amy's (Lane) mother who worries about her Asperger's diagnosis.

| rowspan="3" | 8 March

| Norma Atallah

| A difficult and lonely patient at Sutton Vale who Al Haskey (Midlane) puts into contact with a help group for loneliness.

| Jon Ramm

| A computer technician who inapproptiately flirts with receptionist Rosie Colton (Janice Connolly), until Al Haskey (Midlane) warms him off.

| Claire Lichie

| A patient at Sutton Vale who Al Haskey (Midlane) puts onto the correct medication.

| rowspan="3" | 9 March

| Kriss Dosanjh{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHO does Valerie Pitman spring a SURPRISE on? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-valerie-pitman-spring-a-surprise-on |access-date=12 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=1 March 2022 |archive-url=https://web.archive.org/web/20220301175635/https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-valerie-pitman-spring-a-surprise-on |url-status=live }}

| A plasterer who is due to have a minor surgery performed by Sid Vere (Rice), but is forced to work by his ruthless boss, Leo Brinkley (Chris Finch). He collapses at work and threatens Leo with a legal case into unfair working conditions.

| {{nowrap|Kiren Kebaili-Dwyer}}

| Leo Brinkley's (Finch) nephew who is training to be a lawyer whilst also plastering for him. He quits his job after learning that his uncle is a tyrant to his employees, as well as advising colleague Manny Attwall (Kriss Dosanjh) on how to sue Leo.

| Chris Finch

| The boss of Manny Attwall (Dosanjh) who forces him to work despite needing a minor surgery.

| 10 March

| Nicola Wright{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Birthday SURPRISE for Emma Reid! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-birthday-surprise-for-emma-reid |access-date=12 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=3 March 2022 |archive-url=https://web.archive.org/web/20220303202544/https://www.whattowatch.com/spoilers/doctors-spoilers-birthday-surprise-for-emma-reid |url-status=live }}

| A district nurse who verifies the death of Winnie Jones (Tina Gray).

| {{nowrap|10–17 March}}

| Will Barton

| Winnie's (Gray) son who is not distressed when he learns of her death from Luca McIntyre (McLaren). Stuart explains that he felt unappreciated by his mother growing up which led to him moving away. After he learns that Winnie offered Luca a travel ticket before her death, Stuart accuses him of manipulating Winnie, until Luca explains that he does not want to accept the ticket due to his code of practice.

| rowspan="2" | 15 March

| Joshua Ellershaw

| A student at Letherbridge University who is dumped by girlfriend Ruth Day (Isabelle Farah).

| Isabelle Farah

| A student at Letherbridge University who dumps boyfriend Ed Bird (Joshua Ellershaw) after suspecting that he could be gay.

| {{nowrap|16–22 March 2022,}}
{{nowrap|3 October 2023}}

| Maya Barcot

| A physiotherapist who treats Emma Reid (Miles) following a hip injury. Due to having a disagreement with Emma in the past over the care of a patient, Magda is strict and rude whilst treating her. Emma later arranges for Magda to treat Al Haskey (Midlane) after he is attacked, which he reacts badly to.

| 16 March

| Gabrielle Oke

| A nurse who helps Emma Reid (Miles) after she spills spaghetti over herself in hospital.

| rowspan="3" | 17 March

| Niamh Longford{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHY is Bear Sylvester sneaking about? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-bear-sylvester-sneaking-about |access-date=17 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=17 March 2022 |archive-url=https://web.archive.org/web/20220317145255/https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-bear-sylvester-sneaking-about |url-status=live }}

| A 15-year-old schoolgirl who learns that she is pregnant. She affirms that the test must be wrong since she believes she is a virgin, but with Ruhma's help, she uncovers memories of being raped at a party.

| Karen Asemper

| A doctor who helps Sally Hardy (Niamh Longford) with getting an abortion.

| Gabriel Quigley

| The mother of Sally (Longford) who is shocked to learn that her daughter has been raped.

| rowspan="2" | 21 March

| Beth Cordingly{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Will Emma Reid accept some help? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-emma-reid-accept-some-help |access-date=26 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=26 March 2022 |archive-url=https://web.archive.org/web/20220326222303/https://www.whattowatch.com/spoilers/doctors-spoilers-will-emma-reid-accept-some-help |url-status=live }}

| A woman who confides in Al Haskey (Midlane) after she has her children taken away by their father who abuses her.

| {{nowrap|Louise Templeton}}

| Heidi Sitwell's (Beth Cordingly) mother who is unaware that Heidi has been abused.

| rowspan="4" | 22 March

| Catherine Kinsella{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Is Luca McIntyre going to LEAVE Letherbridge? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-is-luca-mcintyre-going-to-leave-letherbridge |access-date=26 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=27 March 2022 |archive-url=https://web.archive.org/web/20220327020746/https://www.whattowatch.com/spoilers/doctors-spoilers-is-luca-mcintyre-going-to-leave-letherbridge |url-status=live }}

| A woman struggling with poverty who witnesses a drug bust. She takes the bag of drugs while nobody is looking and sells them herself, which leads to her arrest after a student overdoses on them.

| Karl Cam

| Carly's (Catherine Kinsella) injured husband who is bedbound and cannot provide for them.

| Mitchell Howie

| A drug dealer who has his drugs stolen by Carly Howell (Kinsella).

| Chloe Cooper

| A student who buys drugs from Carly Howell (Kinsella).

| rowspan="3" | 23 March

| Jacqueline Roberts{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Al Haskey gets BAD NEWS about his mum... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-gets-bad-news-about-his-mum |access-date=26 March 2022 |work=What to Watch |publisher=(Future plc)}}

| A teacher who has a breakdown and walks out due to work pressure. After consulting with Jimmi Clay (Morgan), she meets with the headteacher to discuss the heavy workload.

| Clara Indrani

| The headteacher of Carmen Sterling's (Jacqueline Roberts) school who acts on her concerns of heavy workloads.

| Alex Draper

| A troublesome student who Carmen Sterling (Roberts) supports despite his near-exclusion.

| rowspan="3" | 24 March

| Matt Lanigan{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Will Daniel and Zara replace Al? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-daniel-and-zara-replace-al |access-date=26 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=26 March 2022 |archive-url=https://web.archive.org/web/20220326222306/https://www.whattowatch.com/spoilers/doctors-spoilers-will-daniel-and-zara-replace-al |url-status=live }}

| Megan's (Emma Hollywood) father, carer and teacher who is overprotective of her routine. When he falls ill, he refuses to leave her.

| Emma Hollywood

| A teenager with a terminal illness who becomes too ill to play video games with her friend, Tom Rowlands (Josh Heberden).

| Josh Heberden

| Megan Sanders' (Hollywood) friend who surprises her by showing up to her house to play video games with her.

| rowspan="3" | 28 March

| Amy Cameron{{cite news|url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-valerie-pitman-be-pushed-too-far|title=Doctors spoilers: Will Valerie Pitman be pushed too far?|work=What to Watch|access-date=31 March 2022|last=Timblick|first=Simon|publisher=(Future plc)|archive-date=31 March 2022|archive-url=https://web.archive.org/web/20220331164921/https://www.whattowatch.com/spoilers/doctors-spoilers-will-valerie-pitman-be-pushed-too-far|url-status=live}}

| A woman with chronic pains who uses an online forum for fellow sufferers. She suspects forum user Emily Brookes (Hannah Brownlie) of lying about her illness.

| Hannah Brownlie

| A girl with chronic pain who is accused of lying about her condition. She eventually reveals that due to the death of her mother when she was young, she has been forcing herself to be ill.

| Lesley Dessalles

| A virtual assistant that Valerie Pitman (Sarah Moyle) buys for Emma Reid (Miles).

| rowspan="2" | 29 March

| Hannah Chinn{{cite news|url=https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-goes-on-a-date-with-princess|title=Doctors spoilers: Bear Sylvester goes on a date with Princess!|work=What to Watch|access-date=31 March 2022|last=Timblick|first=Simon|publisher=(Future plc)}}

| A woman whose fiancé died in a terrorist attack. Conspiracy theorist Jonathan Barnbrook (Hal Geller) accuses her of being a crisis actor, leading her to have a breakdown.

| Hal Geller

| A conspiracy theorist who accuses bombing survivor Mari Shaw (Hannah Chinn) of being a crisis actor.

| {{nowrap|30 March–3 October}}

| Diana Payan

| The mother of Maeve (Clelia Murphy) who suffered a stroke. When Gillian receives visits from carers in her home, she is rude to them and sends them away. Maeve puts her in a care home. When Maeve is about to be arrested for fraud, she visits Gillian to inform her that she will be going away for a while.

| rowspan="3" | 30 March

| Hannah Boyde

| A philanthropist who takes in Afghan refugee Damsa Bijan (Sara Faraj) after she sneaks into Serena's van.

| James Benson

| Serena Mason's (Hannah Boyde) neighbour who reports her to the police for having a refugee living with her.

| Sara Faraj

| An Afghan refugee who sneaks into Serena Mason's (Boyde) van due to living in war.

| rowspan="3" | 31 March

| Nicholas Prasad{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Princess Buchanan make a FATAL mistake? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-princess-buchanan-make-a-fatal-mistake |access-date=31 March 2022 |work=What to Watch |publisher=(Future plc) |archive-date=31 March 2022 |archive-url=https://web.archive.org/web/20220331164810/https://www.whattowatch.com/spoilers/doctors-spoilers-will-princess-buchanan-make-a-fatal-mistake |url-status=live }}

| A consultant surgeon who is schmoozed by trainee doctor Princess Buchanan (Laura White). Since he likes her attitude towards her career, he offers a Princess a role in a Mind Hope project that he is running.

| Paul Moriarty

| A man with dementia who visits the Mill with a urinary tract infection. Princess Buchanan (White) accidentally prescribes him antibiotics that he is allergic to.

| Angela Terrence

| George's (Paul Moriarty) daughter who is struggling to care for her father due to being a full-time student.

| rowspan="2" | 4 April

| Kate Wood

| A patient of Sid Vere's (Rice) who is set to have a mole removed in the minor surgery unit (MSU). However, since it has grown in size, he refers her to a dermatologist due to the chance that it could be cancerous.

| Stephen Ventura

| Maddy's (Kate Wood) husband who learns to support his wife over his toy shop.

| {{nowrap|5 April–13 December}}

| Linda Hargreaves{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Princess Buchanan visits her MOODY mum |url=https://www.whattowatch.com/spoilers/doctors-spoilers-princess-buchanan-visits-her-moody-mum |access-date=5 April 2022 |work=What to Watch |publisher=(Future plc) |archive-date=28 March 2022 |archive-url=https://web.archive.org/web/20220328230932/https://www.whattowatch.com/spoilers/doctors-spoilers-princess-buchanan-visits-her-moody-mum |url-status=live }}

| Princess' (White) mother. When Princess meets her for lunch, Constance interrupts their conversation numerous times in favour of work decisions. Princess asks her if she would be able to complete her medical training with her uncle Zach, but Constance refuses to give her any support, claiming that herself and Princess' father have gotten Princess out of enough bad situations. When she learns from Karen Hollins (Pearson) that Princess will be leaving the Mill, she demands to hear why. Princess explains that she has been villainised and bullied there, which led to her training being stopped. Constance lashes out and expresses her disappointment with Princess, who retaliates by saying that she only became a doctor to satisfy Constance out of fear and that she is unhappy.

| rowspan="3" | 5 April

| Rose Reade

| A patient of Ruhma Carter's (Patel) who gets pregnant using Nick Carver's (Sebastian Blunt) sperm. She is set to raise the child with girlfriend Helen Peake (Eloise Joseph), who she learns is also pregnant.

| Eloise Joseph

| The girlfriend of pregnant Charlotte Burrows (Rose Reade) who learns that she is also pregnant.

| Sebastian Blunt

| Charlotte Burrows' (Reade) and Helen Peake's (Joseph) sperm donor who expresses an interest in being involved in their children's lives.

| rowspan="3" | 6 April

| James Robinson

| A grieving man with a young daughter. He begins a relationship with Sarah Martin (Anna Swan) shortly after the death of his wife, but discovers that she has been poisoning his daughter.

| Anna Swan

| The girlfriend of Glenn Winter (James Robinson) who poisons his baby due to wanting the attention that she receives.

| Cathy Murphy

| A detective sergeant who discovers that Sarah Martin (Swan) has been poisoning Glenn Winter's (Robinson) daughter with salt.

| rowspan="2" | 7 April

| Toni Midlane{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO will the new receptionist be? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-will-the-new-receptionist-be |access-date=7 April 2022 |work=What to Watch |publisher=(Future plc) |archive-date=31 March 2022 |archive-url=https://web.archive.org/web/20220331112038/https://www.whattowatch.com/spoilers/doctors-spoilers-who-will-the-new-receptionist-be |url-status=live }}

| An applicant for the receptionist job at Sutton Vale. She meets Scarlett Kiernan (Kia Pegg) at the interview, whom she worked with at a clothing store. Jayne is happy for Scarlett when she receives the job over her.

| Eddie Elliott

| A mole at the interviews for the receptionist position at Sutton Vale. He informs Bear Sylvester (Lee), Zara Carmichael (Walsh) and Daniel Granger (Chambers) of the strengths and weaknesses of the candidates.

| {{nowrap|11–12 April}}

| Jack Davies{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO makes a complaint against Princess Buchanan? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-makes-a-complaint-against-princess-buchanan |access-date=14 April 2022 |work=What to Watch |publisher=(Future plc) |archive-date=18 April 2022 |archive-url=https://web.archive.org/web/20220418094011/https://www.whattowatch.com/spoilers/doctors-spoilers-who-makes-a-complaint-against-princess-buchanan |url-status=live }}

| A teenager who is diagnosed with genital herpes after having a hook-up with a fellow student. Maeve Ludlow (Murphy) learns that he regularly visits the Radar Club in Letherbridge, which she connects to a cough that Dale has.

| rowspan="3" | 11 April

| Emma Williams

| The long-term girlfriend of Patrick Davenport (Ben Keenan) who learns that he has been cheating on her after she contracts syphilis.

| Ben Keenan

| The long-term boyfriend of Freya Marsh (Emma Williams) who has been cheating on her with numerous women in his workplace.

| Dawn Chandler

| A patient who feels offended by Princess Buchanan (White) making comments about her weight whilst she attends a check up.

| rowspan="3" | 12 April

| {{nowrap|Freddie Annobil-Dodoo{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: NEW receptionist Scarlett Kiernan arrives |url=https://www.whattowatch.com/spoilers/doctors-spoilers-new-receptionist-scarlett-kiernan-arrives |access-date=7 April 2022 |work=What to Watch |publisher=(Future plc) |archive-date=18 April 2022 |archive-url=https://web.archive.org/web/20220418094011/https://www.whattowatch.com/spoilers/doctors-spoilers-new-receptionist-scarlett-kiernan-arrives |url-status=live }}}}

| A football coach who suffers from a trauma to his head following his divorce to Tricia Yates (Emma Wilkes). He begins to feel a sexual attraction towards men, which leaves him confused.

| Chris Brazier

| A player on Anthony Sargent's (Freddie Annobil-Dodoo) football team. When Anthony confides in him about his potential homosexuality, Tel assures him that it is fine since he is bisexual himself.

| Emma Wilkes

| The ex-wife of Anthony Sargent (Annobil-Dodoo).

| rowspan="2" | 13 April

| {{nowrap|Sarah Beck Mather{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Bear Sylvester needs advice from Sid |url=https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-needs-advice-from-sid |access-date=7 April 2022 |work=What to Watch |publisher=(Future plc) |archive-date=18 April 2022 |archive-url=https://web.archive.org/web/20220418094010/https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-needs-advice-from-sid |url-status=live }}}}

| A pregnant patient of Ruhma Carter's (Patel) who confides in her about her controlling partner and boss, Mike Whitmore (Glen Fox), who listens to her all day using microphones and cameras. Ruhma helps her to escape.

| Glen Fox

| The controlling partner and boss of Julia Gold (Sarah Beck Mather) who monitors her behaviour all day using microphones and cameras.

| {{nowrap|14 April 2022–2 February 2023}}

| Simon Lowe{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Rob Hollins confronts an armed ROBBER... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-confronts-an-armed-robber |access-date=7 April 2022 |work=What to Watch |publisher=(Future plc) |archive-date=7 April 2022 |archive-url=https://web.archive.org/web/20220407191533/https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-confronts-an-armed-robber |url-status=live }}

| The father of Scarlett (Pegg). He believes he is set to receive a promotion at work that would have a significant wage increase, but he is instead made redundant. He then struggles to get work, leaving Scarlett to provide for the pair of them. When he eventually gets a job, he falls from a ladder and injures his back, meaning he cannot work. After months of Scarlett tiring herself working several jobs, Brian decides to leave to live with his sister, so that Scarlett can live alone and enjoy her youth.

| rowspan="3" | 14 April

| George Parker

| The brother of Lorna (Rose Riley) who is framed for attacking her by Lorna's boyfriend, Travis Heswall (Nick Hardie), who dislikes Jordan.

| Rose Riley

| The sister of Jordan (George Parker) who is attacked by her boyfriend, Travis Heswall (Hardie). Travis frames her brother for the attack, but Rob Hollins (Walker) uncovers the truth.

| Nick Hardie

| Lorna Belo's (Riley) boyfriend who runs an online video platform. He films an attack on Lorna, framing her brother for it, but is eventually found out and arrested.

| rowspan="2" | 2 May

| Oliver Anthony

| A man who holds Emma Reid (Miles) hostage after suffering psychosis after taking drugs dealt to him by local drug dealer, Gary McMullen (Mark Holgate).

| Angela Bain

| A temporary receptionist at Sutton Vale who is a fan of Dolly Parton.

| {{nowrap|3–9 May}}

| Mark Holgate

| A drug dealer who deals to teenagers at a nightclub. Maeve Ludlow (Murphy) notices a pattern of behaviour that users of the drug exhibit and tracks Gary down, pleading him to stop.

| rowspan="2" | 3 May

| Eri Shuka

| An agency cleaner who is hired by Al Haskey (Midlane). Whilst at his house, she is confronted by Ross Dempster (René Zagger), whose ring she stole. Since the pair are interested in each other romantically, he forgives her and offers her a new job.

| René Zagger

| A stockbroker who confronts Elsa Golden (Eri Shuka) after he notices that she has stolen a ring from his home. He does not report Elsa since he enjoys her company romantically and offers her a new job as his executive assistant.

| rowspan="2" | 4 May

| Heather Craney{{cite news|url=https://www.whattowatch.com/spoilers/doctors-spoilers-karen-hollins-meets-a-tarot-card-reader|title=Doctors spoilers: Karen Hollins meets a tarot card reader|work=What to Watch|access-date=6 May 2022|last=Timblick|first=Simon|publisher=(Future plc)|archive-date=26 April 2022|archive-url=https://web.archive.org/web/20220426073416/https://www.whattowatch.com/spoilers/doctors-spoilers-karen-hollins-meets-a-tarot-card-reader|url-status=live}}

| A woman who experiences psychosis after she stops taking her medication and instead relies on tarot cards. As part of her delusions, she sees her abusive ex-partner, Vincent Blake (Matthew Flynn), who killed himself after their relationship ended.

| Matthew Flynn

| The dead abusive ex-partner of Heather Corcoran (Heather Craney) who appears in her psychosis delusions.

| rowspan="3" | 5 May

| Faye Campbell{{cite news|url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-princess-buchanan-cause-trouble-for|title=Doctors spoilers: WHO does Princess Buchanan cause trouble for?|work=What to Watch|access-date=6 May 2022|last=Timblick|first=Simon|publisher=(Future plc)|archive-date=6 May 2022|archive-url=https://web.archive.org/web/20220506141224/https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-princess-buchanan-cause-trouble-for|url-status=live}}

| A student midwife who shadows Ruhma Carter (Patel). Her first birth is revealed to be Kerry Wilson (Tiana Mai Jackson), who bullied her throughout school. She attempts to get Megan fired for stealing, but her plan fails.

| {{nowrap|Tiana Mai Jackson}}

| A pregnant patient at St. Phils Hospital who learns that former classmate Megan Chalmers (Faye Campbell) is one of her midwives. Kerry bullied Megan in school and continues her vendetta against her by attempting to get her fired from her midwifery duties.

| Susan Ateh

| A patient of Ruhma Carter's (Patel) and Megan Chalmers' (Campbell).

| rowspan="2" | 9 May

| Satnam Bhogal

| The director of primary care for the clinical commissioning group who unexpectedly arrives at Sutton Vale for a surprise inspection.

| Susie Fairfax

| A demanding patient who insists on seeing Jimmi Clay (Morgan) despite missing her appointment. Scarlett Kiernan (Pegg) affirms to her that she will have to wait for Jimmi to be free, but Denise ignores her, and wanders around the surgery to find Jimmi.

| rowspan="2" | 10 May

| Lewis Adler{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO is keeping an eye on Princess Buchanan? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-is-keeping-an-eye-on-princess-buchanan |access-date=12 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=12 May 2022 |archive-url=https://web.archive.org/web/20220512150409/https://www.whattowatch.com/spoilers/doctors-spoilers-who-is-keeping-an-eye-on-princess-buchanan |url-status=live }}

| An elderly man who is unable to care for himself properly due to tremors he experiences following a stroke. He befriends Cherif Moore (Byron Easmon), who he invites into his home as a live-in caregiver.

| Byron Easmon

| A homeless teenager at Letherbridge University who is facing money issues. He is invited to live with Michael Arnessen (Lewis Adler) if he agrees to care for him.

| rowspan="3" | 11 May

| Mary Roscoe{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO flirts with Emma Reid? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-flirts-with-emma-reid |access-date=12 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=6 May 2022 |archive-url=https://web.archive.org/web/20220506142348/https://www.whattowatch.com/spoilers/doctors-spoilers-who-flirts-with-emma-reid |url-status=live }}

| A woman whose daughter went missing two years ago. Whilst a search for Clare Howard's (Samantha Seager) missing daughter is underway, they find Alannah's daughter's dead body.

| {{nowrap|Samantha Seager}}

| A woman who believes her daughter has gone missing. However, after a day of searching, she shows up home drunk after a night of drinking.

| Lucky Sanghera

| Clare Howard's (Seager) support officer.

| rowspan="4" | 12 May

| Holly Maguire{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Can Sid Vere help a homeless teenager? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-sid-vere-help-a-homeless-teenager |access-date=12 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=6 May 2022 |archive-url=https://web.archive.org/web/20220506142634/https://www.whattowatch.com/spoilers/doctors-spoilers-can-sid-vere-help-a-homeless-teenager |url-status=live }}

| A teenager with anorexia who runs away from home after her father, Ben Jackson (Grant Burgin), tries to make her get help for her anorexia.

| Grant Burgin

| Mia (Holly Maguire) and Grace's (Madeleine Edmondson) father who deals with Mia going missing and Grace being groomed and almost sold into a human trafficking ring.

| Madeleine Edmondson

| The sister of Mia (Maguire) who has gone missing. Chips (Nick Harris) contacts Grace, tricking her into coming to his house where he claims he has found Grace. He locks Grace away and arranges for a human trafficking ring to pay to have sex with her, but they are interrupted by the police before a deal can be made.

| Nick Harris

| A pimp who tries to sell an underage Mia Jackson (Edmondson) to a human trafficking ring.

| rowspan="3" | 16 May

| Meg Hateley{{cite news|url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-princess-buchanan-target|title=Doctors spoilers: WHO does Princess Buchanan target?|work=What to Watch|access-date=18 May 2022|publisher=(Future plc)|last=Timblick|first=Simon|archive-date=12 May 2022|archive-url=https://web.archive.org/web/20220512150342/https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-princess-buchanan-target|url-status=live}}

| A 22-year-old woman who has a consultation with Al Haskey (Midlane) to discuss her health problems. She rushes to the toilet and unexpectedly gives birth due to experiencing a cryptic pregnancy.

| Rebecca Clay

| Amelia's (Meg Hateley) mother who is shocked but excited to learn that she has unexpectedly given birth.

| Eddie Eyre

| Amelia Crosby's (Hateley) ex-boyfriend who is initially unsupportive of their unexpected child, but later agrees to be there for the pair of them.

| rowspan="2" | 17 May

| Rachel Caffrey{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Is ROMANCE in store for Maeve Ludlow? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-is-romance-in-store-for-maeve-ludlow |access-date=17 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=19 May 2022 |archive-url=https://web.archive.org/web/20220519225158/https://www.whattowatch.com/spoilers/doctors-spoilers-is-romance-in-store-for-maeve-ludlow |url-status=live }}

| A patient of Zara Carmichael's (Walsh) who has a consultation with her to prevent the sickness she feels from being pregnant so that she can work. She confides in boss Reza Hosseini (Dann Kharsa), who supports Hayley with her pregnancy.

| Dann Kharsa

| The boss of Hayley Baxter (Rachel Caffrey) who is angry when she slacks at work but becomes supportive when he learns that she is pregnant.

| 17–18 May

| Paddy Stafford

| A burglar who visits Valerie Pitman's (Moyle) house. After defecating in her kitchen and taking all of her electronic devices, he finds Valerie, attacks her, ties her up and demands she give him the PIN codes for all of her bank cards. He escaped with her belongings and later phones Valerie to threaten that he will come back using her house keys.

| 18 May

| Nikki Patel{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Doctors spoilers: Valerie Pitman gets a late night FRIGHT! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-gets-a-late-night-fright |access-date=18 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=19 May 2022 |archive-url=https://web.archive.org/web/20220519225158/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-gets-a-late-night-fright |url-status=live }}

| A police officer who is tired of being overworked, underpaid and unappreciated. As she is quitting her job, she is called out to Valerie Pitman (Moyle), who has been burgled by Kris Marsh (Paddy Stafford). Valerie's appreciation for Shelley's time convinces her not to quit.

| rowspan="2" | 19 May

| Abii Strudwicke{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Doctors spoilers: Who BLACKMAILS Scarlett Kiernan? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-blackmails-scarlett-kiernan |access-date=19 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=19 May 2022 |archive-url=https://web.archive.org/web/20220519225201/https://www.whattowatch.com/spoilers/doctors-spoilers-who-blackmails-scarlett-kiernan |url-status=live }}

| A former colleague of Scarlett Kiernan's (Pegg) who is surprised to learn that she is working at Sutton Vale. She blackmails Scarlett, demanding that she reads Matt Hawthorn's (James Mateo-Salt) patient records, and if she does not comply, she will tell Sid Vere (Rice) that Scarlett has broken patient confidentiality guidelines. Scarlett refuses and Sid does not believe Gemma's lies, so she affirms that she will make Scarlett a social outcast.

| {{nowrap|James Mateo-Salt}}

| The boyfriend of Gemma Porter (Abii Strudwicke), who is unaware that Gemma has been cheating on him and could have given him an STI.

| rowspan="3" | 23 May

| Danny Horn{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Valerie Pitman is haunted by the burglary... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-is-haunted-by-the-burglary |access-date=23 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=25 June 2022 |archive-url=https://web.archive.org/web/20220625111832/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-is-haunted-by-the-burglary |url-status=live }}

| A man who serially proposes to women in attempts to secure a meaningful relationship. He realises his issue after Vicky Cotton (Amy McCallum) refuses to marry him.

| Jon Chew

| A waiter who witnesses Eddie McDonald (Danny Horn) proposing to Vicky Cotton (McCallum) and offers to call a taxi for her when she rushes out.

| Amy McCallum

| A woman who denies Eddie McDonald's (Horn) proposal to her due to not feeling a romantic connection to him.

| rowspan="3" | 24 May

| Tom Lorcan{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: There's a paintball SHOOTOUT on today's episode! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-theres-a-paintball-shootout-on-todays-episode |access-date=24 May 2022 |work=What to Watch |publisher=(Future plc)}}

| Lauren's (Natasha Alderslade) husband who discovers that she had an affair with his friend, Miles Dryden (Benjamin Wilkin), during the couple's rough patch.

| Natasha Alderslade

| Josh's (Tom Lorcan) wife who reveals that she had an affair with his friend, Miles Dryden (Wilkin), whilst the pair had a rough patch in their marriage.

| Benjamin Wilkin

| Josh Tiverton's (Lorcan) friend who is ditched after Josh learns that he had an affair with his wife, Lauren (Alderslade).

| rowspan="3" | 25 May

| Catherine Hamilton{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Can Scarlett Kiernan keep her job? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-scarlett-kiernan-keep-her-job |access-date=25 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=7 June 2022 |archive-url=https://web.archive.org/web/20220607113539/https://www.whattowatch.com/spoilers/doctors-spoilers-can-scarlett-kiernan-keep-her-job |url-status=live }}

| A woman suffering from health anxiety who has a history of self-diagnosing herself and family members. As she finally accepts help from Sid Vere (Rice), she is thrown out by husband Shane (Mark Rose).

| Mark Rose

| The husband of Annette (Catherine Hamilton) who tires of her health anxiety and throws her out of their house.

| Jess Kambitsis

| The daughter of Annette (Hamilton) and Shane (Rose).

| rowspan="2" | 26 May

| Samantha Power{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Jimmi Clay goes on a date with Maeve! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-jimmi-clay-goes-on-a-date-with-maeve |access-date=26 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=26 May 2022 |archive-url=https://web.archive.org/web/20220526215618/https://www.whattowatch.com/spoilers/doctors-spoilers-jimmi-clay-goes-on-a-date-with-maeve |url-status=live }}

| Zara Carmichael (Walsh) and Daniel Granger's (Chambers) cleaner who collapses in their bathroom.

| Rachel Barnwell

| Ronnie's (Samantha Power) daughter who is shocked to learn that she is working two jobs to pay for Tamzin and her daughter's lifestyle.

| {{nowrap|30 May–14 June}}

| Kath Thickett{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Princess Buchanan is BACK! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-princess-buchanan-is-back |access-date=4 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=26 May 2022 |archive-url=https://web.archive.org/web/20220526103823/https://www.whattowatch.com/spoilers/doctors-spoilers-princess-buchanan-is-back |url-status=live }}

| The PR agent for Letherbridge's committee for the 2022 Commonwealth Games. She works with Valerie Pitman (Moyle), who becomes the mascot for the games.

| rowspan="2" | 30 May

| {{nowrap|Mark Rice-Oxley}}

| An artist dying from a brain tumour. He tells Patsy Walthe (Emma Beattie), his partner, that he is dying and wants to spend his final moments happy with her.

| Emma Beattie

| The partner of Diarmud Conroy (Mark Rice-Oxley) who struggles to accept that he is dying. Once she comes to terms with his diagnosis, she vows to be with him until he dies.

| rowspan="3" | 31 May

| Jennifer Barron{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Valerie Pitman becomes Leona the Lion! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-becomes-leona-the-lion |access-date=4 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=25 June 2022 |archive-url=https://web.archive.org/web/20220625111740/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-becomes-leona-the-lion |url-status=live }}

| A diabetic patient of Al Haskey's (Midlane). She naps in one of the unused rooms at the Mill and Al asks receptionist Scarlett Kiernan (Pegg) to check on her. Chloe's condition deteriorates and she is eventually taken away in an ambulance.

| Geoffrey Maccarthy

| A patient of Princess Buchanan's (White) who confides in her about being the victim of a shock attack. She assures him that he is not to blame for the attack.

| Matt Sutton

| A man who witnessed Nathan Jones (Geoffrey Maccarthy) being attacked.

| rowspan="2" | 1 June

| Nadine Higgin{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO refuses to help Princess Buchanan? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-refuses-to-help-princess-buchanan |access-date=26 May 2022 |work=What to Watch |publisher=(Future plc) |archive-date=26 May 2022 |archive-url=https://web.archive.org/web/20220526103728/https://www.whattowatch.com/spoilers/doctors-spoilers-who-refuses-to-help-princess-buchanan |url-status=live }}

| The pregnant wife of boxer Naija (Foluke Anglin) who begins to worry about Naija's avoidance of her. After seeing her attending a doctor's appointment at Sutton Vale, she questions Naija, who reveals that she may have dementia.

| Foluke Anglin

| A boxer and the wife of Aminah (Nadine Higgin), who is pregnant with their child. She reveals to Aminah that she may have dementia caused by a head injury and that she plans on doing one last fight to earn money for their forthcoming child.

| 6–14 June

| {{nowrap|India Lily Cooper{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: DISASTER for Leona the Lion! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-disaster-for-leona-the-lion |access-date=6 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=31 May 2022 |archive-url=https://web.archive.org/web/20220531172511/https://www.whattowatch.com/spoilers/doctors-spoilers-disaster-for-leona-the-lion |url-status=live }}}}

| A school student who steals Valerie Pitman's (Moyle) mascot costume for the Commonwealth Games. She later informs Valerie that she originally designed the mascot's costume but her idea was stolen, and in return, Valerie helps her to meet Kadeena Cox.

| rowspan="2" | 6 June

| Barry McCarthy

| A widow who feels lonely without his dead wife. After his appointment with Zara Carmichael (Walsh), he sits in the reception area trying to talk to other patients before being asked to leave.

| Colette Kelly

| A patient of Zara Carmichael's (Walsh) who denies Wilber Eaton's (Barry McCarthy) friendly advances due to believing he is a womaniser.

| rowspan="4" | 7 June

| Ellie Bindman{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: SHOCK for Sid Vere... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-shock-for-sid-vere |access-date=7 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=7 June 2022 |archive-url=https://web.archive.org/web/20220607141144/https://www.whattowatch.com/spoilers/doctors-spoilers-shock-for-sid-vere |url-status=live }}

| The daughter of Michelle (Julia Riley) who has been groomed online. Cathy Jenkins (Laura Bayston) contacts the man who groomed her and proves that he is a paedophile.

| Julia Riley

| The mother of Amy (Ellie Bindman) who helps her see that she has been groomed.

| Kevin Murphy

| The stepfather of Amy (Bindman).

| Derek Griffiths

| A patient of Sid Vere's (Rice) who dies unexpectedly after seeing him for a consultation.

| rowspan="3" | 8 June

| {{nowrap|Shareesa Valentine{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Bear Sylvester confronts Nurse Jenkins... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-confronts-nurse-jenkins |access-date=9 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=9 June 2022 |archive-url=https://web.archive.org/web/20220609153402/https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-confronts-nurse-jenkins |url-status=live }}}}

| An ex-prisoner who was abused by her father as a child. She returns to her family home after her release in an attempt to find her mother who was also abused by him, but finds Edie Parfitt (Anne Kidd) living there. She helps to reunite Mel with her mother, Maggie (Andrea Crewe).

| Anne Kidd

| A woman who lives in Mel Stuart's (Shareesa Valentine) childhood home. When she finds Mel in her house, she calls the police under the assumption that she has broken in, but later learns that Mel was expecting her mother to be living there.

| Andrea Crewe

| Mel's (Valentine) mother who was abused by her husband.

| 9 June

| Zita Sattar{{cite news |last1=Timblick |first1=Simon |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-is-emma-reid-reunited-with |title=Doctors spoilers: WHO is Emma Reid reunited with? |access-date=6 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=9 June 2022 |archive-url=https://web.archive.org/web/20220609153401/https://www.whattowatch.com/spoilers/doctors-spoilers-who-is-emma-reid-reunited-with |url-status=live }}

| The leader of a restorative justice programme at Letherbank HMP. She works with Emma Reid (Miles) and Jasmine Dajani (Lara Sawalha) to speak with their attacker, Blake Atkins (Louis Stannett).

| rowspan="2" | 13 June

| Victoria Wicks{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Scarlett Kiernan is out for PAYBACK on Princess! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-is-out-for-payback-on-princess |access-date=20 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=7 June 2022 |archive-url=https://web.archive.org/web/20220607113539/https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-is-out-for-payback-on-princess |url-status=live }}

| An author who sees Al Haskey (Midlane) about symptoms that he concluded is arsenic poisoning. Since he is worried for her life, he calls Jenny in, but she is pleased as she invented the symptoms to see if the plot of her book is realistic. Al demands that she leaves and lectures her about the waste of NHS time.

| John Bowler

| The husband of Jenny who is shocked to learn that she has faked symptoms for the sake of her book wtiting.

| rowspan="3" | 14 June

| Simon Meacock{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Valerie Pitman is off on a SNEAKY mission! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-is-off-on-a-sneaky-mission |access-date=20 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=25 June 2022 |archive-url=https://web.archive.org/web/20220625111834/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-is-off-on-a-sneaky-mission |url-status=live }}

| A homeless man who is shocked to learn that he has been the victim of a random attack from teenagers.

| Charlie Partridge

| A mascot for a Letherbridge sports team who Valerie Pitman (Moyle) meets.

| Kadeena Cox

| A paralympian who takes photos with Clara Robertson (India Lily Cooper), who is hoping to become an athlete like her.

| {{nowrap|16 June–6 September}}

| Pandora Clifford{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO makes an accusation against Maeve Ludlow? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-makes-an-accusation-against-maeve-ludlow |access-date=20 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 June 2022 |archive-url=https://web.archive.org/web/20220620192647/https://www.whattowatch.com/spoilers/doctors-spoilers-who-makes-an-accusation-against-maeve-ludlow |url-status=live }}

| The wife of Jacob, the former lead GP of Sutton Vale before his sudden disappearance. She arrives at the surgery to claim all of the paintings in the building since they were bought with his money. Steph tells them that since Jacob left their family so suddenly with no way to pay the bills, the paintings will be useful. She also warns them about Maeve Ludlow (Murphy), Rosie Colton (Connolly) and Princess Buchanan (White). DI Mick Hartley (Martin Walsh) suspects that Steph is guilty of killing Jacob and Rob Hollins (Walker) realises that his head injuries were caused by the families' forklift. They question her, and after her initial attempts to lie and then escape, she admits to murdering him and burying his body.

| rowspan="2" | 16 June

| Joey Lockhart

| A man with a pornography addiction who is scared to have sex with girlfriend Cat Roberts (Sarah Jane Fineux) for the first time.

| {{nowrap|Sarah Jane Fineux}}

| The girlfriend of Ki Morgan (Joey Lockhart) who is preparing to have sex with him for the first time.

| {{nowrap|20 June–16 September}}

| Vicky Hall{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Princess Buchanan get SACKED? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-princess-buchanan-get-sacked |access-date=20 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 June 2022 |archive-url=https://web.archive.org/web/20220620192750/https://www.whattowatch.com/spoilers/doctors-spoilers-will-princess-buchanan-get-sacked |url-status=live }}

| An employee of the Midlands Disease Control (MDC) who informs the management of the Mill that they need to shut down the surgery temporarily due to an outbreak of legionnaires' disease. She later finds that they are not responsible for the outbreak.

| rowspan="3" | 20 June

| Bill Blackwood

| A man who has become accustomed to his house being broken into. He catches Rhys Lincombe (A J Greaves) in his living room but does not report him to Rob Hollins (Walker) after he learns of his abusive father.

| A J Greaves

| The diabetic brother of Elias (Isaac Wiles) who tries to steal from Nick Shroffield's (Bill Blackwood) house to provide for them both due to their abusive father not caring for them.

| Isaac Wiles

| The brother of Rhys (Greaves) who searches for him due to him having low blood sugar whilst robbing a house.

| {{nowrap|21 June–6 September}}

| Martin Walsh{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: MURDER in Letherbridge! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-murder-in-letherbridge |access-date=25 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=13 June 2022 |archive-url=https://web.archive.org/web/20220613230705/https://www.whattowatch.com/spoilers/doctors-spoilers-murder-in-letherbridge |url-status=live }}

| The detective inspector in charge of the investigation into Jacob Ashdown's murder. After being told he can have another person on his team, he recruits the help of Rob Hollins (Walker) for the case.

| rowspan="2" | 21 June

| Matt Whitchurch

| The anxious husband of pregnant Michelle (Bairavi Manoharan) who suffers from panic attacks in the lead up to her giving birth.

| {{nowrap|Bairavi Manoharan}}

| The wife of Chris (Matt Whitchurch) who is shocked to learn that he has been having panic attacks.

| {{nowrap|22 June, 6 September}}

| {{nowrap|Christopher Rutter{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Rosie Colton knows WHO killed Jacob! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-rosie-colton-knows-who-killed-jacob |access-date=25 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=25 June 2022 |archive-url=https://web.archive.org/web/20220625111834/https://www.whattowatch.com/spoilers/doctors-spoilers-rosie-colton-knows-who-killed-jacob |url-status=live }}}}

| One of the sons of Jacob and Steph Ashdown (Pandora Clifford).

| rowspan="3" | 23 June

| Barry Aird{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Maeve Ludlow SECRET AFFAIR exposed! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-maeve-ludlow-secret-affair-exposed |access-date=25 June 2022 |work=What to Watch |publisher=(Future plc) |archive-date=14 June 2022 |archive-url=https://web.archive.org/web/20220614132636/https://www.whattowatch.com/spoilers/doctors-spoilers-maeve-ludlow-secret-affair-exposed |url-status=live }}

| The father of Jessie (Charlotte King) who is indoctrinated by a toxic masculinity group led by Ray Lafferty (David Broughton-Davies). Jessie helps him to see that his views are misogynistic and get help.

| Charlotte King

| The daughter of Dave (Barry Aird) who educates him on his misogynistic views.

| {{nowrap|David Broughton-Davies}}

| The leader of a men's group that promotes toxic masculinity and hatred towards women.

| rowspan="3" | 5 September

| Christine Ozanne{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO gives Princess Buchanan an alibi? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-gives-princess-buchanan-an-alibi |access-date=3 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 September 2022 |archive-url=https://web.archive.org/web/20220905125941/https://www.whattowatch.com/spoilers/doctors-spoilers-who-gives-princess-buchanan-an-alibi |url-status=live }}

| A former patient of Dr. Ashdown's who is saddened to hear of his death. She informs Maeve Ludlow (Murphy) of her plans to donate all of her savings as a reward for those with information on his death. Maeve snaps at Doris and tells her that her plan is daft.

| Beth Tuckey

| A friend of Rosie Colton's (Connolly). She visits Rosie in the aftermath of Dr. Ashdown's death and presses Rosie for gossip, who throws Mary out.

| Emma Keele

| The coordinator of a painting class that Eve Haskey (Rachel Bell) persuades Al (Midlane) to take her to.

| rowspan="3" | 6 September

| Corinna Brown{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Steph Ashdown has a SHOCK SECRET! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-steph-ashdown-has-a-shock-secret |access-date=3 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=2 March 2023 |archive-url=https://web.archive.org/web/20230302183444/https://www.whattowatch.com/spoilers/doctors-spoilers-steph-ashdown-has-a-shock-secret |url-status=live }}

| A patient of Sid Vere's (Rice) who is set to have a mole removed. Her sister, Melissa (Leanne Dunstan), interrupts the procedure to reveal that Chelsea is pregnant.

| Leanne Dunstan

| The older sister of Chelsea (Corinna Brown). When she learns that Chelsea is pregnant, she urges her to consider every option, revealing that she had an abortion when she was younger.

| Lesley Dessalles

| A newsreader who Princess Buchanan (White) and Rosie Colton (Connolly) watch break the news that Dr. Ashdown's murderer has been taken into custody.

| rowspan="2" | 7 September

| Joey Phillips{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Can Valerie Pitman solve the MYSTERY of the Mantis Man? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-valerie-pitman-solve-the-mystery-of-the-mantis-man |access-date=3 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=12 September 2022 |archive-url=https://web.archive.org/web/20220912105906/https://www.whattowatch.com/spoilers/doctors-spoilers-can-valerie-pitman-solve-the-mystery-of-the-mantis-man |url-status=live }}

| rowspan="2" | A couple who break up following the death of their young child.

| Marilyn Nnadebe

| rowspan="3" | 8 September

| Colin Tierney{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: EMERGENCY for Al Haskey... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-emergency-for-al-haskey |access-date=3 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=4 September 2022 |archive-url=https://web.archive.org/web/20220904125253/https://www.whattowatch.com/spoilers/doctors-spoilers-emergency-for-al-haskey |url-status=live }}

| A seargent at Letherbridge Police Station on patrol in the park who finds Naomi Ball (Kya Brame), the victim of an acid attack. He arrests Kyle Jessop (George Hannigan) after garnerning a confession, and he attacks Kyle in his cell.

| Kya Brame

| A woman who leaves an abusive relationship with Kyle Jessop (Hannigan). He retaliates by attacking her with acid.

| George Hannigan

| The abusive ex-boyfriend of Naomi Ball (Brame). After she ends their relationship, he attacks her with acid. He confesses to the assault and affirms that he will kill her once released. He is attacked in his cell by Liam Walsh (Colin Tierney).

| 12, 16 September

| Eliza Hunt{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO offers Princess Buchanan another chance? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-offers-princess-buchanan-another-chance |access-date=3 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=4 September 2022 |archive-url=https://web.archive.org/web/20220904125253/https://www.whattowatch.com/spoilers/doctors-spoilers-who-offers-princess-buchanan-another-chance |url-status=live }}

| rowspan="3" | People affected by the Legionnaire's outbreak in Letherbridge. Al Haskey (Midlane) interviews them and tries to connect the common theme between their whereabouts to find the source of the outbreak.

| rowspan="3" | 12 September

| Timothy Speyer

| Victoria May

| Kyle O'Gara

| A patient of Princess Buchanan's (White) who she helps after a car accident.

| rowspan="3" | 13 September

| Gem Carmella{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Sid Vere is reunited with an ex-girlfriend! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-is-reunited-with-an-ex-girlfriend |access-date=17 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 September 2022 |archive-url=https://web.archive.org/web/20220920170639/https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-is-reunited-with-an-ex-girlfriend |url-status=live }}

| An ex-girlfriend of Sid Vere's (Rice) whose new boyfriend has been released from prison.

| Jake Burgum

| The boyfriend of Willa Jeffries (Gem Carmella) who has just been released from prison.

| Luke Goddard

| A prison officer at HMP Letherbank.

| 14 September

| Richard Sutton{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Princess Buchanan get to keep her job at The Mill? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-princess-buchanan-get-to-keep-her-job-at-the-mill |access-date=17 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 September 2022 |archive-url=https://web.archive.org/web/20220920170857/https://www.whattowatch.com/spoilers/doctors-spoilers-will-princess-buchanan-get-to-keep-her-job-at-the-mill |url-status=live }}

| A homeless man who believes he has been attacked by killer robots sent by the CIA.

| rowspan="3" | 15 September

| Ellie James{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO does Scarlett Kiernan have a crush on? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-scarlett-kiernan-have-a-crush-on |access-date=17 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 September 2022 |archive-url=https://web.archive.org/web/20220920170951/https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-scarlett-kiernan-have-a-crush-on |url-status=live }}

| rowspan="2" | Two pregnant wives who are patients of Ruhma Carter (Patel). They are aided by their gay neighbour, Andrew Cowley (Wesley Charles), in becoming pregnant. When he becomes invested in the upbringing of their children, Tanya disapproves despite Lauren's hope for him to be involved.

| Julianna Kurokawa

| Wesley Charles

| The gay neighbour of Lauren (Ellie James) and Tanya Pascoe (Julianna Kurokawa). He aids the couple in artificially inseminating and becomes emotionally invested in the upbringing of their children, to the distaste of Tanya.

| rowspan="4" | 16 September

| Natasha Patel{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Al Haskey faces his greatest FEAR... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-faces-his-greatest-fear |access-date=17 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 September 2022 |archive-url=https://web.archive.org/web/20220920171125/https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-faces-his-greatest-fear |url-status=live }}

| Eve Haskey's (Bell) doctor who cares for her during her time suffering from Leggionnaires' disease.

| Kirsty Averton

| A police constable who has recently been exonerated after a false imprisonment. She takes a statement from stab victim Gary Todd (Harry Long), but after he refuses to be medically examined by Emma Reid (Miles), he dies from sepsis shock.

| Harry Long

| A man who has been stabbed and assaulted after meeting up with someone from a gay hookup app. He does not report it and after eventually giving a statement to PC Anna Fleming (Kirsty Averton), he dies from sepsis shock.

| Avita Jay

| The wife of Gary (Long) who is horrified to come home from a conference and find he has been assaulted. She talks him into reporting it and is later informed that he has died from sepsis shock from a stab wound.

| rowspan="3" | 20 September

| Robbie Curran{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Maeve Ludlow is afraid she'll lose her job... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-maeve-ludlow-is-afraid-shell-lose-her-job |access-date=20 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 September 2022 |archive-url=https://web.archive.org/web/20220920173436/https://www.whattowatch.com/spoilers/doctors-spoilers-maeve-ludlow-is-afraid-shell-lose-her-job |url-status=live }}

| A man with learning difficulties who saves two teenage gang members from drowning in a reservoir. He later reveals that he considered leaving one of them, Harvey, to drown since he had been ableist to Michael.

| David Gillespie

| Michael's (Robbie Curran) father.

| Louise Willoughby

| The mother of Harvey, a teenage boy that Michael Nolan (Curran) saved from drowning. Sid Vere (Rice) exposes her for lying about Harvey's health online in an attempt to scrounge a free holiday.

| rowspan="3" | 21–22 September

| Giuseppe Graham{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHY is Ruhma Carter feeling down in the dumps? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-ruhma-carter-feeling-down-in-the-dumps |access-date=20 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=22 September 2022 |archive-url=https://web.archive.org/web/20220922132800/https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-ruhma-carter-feeling-down-in-the-dumps |url-status=live }}

| Izzie Torres' (Bethan Moore) friend from school who she invites to stay with her at Daniel Granger's (Chambers) house. Daniel is wary of the pair when they shut their bedroom door, but Daniel later concludes that Taylor is gay. Izzie corrects him, informing him that Taylor is genderfluid and queer. Taylor later bonds with Daniel and confesses that they have a crush on Izzie, but do not want to ruin their friendship.

| Charlotte Melia

| A wellness class coach at a spa retreat that Zara Carmichael (Walsh), Ruhma Carter (Patel), Valerie Pitman (Moyle) and Emma Reid (Miles) attend. After Zara excels in her classes, Saffron confides in her that she was formerly in the army and uses wellness as her own form of therapy for what she saw in the wars.

| Trudi Jackson

| A cleaner at the spa retreat where Saffron Meadows (Charlotte Melia) works. She gives good advice to Ruhma Carter (Patel) about her grief over Heston (Owen Brenman), as well as advising Valerie Pitman (Moyle) on listening to others. She flirts with Emma Reid (Miles) and the pair have sex.

| rowspan="5" | 23 September

| Lola Sattar{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Scarlett Kiernan finds an ABANDONED baby! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-finds-an-abandoned-baby |access-date=20 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=23 September 2022 |archive-url=https://web.archive.org/web/20220923111951/https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-finds-an-abandoned-baby |url-status=live }}

| A fifteen-year-old who gives birth to a baby and abandons it at a local church. She regrets her decision and goes back to get her, but finds that Scarlett Kiernan (Pegg) has found the baby. Scarlett notices a fever and takes the baby into the Mill and later sees bruising on the baby's leg. Suspecting it could be sepsis, an ambulance is called and Scarlett informs Shona that social services have gotten involved.

| Sarah Bennington

| A grieving woman who has recently lost her child. She visits the Mill to give all of her baby products to Ruhma Carter (Patel) so that one of her patients can make use of them, but later gives them to Shona Greenhalgh (Lola Sattar).

| Elliott Rogers

| A 21-year-old man who has raped Shona Greenhalgh (Sattah). When he learns of her pregnancy, he demands that she terminates the pregnancy since a baby would be evidence.

| Rosalind Ayres

| A woman with Parkinson's disease who is cared for by husband John (Martin Jarvis). She sees Princess Buchanan (White) and incorrectly refers to her as Sarah. Seeing how upset Ellie gets at being confused, Princess goes along with it. She also helps the state of Ellie's hands by giving her free stress balls.

| Martin Jarvis

| The husband of Ellie (Rosalind Ayres) and her carer. Princess Buchanan (White) notices his poor eyesight and suggests he get an eye test and contact the DVLA. He snaps at Princess and informs her that driving is his lifeline due to his wife's Parkinson's. He later crashes his car in the Mill's car park and snaps at her again, but later thanks Princess for her help.

| rowspan="4" | 26 September

| Mark Ramsay

| A patient of Maeve Ludlow's (Murphy) who has diabetes. Maeve snaps at him for not taking care of himself and he later collapses, calling for Maeve's help.

| Ruth Evans

| A patient at Sutton Vale who is disgusted when she gets help from Maeve Ludlow (Murphy), a nurse prescriber, since she requires a fully qualified doctor to refer her for a scan.

| Esther Ridgway

| A patient of Maeve Ludlow's (Murphy) who thanks Maeve for the care plan she put together for her. She calls an ambulance for Maeve when another of her patients, Mitch Tothill (Mark Ramsay), collapses.

| Darren Hill

| A client of Roxy Piper's (Fiona Skinner). He refuses to pay and is kicked out of her brothel, and when he sees Emma Reid (Miles) at the doorstep, he tries to talk her into having sex with him.

| rowspan="3" | 27 September

| Hiral Varsani{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Bear Sylvester reveal his SHOCK DISCOVERY? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-bear-sylvester-reveal-his-shock-discovery |access-date=20 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=23 September 2022 |archive-url=https://web.archive.org/web/20220923112024/https://www.whattowatch.com/spoilers/doctors-spoilers-will-bear-sylvester-reveal-his-shock-discovery |url-status=live }}

| A new mother who has to go back to work to support her family. She warns husband Max (Rishi Rian) about her toxic family and tells him to kick her grandmother, Setu Jain (Taru Devani), out, but eventually warms to her support.

| Rishi Rian

| Kali's (Hiral Varsani) husband who loses his job.

| Taru Devani

| Kali Sanyal's (Varsani) grandmother who unexpectely arrives at her house to support her and Max Sanyal (Rian) with their new baby.

| 29 September

| Linda Armstrong{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Maeve Ludlow turn herself into the police? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-maeve-ludlow-turn-herself-into-the-police |access-date=20 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=23 September 2022 |archive-url=https://web.archive.org/web/20220923111955/https://www.whattowatch.com/spoilers/doctors-spoilers-will-maeve-ludlow-turn-herself-into-the-police |url-status=live }}

| A carer who takes on too much work. After feeling breathless and collapsing, she drags herself on the ground to the Mill, where she is seen by Zara Carmichael (Walsh). Zara tells her she must go into hospital for tests, but after she receives a call about a patient needing her assistance, she goes to help them instead.

| rowspan="6" | 30 September

| {{nowrap|Isaua Barbé-Brown{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Ex-EastEnders star Lucy Benjamin makes guest appearance |url=https://www.whattowatch.com/spoilers/doctors-spoilers-ex-eastenders-star-lucy-benjamin-makes-guest-appearance |access-date=20 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=23 September 2022 |archive-url=https://web.archive.org/web/20220923111959/https://www.whattowatch.com/spoilers/doctors-spoilers-ex-eastenders-star-lucy-benjamin-makes-guest-appearance |url-status=live }}}}

| A solicitor who helps Jan Fisher (Lucy Benjamin) to be freed after murdering her abusive husband.

| Christien Anholt

| Jan Fisher's (Benjamin) solicitor who gives her bad legal advice prior to her court trial.

| Miles Richardson

| The prosecution at Jan Fisher's (Benjamin) trial who gets her sent down for the murder of her abusive husband. He also undermines Emma Reid's (Miles) abilities as a doctor.

| Gracie Kelly

| The mistress of Jan Fisher's (Benjamin) dead husband, Mark. She initially slanders Jan in court and makes out that she was the abusive one in their marriage. However, Emma Reid (Miles) gets her to admit that Mark abused her too. She later stands in court and helps Jan to be freed.

| Paul Foulds

| The judge who presides over Jan Fisher's (Benjamin) court trial.

| {{nowrap|Linda John-Pierre}}

| Jan Fisher's (Benjamin) cellmate who, like her, was abused by her husband. She encourages Jan to appeal her sentencing and after Jan is released, she sets out to get justice for Mona.

| rowspan="2" | 3 October

| Oscar Curtis{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Jimmi Clay is DEVASTATED after Maeve's confession... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-jimmi-clay-is-devastated-after-maeves-confession |access-date=7 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=6 October 2022 |archive-url=https://web.archive.org/web/20221006164320/https://www.whattowatch.com/spoilers/doctors-spoilers-jimmi-clay-is-devastated-after-maeves-confession |url-status=live }}

| A teenager who became homeless after leaving his foster parents and becoming unable to keep up with his bills. He takes on the care of a stray chicken and when she falls ill, he visits Princess Buchanan (White) about it. She refuses to treat or give advice on a chicken, but notices that his arm is scratched and gives him a tetanus vaccine.

| Mark Flitton

| Finn Carson's (Oscar Curtis) former foster father who is contacted when Karen Hollins (Pearson) calls him about Finn leaving his phone at the Campus Surgery. He learns that Finn is homeless and takes him back into his house.

| {{nowrap|4 October–14 December}}

| Terry Mynott{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO accuses Emma Reid of being unprofessional? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-accuses-emma-reid-of-being-unprofessional |access-date=7 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=7 October 2022 |archive-url=https://web.archive.org/web/20221007202934/https://www.whattowatch.com/spoilers/doctors-spoilers-who-accuses-emma-reid-of-being-unprofessional |url-status=live }}

| A detective sergeant that undermines Emma Reid's (Miles) capability at her job. After the pair have a public confrontation, they make up over a coffee. Emma confides in him about living next door to Roxy Piper's (Skinner) brothel, but asks him not to get involved, to which he goes behind her back and has officers look into it. Matt then defends his colleague, Danny Field (Richard Crehan), when he allegedly assaults Tony Walsh (Stephen Thompson). After a ring from Danny's bag of evidence goes missing hours after seeing it, Emma suspects that Matt has interfered to make the case fall apart.

| rowspan="2" | 4 October

| Kwame Augustine

| rowspan="2" | A married couple and friends of Bear Sylvester (Lee). When Chanelle announces her pregnancy to Galton, he reels in horror as he realises that she has cheated on him, since he is infertile. He confronts her and the pair end their marriage.

| Whitney Kehinde

| {{nowrap|5–10 October}}

| {{nowrap|Issam Al Ghussain{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Scarlett Kiernan finds a NEW job |url=https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-finds-a-new-job |access-date=27 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=30 September 2022 |archive-url=https://web.archive.org/web/20220930200613/https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-finds-a-new-job |url-status=live }}}}

| A colleague of Scarlett Kiernan's (Pegg) when she gets a second job as a cleaner. Whilst moving a table to clean behind it, Scarlett notices that Yusuf's leg is bothering him. She gives him contact details for the Mill, where she works as a receptionist. When Scarlett finds Yusuf outside the Mill, she is relieved. However, when Valerie Pitman (Moyle) asks Yusuf lots of questions, he panics and runs away. Scarlett panics when Yusuf does not show up for his cleaning shift and does not answer the phone when she calls him. Yusuf's leg gets infected and Scarlett gets Sid Vere (Rice) to take a look at it. However, due to being undocumented and fearing he will be sent back to his country and killed, he leaves without a trace following Sid's treatment of his leg.

| {{nowrap|5–13 October}}

| Madeleine MacMahon

| The manager of Yusuf (Issam Al Ghussain) and Scarlett Kiernan (Pegg) at their cleaning job. After Scarlett expresses her disgust with how Frances treats people on zero-hour contracts and brands her a cow, she quits and leaves a mess all over the floor for Frances to clean up.

| rowspan="2" | 5 October

| Joy McAvoy

| A patient of Ruhma Carter's (Patel) who gives birth with the father of the baby, Ivan Speight (Peter Barrett). She is initially hesitant to form a romantic connection to him due to his shady business deals conflicting with her morals, but decides to put her beliefs aside and get with him.

| Peter Barrett

| A stockbroker who has various investments in shady businesses. Cassie Stredway (Joy McAvoy), his ex-girlfriend and mother to his child, disagrees with his involvement, so he sells the majority of his businesses.

| rowspan="3" | 6 October

| Steph Parry

| The mother of Ruby (Bethany Milner), a teenager with bulimia. Unable to pay the rent, she has routine sex with landlord Gavin Storey (Pablo Raybould), until Zara Carmichael (Walsh) threatens to expose him and get his landlord licence revoked.

| Bethany Milner

| A bulimic teenager who almost relapses after finding out her mother has been having sex with their landlord to get free rent.

| Pablo Raybould

| The landlord of Yasmin Jameson (Steph Parry) who takes advantage of her by having sex with her in replacement of her paying rent. When Yasmin's doctor, Zara Carmichael (Walsh) learns of his behaviour, she discovers he is an acquaintance of Daniel Granger's (Chambers). She presses him for information on Gavin and threatens to expose him.

| rowspan="3" | 7 October

| Chanel McKenzie{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Princess Buchanan shadows Jimmi at the police station |url=https://www.whattowatch.com/spoilers/doctors-spoilers-princess-buchanan-shadows-jimmi-at-the-police-station |access-date=27 September 2022 |work=What to Watch |publisher=(Future plc) |archive-date=30 September 2022 |archive-url=https://web.archive.org/web/20220930200613/https://www.whattowatch.com/spoilers/doctors-spoilers-princess-buchanan-shadows-jimmi-at-the-police-station |url-status=live }}

| A heroin-addicted patient of Jimmi Clay's (Morgan) who tries to con him into giving her drugs. She later presses Princess Buchanan (White) for drugs too, but is unsuccessful.

| Andy Hockley

| A patient of Jimmi Clay's (Morgan) who has been arrested for being drunk and disorderly. Princess Buchanan (White) uncovers that he was not drunk, but had instead fallen and gotten brain damage.

| Mikhael Deville

| The owner of a corner shop who stabs and murders a man trying to break into his business.

| rowspan="3" | 10 October

| Caroline O'Neill{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO gets arrested in Letherbridge? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-gets-arrested-in-letherbridge |access-date=7 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2022 |archive-url=https://web.archive.org/web/20221028210159/https://www.whattowatch.com/spoilers/doctors-spoilers-who-gets-arrested-in-letherbridge |url-status=live }}

| An English literature lecturer at Letherbridge University. Leon Collier (Tashinga Bepete), a student in her class, harasses and bothers her outside of work for extra help with his course. The stress leads to Miriam having a breakdown.

| Tashinga Bepete

| A student in Miriam Downing's English literature class. He harasses and bothers her for extra help outside of his lectures, leading to her eventual breakdown.

| Marnie Baxter

| The head of the English literature department at Letherbridge University.

| {{nowrap|11–18 October}}

| Lysette Anthony{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Ex-Hollyoaks star Lysette Anthony guests |url=https://www.whattowatch.com/spoilers/doctors-spoilers-ex-hollyoaks-star-lysette-anthony-guests |access-date=7 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2022 |archive-url=https://web.archive.org/web/20221028210204/https://www.whattowatch.com/spoilers/doctors-spoilers-ex-hollyoaks-star-lysette-anthony-guests |url-status=live }}

| An entrepreneur who expresses interest in investing in Valerie Pitman's (Moyle) business idea. She tries to underfund Valerie's venture until Princess Buchanan (White) exposes her falling profits, leading to Mary increasing her offer by 10 times the amount.

| rowspan="3" | 11 October

| Katie Pattinson

| A woman with dissociative identity disorder. Karen Hollins (Pearson) is initially confused and worried by her various personalities until Remy explains it to her and goes for help at the Mill.

| Martin Chamberlain

| rowspan="2" | Two of Remy Lazenby's (Katie Pattinson) personalities mentally speaking to her.

| Heloise Spring

| rowspan="3" | 12 October

| David Sterne{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Daniel Granger uncovers some family secrets... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-uncovers-some-family-secrets |access-date=7 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2022 |archive-url=https://web.archive.org/web/20221028210201/https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-uncovers-some-family-secrets |url-status=live }}

| rowspan="3" | A family-run funeral home. Daniel Granger (Chambers) attempts to help them through a family rivalry.

| Rowan Polonski

| Gavin Brocker

| rowspan="2" | 13 October

| Danielle Walters{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Scarlett Kiernan gets SACKED! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-gets-sacked |access-date=7 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2022 |archive-url=https://web.archive.org/web/20221028210202/https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-gets-sacked |url-status=live }}

| An employee of Frances Holman's (Madeleine MacMahon) who has her shift taken away after her bus is late. Scarlett Kiernan (Pegg) stands up for her and the other workers on zero-hour contracts and quits, giving her shift to Gill.

| Benjamin Teare

| A delivery driver who takes samples from the Mill to a laboratory. He reveals that he suffers from panic attacks in settings with ambulances.

| rowspan="3" | 14 October

| Michelle Holmes{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Valerie Pitman and Al strike a deal? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-valerie-pitman-and-al-strike-a-deal |access-date=7 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2022 |archive-url=https://web.archive.org/web/20221028210200/https://www.whattowatch.com/spoilers/doctors-spoilers-will-valerie-pitman-and-al-strike-a-deal |url-status=live }}

| The wife of Simon Booth (Phil McKee), whose father has recently died. She reveals to Phil that she has been having an affair with Stevie Dutch (Deborah Sekibo), and when she calls Stevie to say that they should be together properly, she gets rejected.

| Phil McKee

| The husband of Dora Booth (Michelle Holmes) who is grieving after the death of his father. Dora reveals that she has been having an affair with her best friend behind his back.

| Deborah Sekibo

| A married woman who has an affair with Dora Booth (Holmes). When Dora suggests being together properly, Stevie rejects her and explains that she values her wife and kids more than her.

| rowspan="2" | 17–18 October

| Stephen Thompson{{cite web |title=Everyone Has Something |url=https://www.bbc.co.uk/programmes/m001d80t |publisher=BBC |access-date=29 October 2022 |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030121125/https://www.bbc.co.uk/programmes/m001d80t |url-status=live }}

| A man who begins a relationship with Danny Field's (Crehan) ex-partner. The two have an altercation and Tony alleges that Danny assaulted him.

| Richard Crehan

| A police officer and friend of DS Matt Cassidy's (Terry Mynott). After Tony Walsh (Thompson) gets with his ex-partner, the two have an altercation and Tony alleges that Danny assaulted him.

| rowspan="2" | 17 October

| Saikat Ahamed

| rowspan="2" | Two therapists that help Ruhma Carter (Patel) and Bear Sylvester (Lee) to overcome their phobias.

| {{nowrap|Anthea Harper-Rafferty}}

| rowspan="3" | 18 October

| James Merry{{cite web |title=The Girl After |url=https://www.bbc.co.uk/programmes/m001d7zl |publisher=BBC |access-date=29 October 2022 |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030121126/https://www.bbc.co.uk/programmes/m001d7zl |url-status=live }}

| A man who goes to speak at Letherbridge University, until lecturer Gemma Swinton (Rebecca Grant) exposes him for being a serial rapist.

| Rebecca Grant

| A lecturer at Letherbridge University who suffers from a panic attack when she comes into contact with a man who raped her, Phil Bradbury (James Merry).

| Sam Coulson

| A colleague of Gemma Swinton's (Grant).

| rowspan="3" | 19 October

| Carolyn Lyster{{cite web |title=Thank You for Your Service |url=https://www.bbc.co.uk/programmes/m001d825 |publisher=BBC |access-date=29 October 2022 |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030121125/https://www.bbc.co.uk/programmes/m001d825 |url-status=live }}

| A patient of Sid Vere's (Rice) who asks him to get shopping for her due to having no food and no support. Since he pities her situation, he stays with her for the evening.

| Douglas Dawson

| A mentally ill patient of Sid Vere's (Rice) who believes that after being the random victim of a mugging, a group of people are out to get him. Sid has him sectioned.

| Livvi Parsons

| A young carer who contemplates leaving her mother due to wanting more for herself. Sid Vere (Rice) helps her to take better care of herself.

| rowspan="2" | {{nowrap|20 October–2 November}}

| Katy Sobey{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Emma Reid confronts DS Matt Cassidy... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-emma-reid-confronts-ds-matt-cassidy |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030121126/https://www.whattowatch.com/spoilers/doctors-spoilers-emma-reid-confronts-ds-matt-cassidy |url-status=live }}

| rowspan="2" | A couple who see Al Haskey (Midlane) about Noah, their son, since he has a fever and a rash. Al examines Noah and assures the couple there is nothing serious to worry about, but as they are about to leave, Al notices from medical records that Noah has not been given his 8-week vaccination. Al asks why and Simon rants about his anti-vaxx views, while Dawn is silent. Al explains the benefits of vaccinations for children as young as Noah, as well as informing them on the harms of not having vaccines. Dawn later takes Noah in for his vaccine in without telling Simon. When Simon notices a small mark on Noah's ankle from the vaccine, he takes him in to see Al, who tells him about Noah's vaccine, to which Simon flies into a rage. He makes an official complaint against Al and calls NHS England to report him. He also makes a video on social media about Al, despite Al affirming that he had parental consent from Dawn. However, after his marriage breaks down due to the conflict, he attends a discussion about vaccinations led by Al, where he finds Dawn. The pair reconcile their marriage and he agrees to not let his personal beliefs affect their family.

| Christopher Harper

| rowspan="2" | 20 October

| Kaysha Woollery

| A pregnant patient of Ruhma Carter's (Patel). Princess Buchanan (White) shadows Ruhma whilst she handles Chantelle's birthing experience and she is shocked to learn that Princess dated her partner and the father of the baby, Nathan Harris (Cory Chambers), when the pair were in school.

| Cory Chambers

| The partner of Chantelle Fry (Kaysha Woollery) and the father of her baby. He is shocked to learn that Princess Buchanan (White) is shadowing their birth experience, since he dated her in school.

| rowspan="4" | 21 October

| James Vaughan{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Zara Carmichael confronts a MYSTERY intruder! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-zara-carmichael-confronts-a-mystery-intruder |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030121125/https://www.whattowatch.com/spoilers/doctors-spoilers-zara-carmichael-confronts-a-mystery-intruder |url-status=live }}

| The father of Annie (Peta Cornish). After his wife died, he forced Annie to marry him whilst she was underaged. He raped her and forced her to birth a child together, Lucy (Hattie Gotobed). His crimes are discovered by Sid Vere (Rice) when he goes out to tend to Mal's injuries on his farm.

| Peta Cornish

| The daughter of Mal (James Vaughn). After her mother died, Mal forced Annie to marry him whilst she was underaged. He raped her and forced her to birth a child together, Lucy (Gotobed). She tells Sid Vere (Rice) about his crimes and he helps to free herself and Lucy.

| Hattie Gotobed

| The incestual daughter of Mal (Vaughn) and Lucy (Cornish). She has never experienced life outside of their farm until Mal's crimes are discovered and herself and Lucy are freed.

| Claudia Cadette

| A social worker who is designated to Annie (Cornish) and Lucy Wakefield (Gotobed) after Mal Wakefield's (Vaughn) incest and sexual offences are discovered.

| rowspan="3" | 24 October

| Shaun Blackstock{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO do Daniel Granger and Zara argue about? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-do-daniel-granger-and-zara-argue-about |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030143313/https://www.whattowatch.com/spoilers/doctors-spoilers-who-do-daniel-granger-and-zara-argue-about |url-status=live }}

| The teacher of Jay Bowden (Oliver Cunliffe) whose mother feels that he is getting too involved by caring for Jay's welfare.

| Oliver Cunliffe

| A school student whose mother, Fiona (Lainy Boyle), struggles to financially provide for the both of them.

| Lainy Boyle

| The mother of Jay (Cunliffe) who works numerous jobs and visits food banks to provide for the pair.

| rowspan="2" | 25 October

| Jess Conrad{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHY is Al Haskey in BIG trouble? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-al-haskey-in-big-trouble |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030143316/https://www.whattowatch.com/spoilers/doctors-spoilers-why-is-al-haskey-in-big-trouble |url-status=live }}

| An elderly man who is tricked by DS Tony Bale (Simon Cotton) into thinking his house is being used for surveillance. Tony gets Alan to contact him whenever he sees a woman who he believes to be a suspect, but is really Tony's wife who walked out on him and moved across the road from Alan.

| Simon Cotton

| A detective sergeant who tricks Alan Yates (Jess Conrad) into thinking his house is being used for surveillance. He gets Alan to contact him whenever he sees a woman who he told Alan is a suspect, but is really Tony's wife who walked out on him and moved across the road from Alan.

| rowspan="2" | 26 October

| Steph Lacey{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Bear Sylvester tries to help a patient with life changing issues... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-tries-to-help-a-patient-with-life-changing-issues |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030143314/https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-tries-to-help-a-patient-with-life-changing-issues |url-status=live }}

| A woman who has been in a wheelchair for two years due to a collapsing from a medical condition that doctors cannot diagnose. She visits the Mill and is disgusted by Scarlett Kiernan (Pegg) telling her that she cannot walk into an appointment without booking it and she tells Bear Sylvester (Lee) that she wants to put in a complaint about her. Bear befriends her and introduces her to balloon therapy, later helping her to leave her controlling girlfriend, Sarah Taylor (Edie Newman).

| Edie Newman

| The controlling girlfriend of Vicky Bishop (Steph Lacey). When she learns that Bear Sylvester (Lee) has suggested therapy to Vicky, Sarah threatens him that she will put in a complaint against him since he has no medical qualifications. When he informs Vicky of Sarah's behaviour, she dumps Sarah.

| rowspan="4" | 27 October

| Karly Maguire{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Daniel Granger send Izzie to private school? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-daniel-granger-send-izzie-to-private-school |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=30 October 2022 |archive-url=https://web.archive.org/web/20221030143315/https://www.whattowatch.com/spoilers/doctors-spoilers-will-daniel-granger-send-izzie-to-private-school |url-status=live }}

| A fine art student at Letherbridge University. She invites John 'Lump' Lavenham (Liam Elcock) into her flat as a housemate and the pair form a romantic connection.

| Chiarina Woodall

| Alice Smith's (Karly Maguire) housemate who tries to have sex with Lump (Elcock) after she notices that Alice and Lump have a connection. She tells Alice that she did it since Alice is always too nice, to which Alice responds by throwing Liz out.

| Liam Elcock

| A student at Letherbridge University who forms a connection with housemate Alice Smith (Maguire).

| Adetokunbo Allen

| The headteacher of Ravenford, a private school that Joe Granger Carmichael (Oliver Falconer) attends. Daniel (Chambers) sends Izzie Torres (Moore) for a meeting there to see if she can attend, but after she tells Mr Percy that she does not like the elitist nature of his school, he refuses to allow her to attend.

| {{nowrap|28 October, 2 November}}

| Jennifer Nicholas

| A patient of Sid Vere's (Rice) who agrees with Simon Richeson's (Christopher Harper) anti-vaccination comments on social media.

| rowspan="3" | 28 October

| D'Nico Greaves

| A teenager who steals the purse of his landlord, Aileen McAllister (Jemma Churchill), since she allows him and his father to live in poor conditions.

| Garry Robson

| The disabled father of Ethan Rowe (D'Nico Greaves).

| Jemma Churchill

| A landlord who has allowed Mick Rowe (Garry Robson) to live in poor conditions such as damp walls. His son, Ethan (Greaves), steals her purse.

| rowspan="3" | 31 October

| Dominic Jones{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Halloween HORROR in Letherbridge! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-halloween-horror-in-letherbridge |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=1 November 2022 |archive-url=https://web.archive.org/web/20221101075810/https://www.whattowatch.com/spoilers/doctors-spoilers-halloween-horror-in-letherbridge |url-status=live }}

| A homeless man who was abused by his parents. He recounts his stories of abuse at a homeless resource centre organised by Jonquil Heathcote (Rebecca Saire). There, he meets his brother, Owen (Matt Pettifor), who has been searching for him at shelters for years.

| Matt Pettifor

| Mark's (Dominic Jones) brother whose parents forced him to join in with their abuse of Mark. He searches for Mark for years at homeless shelters and eventually finds him, where he apologises.

| Rebecca Saire

| An events organiser who puts together a centre for homeless people to gather resources and seek medical advice. After she stresses over small aspects of the event not coming together, she admits to Sid Vere (Rice) that she is an alcoholic. He arranges for her to get help with recovery at the Mill.

| rowspan="2" | 1 November

| Ali Craig{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Daniel Granger is in DANGER! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-is-in-danger |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 November 2022 |archive-url=https://web.archive.org/web/20221105080310/https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-is-in-danger |url-status=live }}

| A criminal who holds Lee Webber (Matthew Hawksley) hostage to perform an illegal job with him. After inflicting damage on Lee's leg, he demands medical attention and they call Daniel Granger (Chambers). He attacks Daniel who later escapes and calls the police, who eventually find Fraser.

| Matthew Hawksley

| A man held hostage and attacked by Fraser Monroe (Ali Craig).

| rowspan="4" | 2 November

| Cael King{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Al Haskey is at the centre of vaccine CONSPIRACY THEORIES! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-is-at-the-centre-of-vaccine-conspiracy-theories |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 November 2022 |archive-url=https://web.archive.org/web/20221105080314/https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-is-at-the-centre-of-vaccine-conspiracy-theories |url-status=live }}

| An undercover police officer who uncovers Marsha Kelly's (Sianad Gregory) human trafficking schemes. Due to the trauma of finding people dead, he feels unready to start a family with wife Shivani (Sharan Phull).

| Sharan Phull

| Arjan Jhutti's (Cael King) wife who wants IVF until Arjan confides in her about his trauma over finding people dead in his job.

| Sianad Gregory

| The leader of a human trafficking ring.

| James Duke

| A conspiracy theorist at Al Haskey's (Midlane) and Ruhma Carter's (Patel) discussion about vaccinations. Al humiliates him by proving his theories wrong with science.

| 3 November

| Andrew Paul{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Valerie Pitman gets Izzie smiling again |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-gets-izzie-smiling-again |access-date=29 October 2022 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2022 |archive-url=https://web.archive.org/web/20221028210203/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-gets-izzie-smiling-again |url-status=live }}

| A patient of Jimmi Clay's (Morgan) who struggles with violent nightmares where he is attempting to kill his son.

| rowspan="3" | 7–8 November

| Phil Nice{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: ROMANCE for Ruhma Carter? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-romance-for-ruhma-carter |access-date=15 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151245/https://www.whattowatch.com/spoilers/doctors-spoilers-romance-for-ruhma-carter |url-status=live }}

| An elderly man with dementia who wanders onto his neighbour's building site in search of his cat who died 30 years prior.

| Sam Callis

| Geoffrey Parsons' (Phil Nice) neighbour.

| Sabina Franklyn

| Geoffrey's (Nice) wife who argues with Kevin Topley (Sam Callis) after she misinterprets him helping Geoffrey for hurting him.

| 7 November

| Ruby Hoggarth

| A case worker who is questioned by Brian Kiernan (Simon Lowe) due to feeling that he is not receiving enough Universal Credit.

| {{nowrap|8–18 November}}

| Amerjit Deu

| A man who Ruhma Carter (Patel) meets for a date after they connect via a dating website. After he gets drunk on their first date and embarrasses himself, he turns up at the Mill with flowers and apologises to Ruhma. He asks her on a second date where he remains sober and kisses her on the cheek.

| rowspan="4" | 9 November

| Matilda Bailes{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Al Haskey gives an interview about vaccinations |url=https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-gives-an-interview-about-vaccinations |access-date=15 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151255/https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-gives-an-interview-about-vaccinations |url-status=live }}

| A fashion designer who, after releasing looks anonymously for years, decides to open up about her real identity after a push from her favourite doctor, Princess Buchanan (White).

| Alexandra Mathie

| Alex Evans' (Matilda Bailes) demanding boss who is shocked to learn that she is a critically acclaimed fashion designer.

| Bhawna Bhawsar

| A journalist who interviews Al Haskey (Midlane) on his pro-vaccination stance.

| Jane Cunliffe

| Alex's (Bailes) mother who wants her to have a stable career.

| rowspan="2" | 10 November

| Pearse Egan{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Can Daniel Granger find a way to deal with daughter Izzie? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-daniel-granger-find-a-way-to-deal-with-daughter-izzie |access-date=15 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151247/https://www.whattowatch.com/spoilers/doctors-spoilers-can-daniel-granger-find-a-way-to-deal-with-daughter-izzie |url-status=live }}

| An overweight patient of Emma Reid's (Miles). She advises Ian that if he wants to better his life opportunities, he should make lifestyle changes. Hours later, he has a heart attack and dies.

| Emma Noakes

| Ian's (Pearse Egan) wife who initially does not believe that he has died due to the shock of her grief.

| rowspan="3" | 11 November

| Warren Donnelly{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Izzie Torres ruin a family day out? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-izzie-torres-ruin-a-family-day-out |access-date=15 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151256/https://www.whattowatch.com/spoilers/doctors-spoilers-will-izzie-torres-ruin-a-family-day-out |url-status=live }}

| A petty thief who takes advantage of PC Gareth Lewis' (Samuel Morgan-Davies) naivety surrounding criminality.

| David Omordia

| A famous footballer who is approached by Daniel Granger (Chambers) for a selfie at a golf club.

| Nellie Fogarty

| Arlo Jennings' (David Omordia) ex-partner who informs him that she wants to raise their child alone until he decides he wants to be involved.

| rowspan="3" | 14 November

| Will Bliss{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Ruhma Carter have another dating DISASTER? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-ruhma-carter-have-another-dating-disaster |access-date=15 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151255/https://www.whattowatch.com/spoilers/doctors-spoilers-will-ruhma-carter-have-another-dating-disaster |url-status=live }}

| A teacher with long COVID who struggles mentally with his recovery. Feeling that he will not get better, he abruptly ends his relationship with girlfriend Katya Milton (Jessica Hardwick), who storms in on his counselling session with Jimmi Clay (Morgan).

| Jessica Hardwick

| Matt Dowding's (Will Bliss) girlfriend who salvages their relationship.

| Christopher Parkinson

| A waiter at a restaurant that Ruhma Carter (Patel) and Suhaan Begum (Amerjit Deu) have their second date at.

| rowspan="2" | {{nowrap|15 November–15 December}}

| Caoimhe Farren{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Daniel Granger makes an ALARMING discovery... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-makes-an-alarming-discovery |access-date=20 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151245/https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-makes-an-alarming-discovery |url-status=live }}

| The mother of severe asthmatic Grace (Lacey Leigh Payne). She tells Valerie Pitman (Moyle) and Scarlett Kiernan (Pegg) that there is a medication that would help Grace, but the Mill cannot afford it. After Scarlett expresses her disgust with the system, Valerie promises a skeptical Hailey that she will do something about it. Days later, Valerie surprises Hailey with the medication.

| Lacey Leigh Payne

| The severely asthmatic daughter of Hailey (Caoimhe Farren). After Valerie gets her expensive medication by forging Al Haskey's (Midlane) signature, her health widely improves.

| rowspan="3" | 15 November

| Danny Murphy

| A deaf teenager in the care of Jez Appleby (Nigel Pilkington). After he causes a public fire burning all of Jez's prizes and awards for his care work, he confides in Gareth Lewis (Morgan-Davies) that Jez has been sexually abusing him.

| Nigel Pilkington

| A care worker who is arrested for sexually abusing Rory Morgan (Danny Murphy).

| Katie Erich

| An interpreter for Rory Morgan (Murphy).

| rowspan="2" | 16 November

| Verity Marshall{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO tries to impress Zara, Daniel and Bear? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-tries-to-impress-zara-daniel-and-bear |access-date=20 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151256/https://www.whattowatch.com/spoilers/doctors-spoilers-who-tries-to-impress-zara-daniel-and-bear |url-status=live }}

| rowspan="2" | A married couple who are unprepared for the birth of their child. Midwife Ruhma Carter (Patel) presses them for decisions and Carrie explains that their lack of preparation is due to Carrie being raped and the baby not being Andy's.

| Ben Deery

| rowspan="4" | 17 November

| Shelley Draper{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Al Haskey has SHOCK NEWS for a married couple... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-has-shock-news-for-a-married-couple |access-date=20 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151247/https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-has-shock-news-for-a-married-couple |url-status=live }}

| A taxi driver Al Haskey's (Midlane) who wants a fit note due to falling asleep behind the wheel and not wanting to lose her job.

| Lorna Durham

| rowspan="2" | A couple about to get married until Leo suggests that Sasha has a check-up appointment with Al Haskey (Midlane) due to feeling ill. Tests later reveal that Sasha is dying and Al suggests that they live happily together while they still can.

| Scott Gutteridge

| Paul Ridley

| A patient of Al Haskey's (Midlane) who had cancer.

| rowspan="3" | 18 November

| Liz Whiting{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Is Princess Buchanan in BIG trouble... again? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-is-princess-buchanan-in-big-trouble-again |access-date=20 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=20 November 2022 |archive-url=https://web.archive.org/web/20221120151248/https://www.whattowatch.com/spoilers/doctors-spoilers-is-princess-buchanan-in-big-trouble-again |url-status=live }}

| The wife and carer of Dennis (Malcolm Ward), who has dementia. With poor mobility, arthritis, declining eyesight and injuries herself, Karen Hollins (Pearson) arranges for the pair to get more support.

| Malcolm Ward

| The husband of Sally (Liz Whiting) who has dementia.

| Frankie Williams

| Sally (Whiting) and Dennis Harrison's (Ward) neighbour who is disrupted by their noise.

| rowspan="3" | 22 November

| Shoshana Jones{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: PC Gareth Lewis wants to QUIT! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-pc-gareth-lewis-wants-to-quit |access-date=22 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=22 November 2022 |archive-url=https://web.archive.org/web/20221122233955/https://www.whattowatch.com/spoilers/doctors-spoilers-pc-gareth-lewis-wants-to-quit |url-status=live }}

| A teenager with undiagnosed ADHD who takes her brother's ADHD medication.

| Connor Catchpole

| Holly's (Shoshana Jones) brother with ADHD. No longer wanting to take his medication, he gives it to Holly who feels that she has undiagnosed ADHD.

| Emma McMorrow

| Holly (Jones) and Josh's (Connor Catchpole) mother who gets told that as well as Josh having ADHD, Holly and herself may have it too.

| {{nowrap|22–23 November}}

| Kieran Boon{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHO catches Izzie Torres with her SECRET boyfriend? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-catches-izzie-torres-with-her-secret-boyfriend |access-date=22 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=22 November 2022 |archive-url=https://web.archive.org/web/20221122233955/https://www.whattowatch.com/spoilers/doctors-spoilers-who-catches-izzie-torres-with-her-secret-boyfriend |url-status=live }}

| Izzie Torres' (Moore) boyfriend. Her father, Daniel Granger (Chambers), is shocked to find them kissing and he asks Lee to leave. He searches for Lee on social media and is disgusted to learn that Lee is 18, since Izzie is 15.

| rowspan="3" | 22 November

| Patrick Dineen

| The son of problematic politician Fiona (Kate Kordel). When a scandal is published about her, Ty advises her to come clean but

| Kate Kordel

| A politician who is exposed by her son, Ty (Patrick Dineen), during a public scandal. In an attempt to cover up the truth, she lies to the media by claiming he suffers from substance abuse.

| Jada-Li Warrican

| Ty Martin's (Dineen) girlfriend who is shocked to learn he is the son of a corrupt politician. She advises him to expose his mother's crimes.

| rowspan="4" | 23 November

| Katheyn Delaney{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Scarlett Kiernan has a GUILTY secret! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-has-a-guilty-secret |access-date=23 November 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205164348/https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-has-a-guilty-secret |url-status=live }}

| rowspan="2" | Friends and patients of Al Haskey (Midlane) who protest benches in Letherbridge parks being removed by police officers. When Jenny falls ill mid-protest, Hector has to contact Al, who gets her taken into St. Phils.

| David Webber

| Steve Paget

| A man contracted by the police to remove park benches in Letherbridge.

| Richie Bratby

| A notorious criminal in Letherbridge. DS Matt Cassidy (Mynott) finds him smoking a cigarette after a corner shop robbery and assumes he stole them whilst robbing the shop. He aggravates Artie, who tries to break free from him, to which Matt claims Artie has assaulted a police officer and arrests him. In his interview, he affirms that he did not assault Matt.

| rowspan="2" | 24 November

| {{nowrap|Bethan Rose Young{{cite web |title=Still Too Soon to Know |url=https://www.bbc.co.uk/programmes/m001fjgg |publisher=BBC |access-date=5 December 2022 |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205164349/https://www.bbc.co.uk/programmes/m001fjgg |url-status=live }}}}

| A patient of Ruhma Carter's (Patel) who wants an abortion since she does not love Kev Gates (Cavan Clarke). Princess Buchanan (White) books her in for a termination without asking Ruhma.

| Cavan Clarke

| Ellie Forshaw's (Bethan Rose Young) partner.

| rowspan="3" | 25 November

| Lamin Touray{{cite web |title=The Brave |url=https://www.bbc.co.uk/programmes/m001fjk0 |publisher=BBC |access-date=5 December 2022 |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205164347/https://www.bbc.co.uk/programmes/m001fjk0 |url-status=live }}

| A soldier who confides in girlfriend Laura Harrison (Elizabeth Green) that he is being bullied by his colleagues.

| Elizabeth Green

| Luke Jackson's (Lamin Touray) girlfriend who is excited to have him home from war.

| Gwion Glyn

| Laura Harrison's (Touray) friend who realises her boyfriend is being bullied at work.

| rowspan="3" | 29 November

| Lauren Soley{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Valerie Pitman BREAKS THE RULES! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-breaks-the-rules |access-date=5 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205164349/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-breaks-the-rules |url-status=live }}

| rowspan="3" | Three colleagues from an office who attend Bear Sylvester's (Lee) conflict resolution course. Dani discovers that Iain and Janette have been having an affair and planning to make her redundant, after which she decides to report them.

| {{nowrap|Paul Courtenay Hyu}}

| Flaminia Cinque

| {{nowrap|29 November–14 December}}

| {{nowrap|Larner Wallace-Taylor{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Jimmi Clay investigates a rape accusation... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-jimmi-clay-investigates-a-rape-accusation |access-date=5 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205164348/https://www.whattowatch.com/spoilers/doctors-spoilers-jimmi-clay-investigates-a-rape-accusation |url-status=live }}}}

| A rape victim who gets pushed by DS Matt Cassidy (Mynott) to press charges against rapist Nicholas Thorne (Jamie Satterwaite). After she confides in partner Scott Watson (Liam Doyle) and he concludes that she cheated on him, she is again distraught to hear that her case will not be taken to court. She then attempts to kill herself, ending up in hospital.

| rowspan="2" | 29–30 November

| Jamie Satterwaite

| A man who raped Melissa Grant (Larner Wallace-Taylor) after a night out with her, as well as having prior accusations of rape.

| Liam Doyle

| Melissa Grant's (Wallace-Taylor) partner who does not believe that she was raped, instead concluding that it was consensual and that she intentionally cheated on him.

| 30 November

| Andrew Cullum{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: DS Matt Cassidy is determined to convict rape suspect Nicholas Thorne... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-ds-matt-cassidy-is-determined-to-convict-rape-suspect-nicholas-thorne |access-date=5 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205164352/https://www.whattowatch.com/spoilers/doctors-spoilers-ds-matt-cassidy-is-determined-to-convict-rape-suspect-nicholas-thorne |url-status=live }}

| An FME assessor at Letherbridge Police Station.

| 1 December

| Nathalie Pownall{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Princess Buchanan gets a MYSTERY phonecall! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-princess-buchanan-gets-a-mystery-phonecall |access-date=5 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=25 November 2022 |archive-url=https://web.archive.org/web/20221125203700/https://www.whattowatch.com/spoilers/doctors-spoilers-princess-buchanan-gets-a-mystery-phonecall |url-status=live }}

| A patient of Jimmi Clay's (Morgan) who he finds having a breakdown in a corner shop. He takes her into the Mill, where she explains that she is mourning the death of her goldfish.

| rowspan="3" | 2 December

| Katie Wimpenny{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Valerie Pitman get found out? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-valerie-pitman-get-found-out |access-date=5 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205164350/https://www.whattowatch.com/spoilers/doctors-spoilers-will-valerie-pitman-get-found-out |url-status=live }}

| A supervisor of a community payback scheme in Letherbridge. She tries to get Cal Cuthbert (Atlas Azure) and girlfriend Natalie Wilson (Evie Hargreaves) in trouble with the police, but her antics are filmed by Scarlett Kiernan (Pegg), who threatens to expose her on social media if she does not make it right.

| Atlas Azure

| A rapper who becomes famous on social media after a fight in a clothing store orchestrated by girlfriend Natalie Wilson (Hargreaves).

| Evie Hargreaves

| Cal Cuthbert's (Azure) girlfriend who acts as his manager by getting him famous on social media.

| rowspan="3" | 5 December

| Emma Robotham-Hunt{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Scarlett Kiernan celebrates her 21st birthday! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-celebrates-her-21st-birthday |access-date=5 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205190101/https://www.whattowatch.com/spoilers/doctors-spoilers-scarlett-kiernan-celebrates-her-21st-birthday |url-status=live }}

| rowspan="2" | Two of Scarlett Kiernan's (Pegg) friends who take her for a surprise night out on her 21st birthday. After Scarlett slaps ex-boyfriend Ryan Roper (Jack Heath) for sexually assaulting her in a nightclub, the owners call the police on them. Scarlett goes to the station wearing Tamzin's coat, the pocket of which has ketamine in. Scarlett is arrested for possession of Drugs controlled by the UK Misuse of Drugs Act until Tamzin admits they are hers.

| Amy Murphy

| Jack Heath

| Scarlett Kiernan's (Pegg) ex-boyfriend who cheated on her with one of her friends. When he sees her in a nightclub for her 21st birthday, he sexually assaults her. In response, she slaps him and gets him thrown out of the club.

| rowspan="9" | 6 December

| Joshua Vaughan{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Is Princess Buchanan about to get SACKED? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-is-princess-buchanan-about-to-get-sacked |access-date=6 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=6 December 2022 |archive-url=https://web.archive.org/web/20221206160318/https://www.whattowatch.com/spoilers/doctors-spoilers-is-princess-buchanan-about-to-get-sacked |url-status=live }}

| A school student who is interested in joining the police after school despite having a criminal father, Dave Prentice (Matthew Stathers). When Dave assaults his brother, he tells the police and gets him arrested.

| Oscar Weir

| The brother of Aidan Kemp (Joshua Vaughan) who initially wants to join their father's illegal business until Joshua gets him arrested for assaulting Jack.

| Matthew Stathers

| The father of Aidan Kemp (Vaughan) and Jack Prentice (Weir) who has recently been released from prison after an eight-year sentence. Once out, he continues running his business of stealing cars and he beats Jack up, which Aidan gets him arrested for.

| Aaron Virdee

| A pharmacist who phones the Mill after noticing the fraudulent prescription Valerie Pitman (Moyle) made for Grace Dodds (Payne).

| Nicola Chegwin{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: DS Matt Cassidy finds a MYSTERY new witness... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-ds-matt-cassidy-finds-a-mystery-new-witness |access-date=6 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=6 December 2022 |archive-url=https://web.archive.org/web/20221206160320/https://www.whattowatch.com/spoilers/doctors-spoilers-ds-matt-cassidy-finds-a-mystery-new-witness |url-status=live }}

| A terminally ill patient of Sid Vere's (Rice). Before telling daughter Stella (Kirsty MacLaren) that she is set to die soon, she introduces her to grandfather Terry Dawlish (William Brand).

| Kirsty MacLaren

| Hazel's (Nicola Chegwin) daughter who is horrified to learn that her mother is set to die soon, instead of the ten further years she believed she had left. She is also shocked to meet her grandfather, Terry Dawlish (Brand).

| Sofiya Limalia

| A woman who was involved with DS Matt Cassidy (Mynott) in the past who comes forward as a surprise witness for the case involving Melissa Grant's (Wallace-Taylor) rape. Rob Hollins (Walker) suspects that she is being coerced by Matt and later sees them talking together in private.

| William Brand

| The father of Hazel Jacklin (Chegwin) who lost contact with her when she became pregnant as a teenager. The pair reconcile their relationship when Hazel learns that she is dying.

| Saffron Davies

| Izzie Torres' (Moore) friend who attended her house party.

| rowspan="3" | 7 December

| Phillip Browne{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Zara Carmichael hears a CONFESSION from Izzie... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-zara-carmichael-hears-a-confession-from-izzie |access-date=15 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=15 December 2022 |archive-url=https://web.archive.org/web/20221215113331/https://www.whattowatch.com/spoilers/doctors-spoilers-zara-carmichael-hears-a-confession-from-izzie |url-status=live }}

| Bear Sylvester's (Lee) former maths teacher. He is enraged when his gay son is not allowed to donate blood.

| Mukeni Nel

| A gay student and friend of Bear Sylvester's (Lee) who comes out to father Oscar (Phillip Browne) after years of trying. He is shocked to learn that Oscar has known for years.

| Noel Sullivan

| A blood donor nurse who tells Tyler Baxter (Mukeni Nel) that due to rules set out to protect people, he cannot donate blood due to not being in a long-term exclusive relationship.

| rowspan="3" | 8 December

| Lucy Black{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Ruhma Carter meets three grieving strangers at the graveyard |url=https://www.whattowatch.com/spoilers/doctors-spoilers-ruhma-carter-meets-three-grieving-strangers-at-the-graveyard |access-date=15 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=15 December 2022 |archive-url=https://web.archive.org/web/20221215113336/https://www.whattowatch.com/spoilers/doctors-spoilers-ruhma-carter-meets-three-grieving-strangers-at-the-graveyard |url-status=live }}

| rowspan="2" | The mothers of two children who died in a bus crash caused by driver Graeme Wilkes (James Quinn) falling asleep whilst driving due to his narcolepsy. While Kitty holds a lifelong grudge against Graeme, Sandra forgave him and they began a relationship, until he accidentally reveals that he knew of his narcolepsy prior to driving the bus.

| Buffy Davis

| James Quinn

| A former bus driver who was responsible for the deaths of several children due to falling asleep at the wheel from narcolepsy.

| rowspan="3" | 9 December

| Katy Poulter{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO is Princess Buchanan trying to avoid? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-is-princess-buchanan-trying-to-avoid |access-date=15 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=15 December 2022 |archive-url=https://web.archive.org/web/20221215113336/https://www.whattowatch.com/spoilers/doctors-spoilers-who-is-princess-buchanan-trying-to-avoid |url-status=live }}

| rowspan="2" | A married couple who are torn apart when Tim gets diagnosed with chlamydia. He reveals to Becky that he did sexual acts with her sister, Mia Kirk (Francesca Marie Claire), when they were away together.

| Ashley Joseph

| {{nowrap|Francesca Marie Claire}}

| Becky Stuart's (Katy Poulter) sister who has been living with her and Becky's husband, Tim (Ashley Joseph). Becky kicks her out once Tim reveals that they did sexual acts together.

| rowspan="4" | 12 December

| Polly Maberly{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: A SURPRISE marriage proposal goes terribly wrong! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-a-surprise-marriage-proposal-goes-terribly-wrong |access-date=15 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=15 December 2022 |archive-url=https://web.archive.org/web/20221215113333/https://www.whattowatch.com/spoilers/doctors-spoilers-a-surprise-marriage-proposal-goes-terribly-wrong |url-status=live }}

| The heavily pregnant partner of cardiac surgeon Gregory Painter (Bo Poraj) who plans to propose to him after 20 years of being together. She plans a surprise party to engage to him at, which after giving birth at, she does.

| Helena Little

| Gregory Painter's (Poraj) medical secretary who helps his partner to plan a surprise party to engage to him at.

| Bo Poraj

| A cardiac surgeon who proposed to partner Charlotte Simms (Polly Maberly) 20 years prior at his concert, to which she said no. After giving birth to their child at a surprise party she has planned, she proposes to Gregory, who accepts.

| Gina Murray

| A vocal coach who trains Gregory Painter (Poraj) to regain his confidence when singing.

| 15 December

| Darren Bancroft{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will someone get SACKED? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-someone-get-sacked |access-date=15 December 2022 |work=What to Watch |publisher=(Future plc) |archive-date=15 December 2022 |archive-url=https://web.archive.org/web/20221215143859/https://www.whattowatch.com/spoilers/doctors-spoilers-will-someone-get-sacked |url-status=live }}

| A man dining in the Icon waiting for his wife. Scarlett Kiernan (Pegg) and Al Haskey (Midlane) notice how rude he is being to his server and reprimand him for his poor attitude. He leaves soon after his food is delivered and Scarlett asks for it to be wrapped up for her father, Brian (Lowe), due to their money struggles.