All players and clubs without a flag are Paraguayan. Multiple transfers made in one day by a club are listed alphabetically, based on their forename.
| class="wikitable sortable" |
| Date
!Name
!Moving from
!Moving to
!Fee |
|---|
| December 2021
|Digno Gonzalez
|3 de Febrero
|Sportivo Luqueño
|N/A[{{Cite web|url=https://www.cronica.com.py/2021/12/25/digno-gonzalez-estoy-secando-la-polvora-para-lo-que-se-viene-con-luqueno/|title=Crónica / DIGNO GONZÁLEZ: "Estoy secando la pólvora para lo que se viene con Luqueño"|date=December 25, 2021}}][{{Cite web|url=https://www.abc.com.py/deportes/futbol/sportivo-luqueno/2021/12/22/digno-gonzalez-el-primer-refuerzo-del-sportivo-luqueno/|title=Digno González, el primer refuerzo del Sportivo Luqueño - Sportivo Luqueño - ABC Color|website=www.abc.com.py}}][{{Cite web|url=https://www.abc.com.py/deportes/futbol/2021/12/23/digno-gonzalez-primera-incorporacion-de-luqueno/|title=Digno González, primera incorporación de Luqueño - Fútbol - ABC Color|website=www.abc.com.py}}][{{Cite web|url=https://www.hoy.com.py/deportes/luqueno-se-rearma-con-un-goleador|title=Luqueño se rearma con un goleador|first=22 De Diciembre|last=De 2021 11:29|date=December 22, 2021}}] |
| 31 December 2021
|{{Flagicon|Argentina}} Adrian Martinez
|Cerro Porteño
|Libertad
|End of loan[{{Cite web|url=https://int.soccerway.com/teams/paraguay/cerro-porteno/1620/transfers/|title=Paraguay - Club Cerro Porteño - Results, fixtures, squad, statistics, photos, videos and news - Soccerway|website=int.soccerway.com}}] |
| 31 December 2021
|{{Flagicon|Sao_Tome_and_Principe}} Luis Leal
|Sol de America
|{{Flagicon|Bolivia}} Guabirá
|N/A[{{Cite web|url=https://int.soccerway.com/players/luis-leal-dos-anjos/142392/|title=São Tomé e Príncipe - Luís Leal - Profile with news, career statistics and history - Soccerway|website=int.soccerway.com}}] |
| 31 December 2021
|Pablo Gonzalez Ojeda
|Sportivo Trinidense
|Olimpia Asunción
|End of loan[{{Cite web|url=https://int.soccerway.com/players/pedro-gonzalez/489705/|title=Paraguay - P. González - Profile with news, career statistics and history - Soccerway|website=int.soccerway.com}}] |
| January 2022
|Fidencio Oviedo
|Independiente de Hernandarias
|Fernando de la Mora
|N/A[{{Cite web|url=https://versus.lanacion.com.py/versus/2022/01/31/fidencio-oviedo-de-la-liga-hernandariense-a-la-division-intermedia/|title=Fidencio Oviedo, de la Liga Hernandariense a la División Intermedia|date=January 31, 2022|website=Versus}}] |
| 6 January 2022
|{{Flagicon|Argentina}} Mauro Boselli
|Cerro Porteño
|{{Flagicon|Argentina}} Estudiantes LP
|Free[{{cite web|url=https://int.soccerway.com/teams/paraguay/cerro-porteno/1620/transfers/|title=Paraguay - Club Cerro Porteño - Results, fixtures, squad, statistics, photos, videos and news|website=Soccerway|access-date=2022-01-02}}] |
| 9 January 2022
|Carlos Servin
|Libertad
|Tacuary Asunción
|Free[{{Cite web|url=https://int.soccerway.com/teams/paraguay/tacuary/1622/transfers/|title=Paraguay - Tacuary FC - Results, fixtures, squad, statistics, photos, videos and news - Soccerway|website=int.soccerway.com}}] |
| 9 January 2022
|José Aquino
|3 de Febrero
|Resistencia
|Free[{{cite web|url=https://int.soccerway.com/teams/paraguay/3-de-febrero/3611/transfers/|title=Paraguay - CA 3 de Febrero - Results, fixtures, squad, statistics, photos, videos and news|website=Soccerway|access-date=2022-01-02}}] |
| 9 January 2022
|{{Flagicon|Uruguay}} Antonio Oviedo Cortizo
|Rubio Ñú
|Sportivo Ameliano
|Free[{{Cite web|url=https://int.soccerway.com/players/antonio-oviedo-cortizo/395793/|title=Uruguay - A. Oviedo - Profile with news, career statistics and history - Soccerway|website=int.soccerway.com}}] |
| 9 January 2022
|{{Flagicon|Guatemala}} José Carlos Pinto
|{{Flagicon|Guatemala}} Comunicaciones
|Tacuary Asunción
|N/A[{{Cite web|url=https://int.soccerway.com/players/jose-carlos-pinto/181308/|title=Guatemala - J. Pinto - Profile with news, career statistics and history - Soccerway|website=int.soccerway.com}}] |
| 9 January 2022
|Richard Cabrera
|Sportivo Luqueño
|Sol de América
|Free[{{cite web|url=https://int.soccerway.com/teams/paraguay/club-sportivo-luqueno/1625/transfers/|title=Paraguay - Club Sportivo Luqueño - Results, fixtures, squad, statistics, photos, videos and news|website=Soccerway|access-date=2022-01-02}}] |
| 9 January 2022
|Roque Santa Cruz
|Olimpia Asunción
|Libertad
|Free[{{cite web|url=https://int.soccerway.com/players/roque-luis-santa-cruz-cantero/410/|title=Paraguay - R. Santa Cruz - Profile with news, career statistics and history|website=Soccerway|access-date=2022-01-02}}][{{cite web|url=https://int.soccerway.com/teams/paraguay/club-libertad/1621/transfers/|title=Paraguay - Club Libertad - Results, fixtures, squad, statistics, photos, videos and news|website=Soccerway|access-date=2022-01-02}}] |
| 9 January 2022
|Santiago Salcedo
|Sportivo San Lorenzo
|General Caballero JLM
|Free[{{Cite web|url=https://int.soccerway.com/teams/paraguay/general-caballero-jlm/45947/transfers/|title=Paraguay - General Caballero JLM - Results, fixtures, squad, statistics, photos, videos and news - Soccerway|website=int.soccerway.com}}] |
| 9 January 2022
|William Mendieta
|Olimpia Asunción
|Libertad
|Free |
| 15 January 2022
|Nestor Bareiro
|Tacuary Asunción
|Deportivo Recoleta
|N/A[{{Cite web|url=https://www.abc.com.py/deportes/futbol/2022/01/15/recoleta-presenta-a-nestor-bareiro/|title=Recoleta presenta a Néstor Bareiro - Fútbol - ABC Color|website=www.abc.com.py}}] |
| 17 January 2022
|Sebastián Ferreira
|Libertad
|{{Flagicon|USA}} Houston Dynamo
|N/A[{{Cite web|url=https://int.soccerway.com/players/carlos-sebastian-ferreira/398628/|title=Paraguay - S. Ferreira - Profile with news, career statistics and history - Soccerway|website=int.soccerway.com}}] |
| 18 January 2022
|Cristian Riveros
|Nacional Asunción
|Libertad
|N/A[{{Cite web|url=https://int.soccerway.com/players/cristian-miguel-riveros-nunez/405/|title=Paraguay - C. Riveros - Profile with news, career statistics and history - Soccerway|website=int.soccerway.com}}] |
| 19 January 2022
|Edgar Zaracho
|Nacional Asunción
|Sportivo Ameliano
|Free[{{Cite web|url=https://int.soccerway.com/players/edgar-catalino-zaracho/116743/|title=Paraguay - E. Zaracho - Profile with news, career statistics and history - Soccerway|website=int.soccerway.com}}] |
| 9 February 2022
|{{Flagicon|Bolivia}} Marcelo Martins
|{{Flagicon|Brazil}} Cruzeiro
|Cerro Porteño
|N/A[{{Cite web|url=https://int.soccerway.com/players/marcelo-moreno-martins/8989/|title=Bolivia - M. Martins - Profile with news, career statistics and history - Soccerway|website=int.soccerway.com}}] |
| 11 February 2022
|{{Flagicon|Argentina}} Federico Carrizo
|Cerro Porteño
|{{Flagicon|Uruguay}} Peñarol
|Free[{{Cite web|url=https://el.soccerway.com/players/federico-carrizo/130357/|title=Argentina - F. Carrizo - Perfil con noticias, estadísticas de carrera e historia - Soccerway|website=el.soccerway.com}}] |