| class="wikitable sortable"
!
! Name
! Image
! Country
! data-sort-type="number" | Population
!Year |
| 1
| São Paulo
| 120x120px
| {{BRA}}
| 11,895,578[{{cite report |url=https://ftp.ibge.gov.br/Estimativas_de_Populacao/Estimativas_2024/estimativa_dou_2024.pdf |title=ESTIMATIVAS DA POPULAÇÃO RESIDENTE NO BRASIL E UNIDADES DA FEDERAÇÃO COM DATA DE REFERÊNCIA EM 1º DE JULHO DE 2024 |trans-title=ESTIMATES OF THE RESIDENT POPULATION IN BRAZIL AND FEDERAL UNITS WITH A REFERENCE DATE OF JULY 1, 2024 |institution=IBGE |access-date=2024-12-12 |language=pt-br}}]
| 2024 |
| 2
| Lima
| 120px
| {{PER}}
| 10,092,000{{refn|While there is no official administrative definition of the city, it is generally considered to consist of the central 30 of the 43 districts of Lima Province, corresponding to the urban area centered around the historic Cercado de Lima district.|group=lower-alpha}}[{{cite report |date=June 2023 |title=Situación de la Población Peruana - Una mirada hacia los jóvenes 2023 |url=https://www.inei.gob.pe/media/MenuRecursivo/publicaciones_digitales/Est/Lib1911/libro.pdf |institution=Inei |page=23 |docket= |access-date=2024-12-13 |language=es }}]
| 2023 |
| 3
| Bogotá
| 120px
| {{COL}}
| 7,862,277{{refn|name=Colombia|Population projections for Colombian cities are that of the cabecera municipal (municipal seat).[{{Cite web|url = https://www.dane.gov.co/files/inf_geo/4Ge_ConceptosBasicos.pdf |title = Conceptos básicos |date = 2011-05-12 |access-date = 2015-06-11 |publisher = DANE}}]|group=lower-alpha}}[{{Cite web |url=https://www.dane.gov.co/files/censo2018/proyecciones-de-poblacion/Municipal/anexo-proyecciones-poblacion-Municipal_Area_2018-2035.xlsx |title=PROYECCIONES DE POBLACIÓN MUNICIPAL POR ÁREA|date=2022-02-06 |access-date=2024-12-13 |publisher=DANE |archive-date=2022-07-20|archive-url=https://web.archive.org/web/20220720220334/https://www.dane.gov.co/files/censo2018/proyecciones-de-poblacion/Municipal/anexo-proyecciones-poblacion-Municipal_Area_2018-2035.xlsx |url-status=dead |language=es }}]
| 2024 |
| 4
| Rio de Janeiro
| 120px
| {{BRA}}
| 6,729,894
| 2024 |
| 5
| Santiago
| 120px
| {{CHI}}
| 6,254,314{{refn|The population of Santiago was calculated using the microdata base from the 2017 Chilean census. The blocks associated with the following urban areas were considered: all of Santiago Province (except Ciudad del Valle, El Cambucho, El Maitén, Lo Aguirre, and Noviciado Alto), Puente Alto, Pirque, La Obra-Las Vertientes, Las Canteras, Chamisero, Estación Colina, Valle Grande, Chicauma, San Bernardo, Padre Hurtado, and Peñaflor. Also included are unassigned blocks from the municipalities of Santiago Province, San Bernardo, Puente Alto, Padre Hurtado, and Peñaflor..|group=lower-alpha}}[{{Cite web |url=http://www.censo2017.cl/microdatos/ |title=Comunas: Actualización Población 2002-2012 y Proyecciones 2013-2020 |access-date=2024-12-13|publisher=Instituto Nacional de Estadísticas}}]
| 2017 |
| 6
| Caracas
| 120px
| {{flag|Venezuela}}
| 3,289,886{{refn|Population projection is that of the Metropolitan District of Caracas, which comprises the municipalities of Libertador, Chacao, Baruta, Sucre and El Hatillo.|group=lower-alpha}}[{{Cite web|url = http://www.ine.gob.ve/documentos/Demografia/SituacionDinamica/Proyecciones/xls/Entidades/Resumen_Municipios.xls |title = Proyección de la población al 30 de junio con base al censo 2011, según entidad federal y municipios, 2000-2050 |access-date = 2016-04-23 |publisher = Instituto Nacional de Estadística}}]
| 2015 |
| 7
| Buenos Aires
| 120px
| {{ARG}}
| 3,121,707[{{cite report |date=November 2023 |title=Censo Nacional de Población, Hogares y Viviendas 2022 – Indicadores demográficos, por sexo y edad |url=https://www.indec.gob.ar/ftp/cuadros/poblacion/censo2022_indicadores_demograficos.pdf |institution=Indec |page=22 |access-date=2024-12-13 |language=es }}]
| 2022 |
| 8
| Brasília
| 120px
| {{BRA}}
| 2,982,818
| 2024 |
| 9
| Medellín
| 120px
| {{COL}}
| 2,657,772{{refn|name=Colombia|group=lower-alpha}}
| 2024 |
| 10
| Guayaquil
| 120px
| {{ECU}}
| 2,650,288[{{cite report |date=November 2023 |title=Censo Ecuador 2022 – Tabulados |url=https://www.censoecuador.gob.ec/wp-content/uploads/2024/04/01_2022_CPV_Estructura_poblacional.xlsx |institution=Instituto Nacional de Estadística y Censos |access-date=2024-12-13 |language=es }}]
| 2022 |
| 11
| Fortaleza
| 120px
| {{BRA}}
| 2,574,412
| 2024 |
| 12
| Salvador
| 120px
| {{BRA}}
| 2,568,928
| 2024 |
| 13
| Belo Horizonte
| 120px
| {{BRA}}
| 2,416,339
| 2024 |
| 14
| Manaus
| 120px
| {{BRA}}
| 2,279,686
| 2024 |
| 15
| Cali
| 120px
| {{COL}}
| 2,270,293{{refn|name=Colombia|group=lower-alpha}}
| 2024 |
| 16
| Curitiba
| 120px
| {{BRA}}
| 1,829,225
| 2024 |
| 17
| Quito
| 120px
| {{ECU}}
| 1,763,275
| 2022 |
| 18
| Maracaibo
| 120px
| {{flag|Venezuela}}
| 1,653,211
| 2015 |
| 19
| Santa Cruz de la Sierra
| 120px
| {{BOL}}
| 1,606,671[{{cite report |date=August 2024 |title=REPORTE DE DATOS PRIMER CONTEO DE POBLACIÓN, CENSO DE POBLACIÓN Y VIVIENDA 2024 |url=https://nubecpv.ine.gob.bo/index.php/apps/onlyoffice/s/fBDwRbxQKgAxegF?fileId=548802 |institution=Ine |access-date=2024-12-13 |language=es }}]
| 2024 |
| 20
| Recife
| 120px
| {{BRA}}
| 1,587,707
| 2024 |
| 21
| Córdoba
| 120px
| {{ARG}}
| 1,505,250[{{cite report |date=November 2023 |title=Censo Nacional de Población, Hogares y Viviendas 2022 – Provincia de Córdoba |url=https://www.indec.gob.ar/ftp/cuadros/poblacion/c2022_cordoba_est_c2_6.xlsx |institution=Indec |access-date=2024-12-13 |language=es }}]
| 2022 |
| 22
| Goiânia
| 120px
| {{BRA}}
| 1,494,599
| 2024 |
| 23
| Porto Alegre
| 120px
| {{BRA}}
| 1,476,867
| 2024 |
| 24
| Belém
| 120px
| {{BRA}}
| 1,398,531
| 2024 |
| 25
| Rosario
| 120px
| {{ARG}}
| 1,348,725[{{cite report |date=November 2023 |title=Censo Nacional de Población, Hogares y Viviendas 2022 – Provincia de Santa Fe |url=https://www.indec.gob.ar/ftp/cuadros/poblacion/c2022_santafe_est_c2_21.xlsx |institution=Indec |access-date=2024-12-13 |language=es}}]
| 2022 |
| 26
| Guarulhos
| 120px
| {{BRA}}
| 1,345,364
| 2024 |
| 27
| Barranquilla
|File:Barranquillaandriomagdalena.png
| {{COL}}
| 1,341,160{{refn|name=Colombia|group=lower-alpha}}
| 2024 |
| 28
| Montevideo
| 120px
| {{URU}}
| 1,302,954[{{cite report |date=December 2024 |title=Censo 2023 – Población estimada, crecimiento intercensal y estructura por sexo y edad de Uruguay. Total país y por departamento |url=https://www5.ine.gub.uy/documents/CENSO%202023/Poblaci%C3%B3n%20estimada,%20crecimiento%20intercensal%20y%20estructura%20por%20sexo%20y%20edad.pdf |institution=Instituto Nacional de Estadística |page=4 |access-date=2024-12-13 |language=es }}]
| 2023 |
| 29
| Campinas
| 120px
| {{BRA}}
| 1,185,977
| 2024 |
| 30
| Callao
| 120x120px
| {{PER}}
| 1,171,400
| 2023 |
| 31
| Arequipa
|120x120px
| {{PER}}
| 1,157,500{{refn|INEI defines the city of Arequipa as comprising the districts of Arequipa, Alto Selva Alegre, Cayma, Cerro Colorado, Jacobo Hunter, Mariano Melgar, Miraflores, Paucarpata, Sabandía, Sachaca, Socabaya, Tiabaya, Yanahuara and José Luis Bustamante y Rivero.[{{Cite web|url =http://proyectos.inei.gob.pe/web/biblioineipub/bancopub/Est/Lib1020/cuadros/cap03.xls |title = PERÚ: LISTADO DE DISTRITOS QUE CONFORMAN LAS CIUDADES PRINCIPALES, SEGÚN DEPARTAMENTO |date = November 2010 |access-date = 2016-04-23 |website = Perú: Estimaciones y Proyecciones de Población total y edades quinquenales, según Departamento, Provincia y Distrito, 2005-2015 |publisher = INEI}}]|group=lower-alpha}}
| 2023 |
| 32
| Barquisimeto
| 120px
| | {{flag|Venezuela}}
| 1,116,182
| 2015 |
| 33
| São Luís
| 120px
| {{BRA}}
| 1,088,057
| 2024 |
| 34
| Trujillo
| 119x119px
| {{PER}}
| 1,034,300{{refn|INEI defines the city of Trujillo as comprising the districts of Trujillo, El Porvenir, Florencia de Mora, La Esperanza and Víctor Larco Herrera.
| 2023 |
| 35
| Maceió
|120x120px
| {{BRA}}
| 994,464
| 2024 |
| 36
| São Gonçalo
| 120px
| {{BRA}}
| 960,652
| 2024 |
| 37
| Campo Grande
| 120px
| {{BRA}}
| 954,537
| 2024 |
| 38
| Cartagena
| 120px
| {{COL}}
| 950,011{{refn|name=Colombia|group=lower-alpha}}
| 2024 |
| 39
| Teresina
| 120px
| {{BRA}}
| 902,644
| 2024 |
| 40
| Valencia
| 120px
| {{flag|Venezuela}}
| 901,900
| 2015 |
| 41
| El Alto
| 120px
| {{BOL}}
| 885,035
| 2024 |
| 42
| João Pessoa
| 120px
| {{BRA}}
| 888,679
| 2024 |
| 43
| Ciudad Guayana
| 120px
| {{flag|Venezuela}}
| 877,547
| 2015 |
| 44
| Duque de Caxias
| 120px
| {{BRA}}
| 866,347
| 2024 |
| 45
| Nova Iguaçu
| 120px
| {{BRA}}
| 843,046
| 2024 |
| 46
| São Bernardo do Campo
| 120px
| {{BRA}}
| 840,499
| 2024 |
| 47
| Natal
| File:Natal, capital do Rio Grande do Norte, Brasil.jpg
| {{BRA}}
| 785,368
| 2024 |
| 48
| Santo André
| 120px
| {{BRA}}
| 778,711
| 2024 |
| 49
| La Plata
| 120px
| {{ARG}}
| 768,547[{{cite report |date=November 2023 |title=Censo Nacional de Población, Hogares y Viviendas 2022 – Provincia de Buenos Aires |url=https://www.indec.gob.ar/ftp/cuadros/poblacion/c2022_bsas_est_c2_2.xlsx |institution=Indec |access-date=2024-12-13 |language=es }}]
| 2022 |
| 50
| La Paz
| 120px
| {{BOL}}
| 755,732
| 2024 |
