MED16
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.{{cite journal |vauthors=Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | journal = Nature | volume = 398 | issue = 6730 | pages = 824–8 |date=Jun 1999 | pmid = 10235266 | doi = 10.1038/19783 | bibcode =1999Natur.398..824R | s2cid = 204992765 }}{{cite journal |vauthors=Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol Cell | volume = 3 | issue = 3 | pages = 361–70 |date=Apr 1999 | pmid = 10198638 | doi =10.1016/S1097-2765(00)80463-3 | doi-access = free }}{{cite web | title = Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10025}}
Interactions
MED16 has been shown to interact with Thyroid hormone receptor alpha, Estrogen receptor alpha{{cite journal |last=Kang |first=Yun Kyoung |author2=Guermah Mohamed |author3=Yuan Chao-Xing |author4=Roeder Robert G |date=Mar 2002 |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue=5 |pages=2642–7 |location = United States| issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode =2002PNAS...99.2642K |pmc=122401 |doi-access=free }} and Cyclin-dependent kinase 8.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=10.1073/pnas.93.16.8329 | pmc=38670 |bibcode=1996PNAS...93.8329F |doi-access=free }}
- {{cite journal |vauthors=Suzuki Y, Tsunoda T, Sese J, etal |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.gr-1640r | pmc=311086 }}
- {{cite journal |vauthors=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852–8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Sato S, Tomomori-Sato C, Banks CA, etal |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 |doi-access= free }}
- {{cite journal |vauthors=Wallberg AE, Yamamura S, Malik S, etal |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137–49 |year= 2004 |pmid= 14636573 |doi=10.1016/S1097-2765(03)00391-5 |doi-access=free }}
- {{cite journal |vauthors=Tomomori-Sato C, Sato S, Parmely TJ, etal |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 |doi-access= free }}
- {{cite journal |vauthors=Sato S, Tomomori-Sato C, Parmely TJ, etal |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685–91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{refend}}
External links
- {{UCSC genome browser|MED16}}
- {{UCSC gene details|MED16}}
{{gene-19-stub}}