MED25
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.{{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}{{cite web | title = Entrez Gene: MED25 mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81857| accessdate = }}
Interactions
MED25 has been shown to interact with MED4.{{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 | doi-access = free | url = https://authors.library.caltech.edu/records/7e4h4-sxm34/files/TOMjbc04.pdf?download=1 }}
References
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Further reading
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- {{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation | journal = Nature | volume = 398 | issue = 6730 | pages = 828–32 | date = Apr 1999 | pmid = 10235267 | doi = 10.1038/19789 | bibcode = 1999Natur.398..828N | s2cid = 23646963 }}
- {{cite journal | vauthors = Wang C, McCarty IM, Balazs L, Li Y, Steiner MS | title = A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 2 | pages = 281–7 | date = Aug 2002 | pmid = 12163014 | doi = 10.1016/S0006-291X(02)00872-0 }}
- {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 49671–4 | date = Dec 2003 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 | doi-access = free | url = https://authors.library.caltech.edu/records/s8gdw-2nv54/files/SATjbc03a.pdf?download=1 }}
- {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 | doi-access = free | url = https://authors.library.caltech.edu/records/7e4h4-sxm34/files/TOMjbc04.pdf?download=1 }}
- {{cite journal | vauthors = Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, Berti L, Meisterernst M | title = A novel docking site on Mediator is critical for activation by VP16 in mammalian cells | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6494–504 | date = Dec 2003 | pmid = 14657022 | pmc = 291814 | doi = 10.1093/emboj/cdg619 }}
- {{cite journal | vauthors = Yang F, DeBeaumont R, Zhou S, Näär AM | title = The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2339–44 | date = Feb 2004 | pmid = 14983011 | pmc = 356952 | doi = 10.1073/pnas.0308676100 | bibcode = 2004PNAS..101.2339Y | doi-access = free }}
- {{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Molecular Cell | volume = 14 | issue = 5 | pages = 685–91 | date = Jun 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 | doi-access = free }}
- {{cite journal | vauthors = Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG | title = MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription | journal = Molecular Cell | volume = 19 | issue = 1 | pages = 89–100 | date = Jul 2005 | pmid = 15989967 | doi = 10.1016/j.molcel.2005.05.015 | doi-access = free }}
- {{cite journal | vauthors = Lee HK, Park UH, Kim EJ, Um SJ | title = MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation | journal = The EMBO Journal | volume = 26 | issue = 15 | pages = 3545–57 | date = Aug 2007 | pmid = 17641689 | pmc = 1949011 | doi = 10.1038/sj.emboj.7601797 }}
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External links
- [https://www.ncbi.nlm.nih.gov/books/NBK1285/ GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2]
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