MED4

The protein encoded by this gene is a component of the vitamin D receptor-interacting protein (DRIP) complex which functions as a nuclear receptor coactivator. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.

MED4 has been shown to interact with MED25.{{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = J. Biol. Chem. | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 | doi-access = free | url = https://authors.library.caltech.edu/records/7e4h4-sxm34/files/TOMjbc04.pdf?download=1 }}

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• {{cite journal | vauthors = Conaway JW, Florens L, Sato S, Tomomori-Sato C, Parmely TJ, Yao T, Swanson SK, Banks CA, Washburn MP, Conaway RC | title = The mammalian Mediator complex. | journal = FEBS Lett. | volume = 579 | issue = 4 | pages = 904–8 | year = 2005 | pmid = 15680972 | doi = 10.1016/j.febslet.2004.11.031 | s2cid = 45924145 | doi-access = }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. | journal = Mol. Cell | volume = 3 | issue = 3 | pages = 361–70 | year = 1999 | pmid = 10198638 | doi = 10.1016/S1097-2765(00)80463-3 | doi-access = free }}
• {{cite journal | vauthors = Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. | journal = Nature | volume = 398 | issue = 6730 | pages = 824–8 | year = 1999 | pmid = 10235266 | doi = 10.1038/19783 | bibcode = 1999Natur.398..824R | s2cid = 204992765 }}
• {{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation. | journal = Nature | volume = 398 | issue = 6730 | pages = 828–32 | year = 1999 | pmid = 10235267 | doi = 10.1038/19789 | bibcode = 1999Natur.398..828N | s2cid = 23646963 }}
• {{cite journal | vauthors = Malik S, Gu W, Wu W, Qin J, Roeder RG | title = The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. | journal = Mol. Cell | volume = 5 | issue = 4 | pages = 753–60 | year = 2000 | pmid = 10882111 | doi = 10.1016/S1097-2765(00)80254-3 | doi-access = free }}
• {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. | journal = Genome Res. | volume = 10 | issue = 10 | pages = 1546–60 | year = 2001 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}

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{{Transcription coregulators}}

{{gene-13-stub}}