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MPGES-1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox gene}}

Microsomal prostaglandin E synthase-1 (mPGES-1){{cite journal |vauthors=Jakobsson PJ, Thorén S, Morgenstern R, et al. | title = Identification of human prostaglandin E synthase: a microsomal glutathione-dependent, inducible enzyme, constituting a potential novel drug target. | journal = Proc Natl Acad Sci USA | volume = 96 | issue = 13| pages = 7220–7225 |date= 1989 | pmid = 10377395 | pmc = 22058| doi = 10.1073/pnas.96.13.7220 | bibcode = 1999PNAS...96.7220J | doi-access = free }}{{cite journal |author1=Hui-Hua Chang |author2=Emmanuelle J Meuillet | title = Identification and development of mPGES-1 inhibitors: where we are at? | journal = Future Med Chem | volume = 3 | issue = 15 | pages = 1909–1934 |date= 2011 | pmid = 22023034| pmc = 3232027 | doi = 10.4155/fmc.11.136 }} or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.{{cite journal |vauthors=Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B | title = A model for p53-induced apoptosis | journal = Nature | volume = 389 | issue = 6648 | pages = 300–5 |date=Sep 1997 | pmid = 9305847 | doi = 10.1038/38525 | bibcode = 1997Natur.389..300P | s2cid = 4429638 }}{{cite journal |vauthors=Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B | title = Common structural features of MAPEG -- a widespread superfamily of membrane-associated proteins with highly divergent functions in eicosanoid and glutathione metabolism | journal = Protein Sci | volume = 8 | issue = 3 | pages = 689–92 |date=May 1999 | pmid = 10091672 | pmc = 2144274 | doi = 10.1110/ps.8.3.689 }}{{cite web | title = Entrez Gene: PTGES prostaglandin E synthase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9536}}

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.

Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

It is inhibited by crisdesalazine (AAD-2004; GedaCure).{{cite journal | vauthors = Dunkel P, Chai CL, Sperlágh B, Huleatt PB, Mátyus P | title = Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis | journal = Expert Opin Investig Drugs | volume = 21 | issue = 9 | pages = 1267–308 | date = September 2012 | pmid = 22741814 | doi = 10.1517/13543784.2012.703178 | url = }}

See also

References

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Further reading

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  • {{cite journal | author=Bastien L |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873–7 |year= 1994 |pmid= 8163486 |name-list-style=vanc| author2=Sawyer N | author3=Grygorczyk R | display-authors=3 | last4=Metters | first4=KM | last5=Adam | first5=M |doi=10.1016/S0021-9258(17)32654-6 |doi-access=free }}
  • {{cite journal |vauthors=Wu T, Wu H, Wang J, Wang J |title=Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain. |journal=J Neuroinflammation |volume=8 |pages= 22 |year= 2011 |pmid= 21385433 |doi=10.1186/1742-2094-8-22 | pmc=3062590 |doi-access=free }}
  • {{cite journal | author=Funk CD |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767–72 |year= 1994 |pmid= 8253813 |name-list-style=vanc| author2=Furci L | author3=FitzGerald GA | display-authors=3 | last4=Grygorczyk | first4=R | last5=Rochette | first5=C | last6=Bayne | first6=MA | last7=Abramovitz | first7=M | last8=Adam | first8=M | last9=Metters | first9=KM |doi=10.1016/S0021-9258(19)74379-8 | doi-access=free }}
  • {{cite journal | author=Giacomini E |title=Increased PGE2 production mediates the in vitro inhibitory effect of the human immunodeficiency virus P24 immunosuppressive heptapeptide Ch7 |journal=Scand. J. Immunol. |volume=48 |issue= 3 |pages= 248–53 |year= 1998 |pmid= 9743208 |doi=10.1046/j.1365-3083.1998.00389.x |name-list-style=vanc| author2=Giordani L | author3=di Modugno F | display-authors=3 | last4=Chersi | last5=Luzzati | first4=A | first5=AL |s2cid=20332912 |doi-access=}}
  • {{cite journal |vauthors=Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B |title=Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 13 |pages= 7220–5 |year= 1999 |pmid= 10377395 |doi=10.1073/pnas.96.13.7220 | pmc=22058 |bibcode=1999PNAS...96.7220J |doi-access=free }}
  • {{cite journal | author=Forsberg L |title=Human glutathione dependent prostaglandin E synthase: gene structure and regulation |journal=FEBS Lett. |volume=471 |issue= 1 |pages= 78–82 |year= 2000 |pmid= 10760517 |doi=10.1016/S0014-5793(00)01367-3 |name-list-style=vanc| author2=Leeb L | author3=Thorén S | display-authors=3 | last4=Morgenstern | first4=R | last5=Jakobsson | first5=P |s2cid=10901322 |doi-access=}}
  • {{cite journal |vauthors=Han R, Smith TJ |title=Cytoplasmic prostaglandin E2 synthase is dominantly expressed in cultured KAT-50 thyrocytes, cells that express constitutive prostaglandin-endoperoxide H synthase-2. Basis for low protaglandin E2 production |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36897–903 |year= 2002 |pmid= 12145315 |doi= 10.1074/jbc.M206949200 |doi-access= free }}
  • {{cite journal | author=Giannoulias D |title=Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5274–82 |year= 2002 |pmid= 12414902 |doi=10.1210/jc.2002-020521 |name-list-style=vanc| author2=Alfaidy N | author3=Holloway AC | display-authors=3 | last4=Gibb | first4=W | last5=Sun | first5=M | last6=Lye | first6=SJ | last7=Challis | first7=JR | doi-access=free }}
  • {{cite journal | author=Ouellet M |title=Purification and characterization of recombinant microsomal prostaglandin E synthase-1 |journal=Protein Expr. Purif. |volume=26 |issue= 3 |pages= 489–95 |year= 2003 |pmid= 12460774 |doi=10.1016/S1046-5928(02)00566-1 |name-list-style=vanc| author2=Falgueyret JP | author3=Ear PH | display-authors=3 | last4=Pen | first4=A | last5=Mancini | first5=JA | last6=Riendeau | first6=D | last7=Percival | first7=MD }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Uracz W, Uracz D, Olszanecki R, Gryglewski RJ |title=Interleukin 1beta induces functional prostaglandin E synthase in cultured human umbilical vein endothelial cells |journal=J. Physiol. Pharmacol. |volume=53 |issue= 4 Pt 1 |pages= 643–54 |year= 2003 |pmid= 12512699 }}
  • {{cite journal |vauthors=Meadows JW, Eis AL, Brockman DE, Myatt L |title=Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 1 |pages= 433–9 |year= 2003 |pmid= 12519887 |doi=10.1210/jc.2002-021061 |doi-access=free }}
  • {{cite journal | author=Kamei D |title=Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19396–405 |year= 2003 |pmid= 12626523 |doi= 10.1074/jbc.M213290200 |name-list-style=vanc| author2=Murakami M | author3=Nakatani Y | display-authors=3 | last4=Ishikawa | first4=Y | last5=Ishii | first5=T | last6=Kudo | first6=I | doi-access=free}}
  • {{cite book |vauthors=Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B |chapter=Characterization of Microsomal, Glutathione Dependent Prostaglandin e Synthase |title=Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5 |volume=507 |pages= 287–91 |year= 2003 |pmid= 12664599 |doi=10.1007/978-1-4615-0193-0_44 | series=Advances in Experimental Medicine and Biology | isbn=978-0-306-47283-1 }}
  • {{cite journal | author=Thorén S |title=Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22199–209 |year= 2003 |pmid= 12672824 |doi= 10.1074/jbc.M303227200 |name-list-style=vanc| author2=Weinander R | author3=Saha S | display-authors=3 | last4=Jegerschöld | first4=C | last5=Pettersson | first5=PL | last6=Samuelsson | first6=B | last7=Hebert | first7=H | last8=Hamberg | first8=M | last9=Morgenstern | first9=R | doi-access=free }}
  • {{cite journal |vauthors=Alfaidy N, Sun M, Challis JR, Gibb W |title=Expression of membrane prostaglandin E synthase in human placenta and fetal membranes and effect of labor |journal=Endocrine |volume=20 |issue= 3 |pages= 219–25 |year= 2003 |pmid= 12721500 |doi=10.1385/ENDO:20:3:219 |s2cid=9590845 }}
  • {{cite journal | author=Ekström L |title=Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3 |journal=Biochim. Biophys. Acta |volume=1627 |issue= 2–3 |pages= 79–84 |year= 2003 |pmid= 12818425 |doi= 10.1016/S0167-4781(03)00077-0|name-list-style=vanc| author2=Lyrenäs L | author3=Jakobsson PJ | display-authors=3 | last4=Morgenstern | first4=R | last5=Kelner | first5=MJ }}
  • {{cite journal | author=Murakami M |title=Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2 |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37937–47 |year= 2003 |pmid= 12835322 |doi= 10.1074/jbc.M305108200 |name-list-style=vanc| author2=Nakashima K | author3=Kamei D | display-authors=3 | last4=Masuda | first4=S | last5=Ishikawa | first5=Y | last6=Ishii | first6=T | last7=Ohmiya | first7=Y | last8=Watanabe | first8=K | last9=Kudo | first9=I | doi-access=free }}
  • {{cite journal | author=Trebino CE |title=Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 9044–9 |year= 2003 |pmid= 12835414 |doi= 10.1073/pnas.1332766100 | pmc=166435 |name-list-style=vanc| author2=Stock JL | author3=Gibbons CP | display-authors=3 | last4=Naiman | first4=BM | last5=Wachtmann | first5=TS | last6=Umland | first6=JP | last7=Pandher | first7=K | last8=Lapointe | first8=JM | last9=Saha | first9=S |bibcode=2003PNAS..100.9044T |doi-access=free }}

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