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MRGPRX2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.{{cite journal | vauthors = Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ | title = A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons | journal = Cell | volume = 106 | issue = 5 | pages = 619–632 | date = September 2001 | pmid = 11551509 | doi = 10.1016/S0092-8674(01)00483-4 | doi-access = free }}{{cite web | title = Entrez Gene: MRGPRX2 MAS-related GPR, member X2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117194}} It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.{{Cite book |url=https://www.worldcat.org/title/on1295106160 | vauthors = Akin C, Elhosni M, Khokar DS | chapter = Mast Cells and Mast Cell disorders | page = 563 | veditors = Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck J |title=Clinical immunology: principles and practice |date=2023 |publisher=Elsevier |isbn=978-0-7020-8165-1 }}

Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity-like symptoms, also known as pseudoallergic reactions, although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome{{Cite web |title=Vancomycin Infusion Reaction - StatPearls - NCBI Bookshelf |url=https://www.ncbi.nlm.nih.gov/books/NBK482506/ |author1=Thomas J. Martel | author2=Radia T. Jamil |author3=Muriam Afzal}}), icatibant, leuprolide, and morphine.

See also

References

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Further reading

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  • {{cite journal | vauthors = Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence | journal = FEBS Letters | volume = 520 | issue = 1–3 | pages = 97–101 | date = June 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 | s2cid = 7116392 | doi-access = | bibcode = 2002FEBSL.520...97T }}
  • {{cite journal | vauthors = Robas N, Mead E, Fidock M | title = MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion | journal = The Journal of Biological Chemistry | volume = 278 | issue = 45 | pages = 44400–44404 | date = November 2003 | pmid = 12915402 | doi = 10.1074/jbc.M302456200 | doi-access = free }}
  • {{cite journal | vauthors = Yang S, Liu Y, Lin AA, Cavalli-Sforza LL, Zhao Z, Su B | title = Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception | journal = Gene | volume = 352 | pages = 30–35 | date = June 2005 | pmid = 15862286 | doi = 10.1016/j.gene.2005.03.001 }}

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{{G protein-coupled receptors}}

Category:G protein-coupled receptors

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