Mantle zone
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| Name = Mantle zone
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| Image = Dark, light, mantle and marginal zones of a secondary follicle.png
| Caption = Histology of a normal secondary lymphoid follicle, with yellow arrows pointing at the mantle zone.
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The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.{{cite web |url=http://teaching.path.cam.ac.uk/partIB_pract/P05/ |title=University of Cambridge: Department of Pathology |access-date=2008-07-29 |url-status=dead |archive-url=https://web.archive.org/web/20080603110413/http://teaching.path.cam.ac.uk/partIB_pract/P05/ |archive-date=2008-06-03 }}
It is also known as the "corona".{{cite web |url=http://www3.umdnj.edu/histsweb/lab12/lab12nodes.html |title=Lymph Nodes |access-date=2008-07-29 |url-status=dead |archive-url=https://web.archive.org/web/20080317074847/http://www3.umdnj.edu/histsweb/lab12/lab12nodes.html |archive-date=2008-03-17 }}
It contains transient lymphocytes.{{cite web |url=http://www.dartmouth.edu/~nlevy/levylecture.html |title=Pathology of lymph nodes – Dr. Levy |website=www.dartmouth.edu |url-status=dead |archive-url=https://web.archive.org/web/19991105133631/http://www.dartmouth.edu/~nlevy/levylecture.html |archive-date=1999-11-05}}
It is the location of the lymphoma in mantle cell lymphoma.
Pathology
Image:Castleman disease - intermed mag.jpg of Castleman disease showing the characteristic expansion of the mantle zone. H&E stain]]
Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.
References
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External links
- https://web.archive.org/web/20080813003821/http://erl.pathology.iupui.edu/HISTO/LABE109.HTM
- {{BUHistology|07102loa}} — "Lymphoid Tissues and Organs: lymph node, cortex and medulla"
{{Lymphoid system}}