Metergoline
{{Short description|Chemical compound}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 462249407
| IUPAC_name = benzyl N-
| image = Metergoline.svg
| width = 225px
| tradename = Contralac, Liserdol
| Drugs.com =
| MedlinePlus =
| pregnancy_category=
| legal_status = Rx-only
| routes_of_administration = Oral
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 17692-51-2
| ATC_prefix = G02
| ATC_suffix = CB05
| PubChem = 28693
| IUPHAR_ligand = 133
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 26687
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 1501393LY5
| ChEBI = 64216
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 19215
| synonyms = Methergoline; FI-6337; [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
| C=25 | H=29 | N=3 | O=2
| SMILES = O=C(OCc1ccccc1)NC[C@@H]3C[C@@H]4c5cccc2c5c(cn2C)C[C@H]4N(C3)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = WZHJKEUHNJHDLS-QTGUNEKASA-N
}}
Metergoline ({{Abbrlink|INN|International Nonproprietary Name|INN}}, {{Abbrlink|BAN|British Approved Name}}), also known as methergoline and sold under the brand names Contralac (veterinary) and Liserdol (clinical), is a monoaminergic medication of the ergoline group which is used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) and to suppress lactation.{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA661|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=661–}}{{cite book| vauthors = Plumb DC | chapter = Metergoline |title=Plumb's Veterinary Drug Handbook: Pocket| chapter-url = https://books.google.com/books?id=wshQDwAAQBAJ&pg=PA1057 |date=21 February 2018|publisher=John Wiley & Sons|isbn=978-1-119-34649-4|pages=1057–}}{{cite book| vauthors = Johson CA | chapter = False Pregnancy, Disorders of Pregnancy and Parturition, and Mismating | veditors = Nelson RW, Couto CG |title=Small Animal Internal Medicine - E-Book| chapter-url=https://books.google.com/books?id=s-TXrwyo-_YC&pg=PA927|date=2 December 2008|publisher=Elsevier Health Sciences|isbn=978-0-323-06512-2|pages=927–}}
Pharmacology
=Pharmacodynamics=
Metergoline is a ligand of various serotonin and dopamine receptors.{{cite journal | vauthors = Hamon M, Mallat M, Herbet A, Nelson DL, Audinot M, Pichat L, Glowinski J | title = [3H]Metergoline: a new ligand of serotonin receptors in the rat brain | journal = Journal of Neurochemistry | volume = 36 | issue = 2 | pages = 613–626 | date = February 1981 | pmid = 7463079 | doi = 10.1111/j.1471-4159.1981.tb01634.x | s2cid = 20259621 }}{{cite journal | vauthors = Miller KJ, King A, Demchyshyn L, Niznik H, Teitler M | title = Agonist activity of sumatriptan and metergoline at the human 5-HT1D beta receptor: further evidence for a role of the 5-HT1D receptor in the action of sumatriptan | journal = European Journal of Pharmacology | volume = 227 | issue = 1 | pages = 99–102 | date = September 1992 | pmid = 1330643 | doi = 10.1016/0922-4106(92)90149-P }}
References
{{Reflist}}
External links
- {{MeshName|Metergoline}}
{{Prolactin inhibitors and anti-inflammatory products for vaginal administration}}
{{Other gynecologicals}}
{{Navboxes
| title = Pharmacodynamics
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{{Dopamine receptor modulators}}
{{Prolactin receptor modulators}}
{{Serotonin receptor modulators}}
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{{Ergolines}}