Monocarboxylate transporter 3
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.{{cite journal | vauthors = Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS | title = Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle | journal = Cell | volume = 76 | issue = 5 | pages = 865–73 | date = Mar 1994 | pmid = 8124722 | doi = 10.1016/0092-8674(94)90361-1 | s2cid = 22137883 }} MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.
Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.
See also
References
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Further reading
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- {{cite journal | vauthors = Yoon H, Donoso LA, Philp NJ | title = Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2 | journal = Genomics | volume = 60 | issue = 3 | pages = 366–70 | year = 1999 | pmid = 10493836 | doi = 10.1006/geno.1999.5926 }}
- {{cite journal | vauthors = Philp NJ, Wang D, Yoon H, Hjelmeland LM | title = Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells | journal = Invest. Ophthalmol. Vis. Sci. | volume = 44 | issue = 4 | pages = 1716–21 | year = 2003 | pmid = 12657613 | doi = 10.1167/iovs.02-0287| doi-access = }}
- {{cite journal | vauthors = Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP | title = Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70) | journal = J. Biol. Chem. | volume = 280 | issue = 29 | pages = 27213–21 | year = 2005 | pmid = 15917240 | doi = 10.1074/jbc.M411950200 | doi-access = free }}
- {{cite journal | vauthors = Cori CF | title = The glucose-lactic acid cycle and gluconeogenesis | journal = Curr. Top. Cell. Regul. | series = Current Topics in Cellular Regulation | volume = 18 | pages = 377–87 | year = 1981 | doi = 10.1016/B978-0-12-152818-8.50028-1 | pmid = 7273846 | isbn = 9780121528188 }}
- {{cite journal | vauthors = Halestrap AP, Meredith D | title = The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond | journal = Pflügers Arch. | volume = 447 | issue = 5 | pages = 619–28 | year = 2004 | pmid = 12739169 | doi = 10.1007/s00424-003-1067-2 | s2cid = 15498611 }}
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{{Membrane transport proteins|bg|bg1}}
Category:Solute carrier family
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