NEK9
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{{Short description|Protein-coding gene in humans}}
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Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene.{{cite journal | vauthors = Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD | title = Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 16229–40 | date = May 2002 | pmid = 11864968 | doi = 10.1074/jbc.M108662200 | doi-access = free }}{{cite web | title = Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91754}}
Interactions
NEK9 has been shown to interact with:
- NEK6,{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}{{cite journal | vauthors = Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J | title = A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases | journal = The Journal of Biological Chemistry | volume = 278 | issue = 37 | pages = 34897–909 | date = Sep 2003 | pmid = 12840024 | doi = 10.1074/jbc.M303663200 | doi-access = free }}{{cite journal | vauthors = Roig J, Mikhailov A, Belham C, Avruch J | title = Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression | journal = Genes & Development | volume = 16 | issue = 13 | pages = 1640–58 | date = Jul 2002 | pmid = 12101123 | pmc = 186374 | doi = 10.1101/gad.972202 }}
- RAN, and
- SSRP1.{{cite journal | vauthors = Tan BC, Lee SC | title = Nek9, a novel FACT-associated protein, modulates interphase progression | journal = The Journal of Biological Chemistry | volume = 279 | issue = 10 | pages = 9321–30 | date = Mar 2004 | pmid = 14660563 | doi = 10.1074/jbc.M311477200 | doi-access = free}}
References
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Further reading
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- {{cite journal | vauthors = Pelka P, Scimè A, Mandalfino C, Joch M, Abdulla P, Whyte P | title = Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase | journal = Journal of Cellular Physiology | volume = 212 | issue = 1 | pages = 13–25 | date = Jul 2007 | pmid = 17443675 | doi = 10.1002/jcp.20983 | s2cid = 41137896 }}
- {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
- {{cite journal | vauthors = Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H | title = Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 6 | issue = 3 | pages = 537–47 | date = Mar 2007 | pmid = 17192257 | doi = 10.1074/mcp.T600062-MCP200 | url = https://hzi.openrepository.com/bitstream/10033/19756/1/Wissing%20et%20al_final.pdf | doi-access = free }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | doi-access = free }}
- {{cite journal | vauthors = Bowers AJ, Boylan JF | title = Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors | journal = Gene | volume = 328 | pages = 135–42 | date = Mar 2004 | pmid = 15019993 | doi = 10.1016/j.gene.2003.12.002 }}
- {{cite journal | vauthors = Tan BC, Lee SC | title = Nek9, a novel FACT-associated protein, modulates interphase progression | journal = The Journal of Biological Chemistry | volume = 279 | issue = 10 | pages = 9321–30 | date = Mar 2004 | pmid = 14660563 | doi = 10.1074/jbc.M311477200 | doi-access = free}}
- {{cite journal | vauthors = Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J | title = A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases | journal = The Journal of Biological Chemistry | volume = 278 | issue = 37 | pages = 34897–909 | date = Sep 2003 | pmid = 12840024 | doi = 10.1074/jbc.M303663200 | doi-access = free }}
- {{cite journal | vauthors = Roig J, Mikhailov A, Belham C, Avruch J | title = Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression | journal = Genes & Development | volume = 16 | issue = 13 | pages = 1640–58 | date = Jul 2002 | pmid = 12101123 | pmc = 186374 | doi = 10.1101/gad.972202 }}
- {{cite journal | vauthors = Ohara O, Nagase T, Mitsui G, Kohga H, Kikuno R, Hiraoka S, Takahashi Y, Kitajima S, Saga Y, Koseki H | title = Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method | journal = DNA Research | volume = 9 | issue = 2 | pages = 47–57 | date = Apr 2002 | pmid = 12056414 | doi = 10.1093/dnares/9.2.47 | doi-access = free }}
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