Structure specific recognition protein 1

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.

Structure specific recognition protein 1 has been shown to interact with NEK9.{{cite journal | vauthors = Tan BC, Lee SC | title = Nek9, a novel FACT-associated protein, modulates interphase progression | journal = J. Biol. Chem. | volume = 279 | issue = 10 | pages = 9321–30 | date = Mar 2004 | pmid = 14660563 | doi = 10.1074/jbc.M311477200 | doi-access = free }}

SSRP1 further interacts with transcriptional activator p63.{{cite journal | vauthors = Zeng SX, Dai MS, Keller DM, Lu H | title = SSRP1 functions as a co-activator of the transcriptional activator p63 | journal = EMBO J. | volume = 21 | issue = 20 | pages = 5487–97 | date = 15 Oct 2002 | pmid = 12374749 | pmc = 129072 | doi = 10.1093/emboj/cdf540 }} SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.

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• {{cite journal | vauthors = Bruhn SL, Pil PM, Essigmann JM, Housman DE, Lippard SJ | title = Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 6 | pages = 2307–11 | year = 1992 | pmid = 1372440 | pmc = 48646 | doi = 10.1073/pnas.89.6.2307 | bibcode = 1992PNAS...89.2307B | doi-access = free }}
• {{cite journal | vauthors = Toney JH, Donahue BA, Kellett PJ, Bruhn SL, Essigmann JM, Lippard SJ | title = Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II) | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | issue = 21 | pages = 8328–32 | year = 1989 | pmid = 2530581 | pmc = 298274 | doi = 10.1073/pnas.86.21.8328 | bibcode = 1989PNAS...86.8328T | doi-access = free }}
• {{cite journal | vauthors = Nagulapalli S, Pongubala JM, Atchison ML | title = Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). | journal = J. Immunol. | volume = 155 | issue = 9 | pages = 4330–8 | year = 1995 | doi = 10.4049/jimmunol.155.9.4330 | pmid = 7594592 | doi-access = free }}
• {{cite journal | vauthors = Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D | title = FACT, a factor that facilitates transcript elongation through nucleosomes. | journal = Cell | volume = 92 | issue = 1 | pages = 105–16 | year = 1998 | pmid = 9489704 | doi = 10.1016/S0092-8674(00)80903-4 | s2cid = 11248520 | doi-access = free }}
• {{cite journal | vauthors = Dyer MA, Hayes PJ, Baron MH | title = The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. | journal = Mol. Cell. Biol. | volume = 18 | issue = 5 | pages = 2617–28 | year = 1998 | pmid = 9566881 | pmc = 110641 | doi = 10.1128/MCB.18.5.2617}}
• {{cite journal | vauthors = LeRoy G, Orphanides G, Lane WS, Reinberg D | title = Requirement of RSF and FACT for transcription of chromatin templates in vitro. | journal = Science | volume = 282 | issue = 5395 | pages = 1900–4 | year = 1998 | pmid = 9836642 | doi = 10.1126/science.282.5395.1900 }}
• {{cite journal | vauthors = Kelley DE, Stokes DG, Perry RP | title = CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. | journal = Chromosoma | volume = 108 | issue = 1 | pages = 10–25 | year = 1999 | pmid = 10199952 | doi = 10.1007/s004120050347 | s2cid = 12945778 }}
• {{cite journal | vauthors = Spencer JA, Baron MH, Olson EN | title = Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. | journal = J. Biol. Chem. | volume = 274 | issue = 22 | pages = 15686–93 | year = 1999 | pmid = 10336466 | doi = 10.1074/jbc.274.22.15686 | doi-access = free }}
• {{cite journal | vauthors = Orphanides G, Wu WH, Lane WS, Hampsey M, Reinberg D | title = The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. | journal = Nature | volume = 400 | issue = 6741 | pages = 284–8 | year = 1999 | pmid = 10421373 | doi = 10.1038/22350 | bibcode = 1999Natur.400..284O | s2cid = 4300397 }}
• {{cite journal | vauthors = Wada T, Orphanides G, Hasegawa J, Kim DK, Shima D, Yamaguchi Y, Fukuda A, Hisatake K, Oh S, Reinberg D, Handa H | title = FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. | journal = Mol. Cell | volume = 5 | issue = 6 | pages = 1067–72 | year = 2000 | pmid = 10912001 | doi = 10.1016/S1097-2765(00)80272-5 | doi-access = free }}
• {{cite journal | vauthors = Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H | title = A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. | journal = Mol. Cell | volume = 7 | issue = 2 | pages = 283–92 | year = 2001 | pmid = 11239457 | doi = 10.1016/S1097-2765(01)00176-9 | doi-access = free }}
• {{cite journal | vauthors = Yarnell AT, Oh S, Reinberg D, Lippard SJ | title = Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 25736–41 | year = 2001 | pmid = 11344167 | doi = 10.1074/jbc.M101208200 | doi-access = free }}
• {{cite journal | vauthors = Santoro P, De Andrea M, Migliaretti G, Trapani C, Landolfo S, Gariglio M | title = High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases. | journal = J. Rheumatol. | volume = 29 | issue = 1 | pages = 90–3 | year = 2002 | pmid = 11824977 }}
• {{cite journal | vauthors = Roig J, Mikhailov A, Belham C, Avruch J | title = Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. | journal = Genes Dev. | volume = 16 | issue = 13 | pages = 1640–58 | year = 2002 | pmid = 12101123 | pmc = 186374 | doi = 10.1101/gad.972202 }}
• {{cite journal | vauthors = Zeng SX, Dai MS, Keller DM, Lu H | title = SSRP1 functions as a co-activator of the transcriptional activator p63. | journal = EMBO J. | volume = 21 | issue = 20 | pages = 5487–97 | year = 2002 | pmid = 12374749 | pmc = 129072 | doi = 10.1093/emboj/cdf540 }}
• {{cite journal | vauthors = Keller DM, Lu H | title = p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 50206–13 | year = 2003 | pmid = 12393879 | doi = 10.1074/jbc.M209820200 | doi-access = free }}
• {{cite journal | vauthors = Belotserkovskaya R, Oh S, Bondarenko VA, Orphanides G, Studitsky VM, Reinberg D | title = FACT facilitates transcription-dependent nucleosome alteration. | journal = Science | volume = 301 | issue = 5636 | pages = 1090–3 | year = 2003 | pmid = 12934006 | doi = 10.1126/science.1085703 | bibcode = 2003Sci...301.1090B | s2cid = 26667338 }}
• {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of alternative splicing by SRrp86 and its interacting proteins. | journal = Mol. Cell. Biol. | volume = 23 | issue = 21 | pages = 7437–47 | year = 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }}
• {{cite journal | vauthors = Tan BC, Lee SC | title = Nek9, a novel FACT-associated protein, modulates interphase progression. | journal = J. Biol. Chem. | volume = 279 | issue = 10 | pages = 9321–30 | year = 2004 | pmid = 14660563 | doi = 10.1074/jbc.M311477200 | doi-access = free }}

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• {{MeshName|SSRP1+protein,+human}}

{{NLM content}}

{{Transcription factors|g4}}

Category:Transcription factors

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