NEUROD2

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.

NEUROD2 has been shown to interact with Protein kinase N1.{{cite journal | vauthors = Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y | title = Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2 | journal = Brain Research. Molecular Brain Research | volume = 74 | issue = 1–2 | pages = 126–34 | date = Dec 1999 | pmid = 10640683 | doi = 10.1016/S0169-328X(99)00273-9 }}

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• {{cite journal | vauthors = McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ | title = NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family | journal = Molecular and Cellular Biology | volume = 16 | issue = 10 | pages = 5792–800 | date = Oct 1996 | pmid = 8816493 | pmc = 231580 | doi = 10.1128/mcb.16.10.5792}}
• {{cite journal | vauthors = Kume H, Maruyama K, Shinozaki K, Kuzume H, Obata K | title = Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein | journal = Brain Research. Molecular Brain Research | volume = 60 | issue = 1 | pages = 107–14 | date = Sep 1998 | pmid = 9748526 | doi = 10.1016/S0169-328X(98)00176-4 }}
• {{cite journal | vauthors = Kitamura T, Miyachi T, Nakamura S, Kawakami H | title = Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1 | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1445 | issue = 1 | pages = 142–7 | date = Apr 1999 | pmid = 10209266 | doi = 10.1016/s0167-4781(99)00038-x }}
• {{cite journal | vauthors = Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y | title = Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2 | journal = Brain Research. Molecular Brain Research | volume = 74 | issue = 1–2 | pages = 126–34 | date = Dec 1999 | pmid = 10640683 | doi = 10.1016/S0169-328X(99)00273-9 }}
• {{cite journal | vauthors = Cousin P, Billotte J, Chaubert P, Shaw P | title = Physical map of 17p13 and the genes adjacent to p53 | journal = Genomics | volume = 63 | issue = 1 | pages = 60–8 | date = Jan 2000 | pmid = 10662545 | doi = 10.1006/geno.1999.6062 }}
• {{cite journal | vauthors = Franklin A, Kao A, Tapscott S, Unis A | title = NeuroD homologue expression during cortical development in the human brain | journal = Journal of Child Neurology | volume = 16 | issue = 11 | pages = 849–53 | date = Nov 2001 | pmid = 11732772 | doi = 10.1177/08830738010160111201 | s2cid = 20069074 }}
• {{cite journal | vauthors = Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB | title = The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion | journal = Mechanisms of Development | volume = 113 | issue = 1 | pages = 85–90 | date = Apr 2002 | pmid = 11900979 | doi = 10.1016/S0925-4773(01)00665-7 | s2cid = 11607202 | doi-access = }}
• {{cite journal | vauthors = Westerman BA, Chhatta A, Poutsma A, van Vegchel T, Oudejans CB | title = NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1676 | issue = 1 | pages = 96–103 | date = Jan 2004 | pmid = 14732494 | doi = 10.1016/j.bbaexp.2003.10.002 | doi-access = }}
• {{cite journal | vauthors = Zill P, Büttner A, Eisenmenger W, Bondy B | title = A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior | journal = Molecular Psychiatry | volume = 11 | issue = 6 | pages = 525–7 | date = Jun 2006 | pmid = 16607387 | doi = 10.1038/sj.mp.4001825 | doi-access = | s2cid = 7713810 }}

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• {{MeshName|NEUROD2+protein,+human}}

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{{Transcription factors|g1}}

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Category:Transcription factors

Category:Human proteins

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